Terahertz wave induces the structural and functional changes in voltage-gated calcium channel Cav1.1: A molecular dynamics study
Authors not listed · 2025
The study found that the voltage-gated calcium channel Cav1.1 exhibits high frequency specificity in response to terahertz waves.
Plain English Summary
Researchers constructed a cell membrane model with the voltage-gated calcium channel Cav1.1 embedded. They calculated vibrational spectra of TIP3P molecules and carboxyl and carbonyl groups in the selectivity filter region at 13.4, 48.7, and 53.2 THz. They measured changes in ion channel pore radius distribution and secondary structures of Cav1.1 triggered by external terahertz electromagnetic fields. They used umbrella sampling to assess functional changes via potential of mean force profiles of Ca2+ permeation. The results showed Cav1.1 has highly frequency specificity, emphasizing the importance of terahertz resonance with biomolecules.
Why This Matters
Terahertz waves can induce resonance with many biomolecules, affecting biological activities. The effect of terahertz waves on neuroscience via ion channel proteins has received increasing attention.
Exposure Information
Specific exposure levels were not quantified in this study.
Show BibTeX
@article{terahertz_wave_induces_the_structural_and_functional_changes_in_voltage_gated_calcium_channel_cav11_a_molecular_dynamics_study_ce3284,
author = {Unknown},
title = {Terahertz wave induces the structural and functional changes in voltage-gated calcium channel Cav1.1: A molecular dynamics study},
year = {2025},
}