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Oxidative Stress

Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia.

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Rauš Balind S, Selaković V, Radenović L, Prolić Z, Janać B. · 2014

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A 50 Hz, 0.5 mT magnetic field reduced oxidative stress in the brains of gerbils that had suffered global cerebral ischemia.

Plain English Summary

Summary written for general audiences

Researchers studied whether an extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brains of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days, and oxidative stress markers were measured in the forebrain cortex, striatum and hippocampus. Ischemic gerbils exposed to ELF-MF showed increased oxidative stress on the 7th day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals alone, and by the 14th day their oxidative stress parameters were mostly at control levels. The results indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.

Why This Matters

Nitric oxide and superoxide anion production, superoxide dismutase activity, and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus. Ischemia alone raised oxidative stress on both the 7th and 14th day after reperfusion. ELF-MF alone also raised oxidative stress, but only immediately after the exposure ended, and to a greater extent than ischemia. When the two were combined, the field appeared to reduce the oxidative stress caused by ischemia, with levels returning mostly to control values by the 14th day.

Exposure Details

Magnetic Field
0.5 mT
Source/Device
50 Hz
Exposure Duration
7 days

Exposure Context

This study used 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia.

After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF fo...

Ischemia per se increased oxidative stress in the brain on the 7(th) and 14(th) day after reperfusi...

The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.

Cite This Study
Rauš Balind S, Selaković V, Radenović L, Prolić Z, Janać B. (2014). Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia. PLoS One. 2014 Feb 19;9(2):e88921. doi: 10.1371/journal.pone.0088921.
Show BibTeX
@article{s_2014_extremely_low_frequency_magnetic_286,
  author = {Rauš Balind S and Selaković V and Radenović L and Prolić Z and Janać B.},
  title = {Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia.},
  year = {2014},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/24586442/},
}
PubMed: 24586442

Cited By (43 papers)

Quick Questions About This Study

The study used an extremely low frequency magnetic field at 50 Hz and 0.5 mT, applied continuously for 7 days.
Oxidative stress was increased on the 7th day after reperfusion but to a lesser extent than in ischemic or ELF-MF-exposed animals, and was mostly at control levels by the 14th day.
ELF-MF alone increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure.
Researchers examined the forebrain cortex, striatum and hippocampus.
The researchers concluded that the applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain.