The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure
Duan Y, Wang Z, Zhang H, He Y, Lu R, Zhang R, Sun G, Sun X. · 2013
View Original AbstractLotus seedpod procyanidins were found to effectively prevent learning, memory, and oxidative damage in mice exposed to extremely low frequency electromagnetic fields.
Plain English Summary
Researchers investigated whether lotus seedpod procyanidins (LSPCs) given by oral gavage could protect mice from cognitive deficits and oxidative damage caused by extremely low frequency electromagnetic field (ELF-EMF) exposure at 50 Hz and 8 mT for 28 days. A water maze test indicated that learning and memory abilities of the ELF-EMF group deteriorated significantly compared with the control group, but the ELF-EMF + LSPCs90 group had remarkably improved learning and memory abilities compared with the ELF-EMF group. ELF-EMF exposure was associated with significant increases in oxidative stress markers and decreases in antioxidant enzyme activities.
Why This Matters
At 90 mg kg−1, LSPCs treatment significantly increased body weight compared with the ELF-EMF group and helped keep organ indices close to normal. LSPCs at 60 and 90 mg kg−1 decreased MDA, ROS, and NO content and lowered NOS activity, while also significantly augmenting GPx, CAT, and SOD activity in the hippocampus and serum. Examination of brain tissue showed that the number of pyramidal cells in the CA1 and CA3 regions of the hippocampus was significantly greater in LSPCs-treated groups than in the ELF-EMF group. The researchers suggested the protective effect was most likely due to LSPCs' ability to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
Exposure Details
- Magnetic Field
- 8 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 28 days
Exposure Context
This study used 8 mT for magnetic fields:
- 400Kx above the Building Biology guideline of 0.2 mG
- 80Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The present study investigated the effects of lotus seedpod procyanidins (LSPCs) administered by oral gavage on the cognitive deficits and oxidative damage of mice at extremely low frequency electromagnetic field (ELF-EMF) exposure (50 Hz, 8 mT, 28 days).
The results showed that 90 mg kg−1 LSPCs treatment significantly increased body weight compared with...
All the data suggested that the LSPCs can effectively prevent learning and memory damage and oxidative damage caused by the ELF-EMF, most likely through the ability of LSPCs to scavenge oxygen free radicals and to stimulate antioxidant enzyme activity.
Show BibTeX
@article{y_2013_the_preventive_effect_of_244,
author = {Duan Y and Wang Z and Zhang H and He Y and Lu R and Zhang R and Sun G and Sun X.},
title = {The preventive effect of lotus seedpod procyanidins on cognitive impairment and oxidative damage induced by extremely low frequency electromagnetic field exposure},
year = {2013},
url = {https://pubs.rsc.org/en/content/articlelanding/2013/fo/c3fo60116a/unauth#!divAbstract},
}