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DNA & Genetic Damage

Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields

No Effects Found

Sakurai T, Kiyokawa T, Narita E, Suzuki Y, Taki M, Miyakoshi J · 2011

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Researchers exposed human glial cells to 2.45 GHz RF fields at SARs of 1, 5, and 10 W/kg for 1, 4, and 24 hours and found no evidence that exposure affected gene expression.

Plain English Summary

Summary written for general audiences

The study used DNA microarray to examine gene expression in SVGp12 human glial cells after exposure to 2.45 GHz continuous-wave RF fields at SARs of 1, 5, and 10 W/kg for 1, 4, and 24 hours. Microarray analysis identified 23 assigned and 5 non-assigned gene spots as potentially altered. Follow-up RT-PCR analysis of Twenty-two genes showed no significant alterations in gene expression. The authors concluded that under their experimental conditions they found no evidence that RF field exposure affected gene expression in SVGp12 cells.

Exposure Details

SAR
1, 5, and 10 W/kg
Source/Device
2.45 GHz
Exposure Duration
1, 4, and 24 h

Exposure Context

This study used 1, 5, and 10 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1, 5, and 10 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.45 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.45 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal human glial cell line, SVGp12, using DNA microarray.

Microarray analysis revealed 23 assigned gene spots and 5 non-assigned gene spots as prospective alt...

Under the experimental conditions used in this study, we found no evidence that exposure to RF fields affected gene expression in SVGp12 cells.

Cite This Study
Sakurai T, Kiyokawa T, Narita E, Suzuki Y, Taki M, Miyakoshi J (2011). Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields J Radiat Res. 52(2):185-192, 2011.
Show BibTeX
@article{t_2011_analysis_of_gene_expression_2802,
  author = {Sakurai T and Kiyokawa T and Narita E and Suzuki Y and Taki M and Miyakoshi J},
  title = {Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields},
  year = {2011},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/21343680/},
}
PubMed: 21343680

Cited By (52 papers)

View all 52 citing papers on Semantic Scholar

Quick Questions About This Study

The study used a normal human glial cell line called SVGp12.
Cells were exposed to 2.45 GHz continuous-wave RF fields at SARs of 1, 5, and 10 W/kg for 1, 4, and 24 hours.
Microarray analysis revealed 23 assigned and 5 non-assigned gene spots as prospective altered gene spots.
Follow-up RT-PCR analysis of Twenty-two genes showed no significant alterations in gene expression.
The researchers found no evidence that RF field exposure affected gene expression in SVGp12 cells under the experimental conditions.