Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone
Saka VP, Chitra V, Narayanasamy D · 2023
Pyrazole derivatives decreased apoptosis in EMR-exposed cortical neurons by reducing reactive oxygen species via mitochondrial damage.
Plain English Summary
Researchers exposed primary cortical neurons from neonatal rats to electromagnetic radiation from a mobile phone at 2100 MHz and 1.6 W/kg SAR for two hours. The study assessed the induction of apoptosis through modulation of pro- and anti-apoptotic genes via a mitochondrial pathway. Pyrazole derivatives reduced apoptosis by lowering reactive oxygen species and modulating apoptotic gene levels. The compounds showed antioxidative and anti-apoptotic properties.
Why This Matters
The authors note that electromagnetic radiation from wireless devices is a potentially growing public health concern. The study investigated the neuronal effects of EMR on primary cortical neurons and the protective role of hispolon and its derivatives as a model for cranial exposure during mobile phone use. The authors suggest that the neuroprotective mechanisms of pyrazole derivatives can be investigated further for potential lead compounds in neuroprotective formulations.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{saka_vp_chitra_v_narayanasamy_d_ce2576,
author = {Saka VP and Chitra V and Narayanasamy D},
title = {Protective role of hispolon and its derivatives against apoptosis in cortical neurons induced by electromagnetic radiation from 4G mobile phone},
year = {2023},
doi = {10.1002/jbt.23351},
}