6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Brain & Nervous System

Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats.

Bioeffects Seen

Gupta SK, Mesharam MK, Krishnamurthy S. · 2018

View Original Abstract
Share:

Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits.

Plain English Summary

Summary written for general audiences

Male rats were exposed to EMR (900, 1800 and 2450 MHz) every day for 1 h for 28 consecutive days. Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits. EMR-2450 MHz caused loss of mitochondrial function and integrity, an increase in amyloid beta expression. There was release of cytochrome-c and activation of apoptotic factors such as caspase-9 and -3 in the hippocampus. Further, there was decrease in levels of acetylcholine, and increase in activity of acetyl cholinesterase, indicating impairment of cholinergic system.

Why This Matters

Cognitive behavior was assessed using novel arm entries in a Y-maze paradigm weekly after exposure. The researchers concluded that EMR-2450 exposure caused cognitive deficit with pathophysiological changes in mitochondrial and cholinergic function and amyloidogenesis.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900, 1800 and 2450 MHz Duration: 1 h for 28 consecutive days

Study Details

To study Electromagnetic radiation of 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats

Male rats were exposed to EMR (900, 1800 and 2450 MHz) every day for 1 h for 28 consecutive days. Th...

Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits. EMR-2450 MHz caused loss o...

Therefore, exposure of EMR-2450 in rats caused cognitive deficit with related pathophysiological changes in mitochondrial and cholinergic function, and amyloidogenesis.

Cite This Study
Gupta SK, Mesharam MK, Krishnamurthy S. (2018). Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats. J Biosci. 43(2):263-276, 2018. .
Show BibTeX
@article{sk_2018_electromagnetic_radiation_2450_mhz_1558,
  author = {Gupta SK and Mesharam MK and Krishnamurthy S.},
  title = {Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats.},
  year = {2018},
  doi = {10.1007/s12038-018-9744-7},
  url = {https://link.springer.com/article/10.1007/s12038-018-9744-7},
}
DOI: 10.1007/s12038-018-9744-7

Cited By (1 paper)

Quick Questions About This Study

Male rats were exposed to EMR at 900, 1800, and 2450 MHz for 1 hour daily over 28 consecutive days.
Cognitive behavior was evaluated using novel arm entries in a Y-maze paradigm every week after the last exposure.
Animals exposed to EMR-2450 MHz exhibited significant cognitive deficits, loss of mitochondrial function and integrity, and increased amyloid beta expression. There was release of cytochrome-c, activation of caspase-9 and -3, decreased acetylcholine, and increased acetylcholinesterase activity.
There was a decrease in acetylcholine levels and an increase in acetylcholinesterase activity, indicating impairment of the cholinergic system.