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Oxidative Stress

Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils.

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Selaković V, Rauš Balind S, Radenović L, Prolić Z, Janać B. · 2013

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Extremely low frequency magnetic fields significantly increased oxidative stress in all tested brain regions of gerbils, with stronger effects in middle-aged animals.

Plain English Summary

Summary written for general audiences

Researchers investigated the effects of extremely low frequency magnetic fields (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brains of 3-month-old (adult) and 10-month-old (middle-aged) Mongolian gerbils. Nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. ELF-MF significantly increased oxidative stress in all tested brain regions, and the effect was higher in middle-aged gerbils and correlated with the value of magnetic induction.

Why This Matters

Three days after exposure ended, the oxidative stress measures moved closer to control levels in all gerbils. In adult gerbils, the effect of ELF-MF at 0.1 mT on nitric oxide level, superoxide production, and superoxide dismutase activity almost fully disappeared, and the index of lipid peroxidation returned to the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present three days after cessation of exposure, but to a lesser degree than those observed immediately after cessation. The researchers described these findings as pointing to the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.

Exposure Details

Magnetic Field
0.1, 0.25 and 0.5 mT
Source/Device
50 Hz
Exposure Duration
7 days

Exposure Context

This study used 0.1, 0.25 and 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1, 0.25 and 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils.

Nitric oxide (NO) level, superoxide (O2 −) production, superoxide dismutase (SOD) activity, and inde...

In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This ef...

These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.

Cite This Study
Selaković V, Rauš Balind S, Radenović L, Prolić Z, Janać B. (2013). Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils. Cell Biochem Biophys. 66(3):513-521, 2013.
Show BibTeX
@article{v_2013_agedependent_effects_of_elfmf_297,
  author = {Selaković V and Rauš Balind S and Radenović L and Prolić Z and Janać B.},
  title = {Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils.},
  year = {2013},
  doi = {10.1007/s12013-012-9498-z},
  url = {https://link.springer.com/article/10.1007/s12013-012-9498-z},
}
DOI: 10.1007/s12013-012-9498-z

Cited By (27 papers)

View all 27 citing papers on Semantic Scholar

Quick Questions About This Study

The study used Mongolian gerbils aged 3 months (adult) and 10 months (middle-aged).
Measurements were taken in the forebrain cortex, striatum, hippocampus, and cerebellum.
Three days after exposure ended, values moved closer to control levels in all gerbils. In middle-aged gerbils the effect was still present, though to a lesser degree than immediately after exposure ended.
The effect was higher in middle-aged gerbils and correlated with the value of magnetic induction.
Researchers measured nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation.