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Brain & Nervous System

Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum

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Noda Y, Mori A, Liburdy RP, Packer L · 2000

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A pulsed DC magnetic field increased nitric oxide synthase activity in the rat cerebellum, while AC and static DC fields showed no significant change.

Plain English Summary

Summary written for general audiences

Researchers investigated the effect of pulsed magnetic fields on nitric oxide synthase (NOS) activity in the rat brain. A significant increase in NOS activity was observed in the cerebellum at 111.2±2.0% (P<0.05) for a 1 Gauss (0.1 mT) pulsed DC field, across five separate experiments. Neither AC nor static DC field treatment showed any significant change in NOS activity. In the hippocampus, cortex, medulla oblongata, hypothalamus, striatum, and midbrain, only a slight change or no effect was observed.

Why This Matters

The study used male Sprague-Dawley rats weighing 200-250 g, whose brains were dissected into separate regions. The crude enzyme solutions from each region were treated with pulsed DC, AC, or static DC magnetic fields at 0°C for 1 hour. After exposure, NOS activity was measured as nitrite and nitrate levels generated from incubation with arginine, CaCl2, and β-nicotinamide adenine dinucleotide phosphate. The researchers suggest that pulsed magnetic fields result in a different effect on NOS activity in the cerebellum of the rats.

Exposure Details

Magnetic Field
0.1 mT
Exposure Duration
1 h

Exposure Context

This study used 0.1 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level

Study Details

The effect of pulsed magnetic fields on nitric oxide synthase (NOS) activity in the rat brain was investigated.

Sprague–Dawley rats (male, 200–250 g body weight) brain were dissected regionally, and the crude enz...

Under these experimental conditions, neither AC nor static DC field treatment showed any significant...

These studies suggest that pulsed magnetic fields result in a different effect on NOS activity in the cerebellum of the rats.

Cite This Study
Noda Y, Mori A, Liburdy RP, Packer L (2000). Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum Pathophysiology. 7(2):127-130, 2000.
Show BibTeX
@article{y_2000_pulsed_magnetic_fields_enhance_434,
  author = {Noda Y and Mori A and Liburdy RP and Packer L},
  title = {Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum},
  year = {2000},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0928468000000390},
}

Quick Questions About This Study

A 1 Gauss (0.1 mT) pulsed DC field produced a significant increase in NOS activity in the cerebellum.
Neither AC nor static DC field treatment showed any significant change in NOS activity.
Only a slight change or no effect was observed in the hippocampus, cortex, medulla oblongata, hypothalamus, striatum, and midbrain.
The crude enzyme solutions were treated with magnetic fields at 0°C for 1 hour.
The study used male Sprague-Dawley rats with a body weight of 200-250 g.