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Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

DNA & Genetic Damage

Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero.

No Effects Found

Ono T, Saito Y, Komura J, Ikehata H, Tarusawa Y, Nojima T, Goukon K, Ohba Y, Wang J, Fujiwara O, Sato R. · 2004

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This study found no DNA damage from prenatal WiFi-frequency exposure, even at levels higher than typical human use.

Plain English Summary

Summary written for general audiences

Researchers exposed pregnant mice to 2.45 GHz radiofrequency radiation (the same frequency used in microwave ovens and WiFi) for 16 hours daily throughout pregnancy, then examined their offspring for DNA mutations in brain, liver, spleen, and reproductive organs. They found no increase in genetic damage compared to unexposed mice, even at radiation levels significantly higher than typical human exposure. This suggests that prenatal RF exposure at these levels does not cause detectable DNA mutations in developing mammals.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 2.45 GHz Duration: 16 hours a day

Study Details

A possible mutagenic effect of 2.45 GHz radiofrequency exposure was examined using lacZ-transgenic MutaTM mice.

Pregnant animals were exposed intermittently at a whole-body averaged specific absorption rate of 0....

Mutation frequencies at the lacZ gene in spleen, liver, brain, and testis were similar to those obse...

The data suggest that the level of radiofrequency exposure studied is not mutagenic when administered in utero in short repeated bursts.

Cite This Study
Ono T, Saito Y, Komura J, Ikehata H, Tarusawa Y, Nojima T, Goukon K, Ohba Y, Wang J, Fujiwara O, Sato R. (2004). Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero. Tohoku J Exp Med 202(2):93-103, 2004.
Show BibTeX
@article{t_2004_absence_of_mutagenic_effects_3282,
  author = {Ono T and Saito Y and Komura J and Ikehata H and Tarusawa Y and Nojima T and Goukon K and Ohba Y and Wang J and Fujiwara O and Sato R. },
  title = {Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero.},
  year = {2004},
  
  url = {https://www.jstage.jst.go.jp/article/tjem/202/2/202_2_93/_article/-char/ja/},
}

Quick Questions About This Study

A 2004 study found no genetic mutations in baby mice whose mothers were exposed to 2.45 GHz radiation for 16 hours daily during pregnancy. Researchers examined brain, liver, spleen, and reproductive organs and found no DNA damage compared to unexposed offspring.
Research exposing pregnant mice to 2.45 GHz radiation (WiFi frequency) found no DNA mutations across four different organs: brain, liver, spleen, and testis. The study used exposure levels significantly higher than typical human exposure from WiFi devices.
A study exposing pregnant mice to 2.45 GHz radiation for 16 hours daily throughout pregnancy found no genetic damage in their offspring. This extreme exposure duration far exceeds typical human exposure patterns from microwave ovens or wireless devices.
Research found no DNA mutations in testis tissue of mice exposed to 2.45 GHz radiation (microwave oven frequency) during fetal development. The study examined genetic damage in reproductive organs alongside brain, liver, and spleen tissues with similar negative results.
A 2004 study using 2.45 GHz radiation levels significantly higher than typical human exposure found no detectable genetic mutations in mouse offspring. Researchers analyzed DNA quality through nucleotide sequencing and found no differences between exposed and control groups.