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Effects of static magnetic field and cadmium on oxidative stress and DNA damage in rat cortex brain and hippocampus.

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Amara S, Douki T, Garrel C, Favier A, Ben Rhouma K, Sakly M, Abdelmelek H. · 2011

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In rats, combining a static magnetic field with cadmium increased oxidative damage in the brain beyond what cadmium alone caused.

Plain English Summary

Summary written for general audiences

Researchers studied the effects of co-exposure to a static magnetic field (SMF) and cadmium on antioxidant enzyme activity and DNA integrity in rat brain. Cadmium exposure alone reduced antioxidant enzyme activity, including GPx, CAT, and SOD, in the frontal cortex and hippocampus, and increased markers of oxidative damage. When SMF (128 mT, 1 hour/day for 30 consecutive days) was combined with cadmium, SOD activity and glutathione levels in the frontal cortex fell further compared with the cadmium-only group, and MDA concentration also increased further. SMF exposure did not alter DNA oxidation levels in cadmium-exposed rats.

Why This Matters

The study examined two brain regions: the frontal cortex and the hippocampus. Cadmium was given orally for 30 days and also raised levels of 8-oxodGuo, a marker of oxidative DNA damage, in rat brain. Although combined SMF and cadmium exposure worsened some oxidative stress markers compared to cadmium alone, SMF did not change the DNA oxidation marker 8-oxodGuo in cadmium-exposed rats.

Exposure Details

Magnetic Field
128 mT
Exposure Duration
1 hour/day for 30 consecutive days

Exposure Context

This study used 128 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 128 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 640 times the FCC limit

Study Details

The present study was undertaken to determine the effect of co-exposure to static magnetic field (SMF) and cadmium (Cd) on the antioxidant enzymes activity and DNA integrity in rat brain.

Sub-chronic exposure to CdCl (CdCl(2), 40 mg/L, per os) for 30 days

Sub-chronic exposure to CdCl (CdCl(2), 40 mg/L, per os) for 30 days resulted in a significant reduct...

Our data showed that Cd exposure altered the antioxidant enzymes activity and induced oxidative DNA lesions in rat brain. The combined effect of SMF and Cd increased oxidative damage in rat brain as compared with Cd-exposed rats.

Cite This Study
Amara S, Douki T, Garrel C, Favier A, Ben Rhouma K, Sakly M, Abdelmelek H. (2011). Effects of static magnetic field and cadmium on oxidative stress and DNA damage in rat cortex brain and hippocampus. Toxicol Ind Health. 27(2):99-106, 2011.
Show BibTeX
@article{s_2011_effects_of_static_magnetic_596,
  author = {Amara S and Douki T and Garrel C and Favier A and Ben Rhouma K and Sakly M and Abdelmelek H.},
  title = {Effects of static magnetic field and cadmium on oxidative stress and DNA damage in rat cortex brain and hippocampus.},
  year = {2011},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/20837562/},
}
PubMed: 20837562

Cited By (52 papers)

View all 52 citing papers on Semantic Scholar

Quick Questions About This Study

The study used a static magnetic field at 128 mT, applied for 1 hour/day for 30 consecutive days.
Cadmium exposure significantly reduced activity of GPx, CAT, and SOD in the frontal cortex and hippocampus, and decreased total GSH in the frontal cortex.
SMF exposure failed to alter 8-oxodGuo concentration in cadmium-exposed rats.
The combination decreased SOD activity and glutathione levels in the frontal cortex and increased MDA concentration compared with cadmium-exposed rats.
The researchers concluded that cadmium exposure altered antioxidant enzyme activity and induced oxidative DNA lesions in rat brain.