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Increased vascular permeability in the circumventricular organs of adult rat brain due to stimulation by extremely low frequency magnetic fields

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Gutiérrez-Mercado YK, Cañedo-Dorantes L, Gómez-Pinedo U, Serrano-Luna G, Bañuelos-Pineda J, Feria-Velasco A. · 2013

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Exposure to extremely low frequency magnetic fields increased capillary permeability and vasodilation in rat circumventricular organ capillaries.

Plain English Summary

Summary written for general audiences

Researchers used 96 Wistar male rats divided into three groups of 32 rats each: a control group, a sham group, and an experimental group exposed to extremely low frequency magnetic fields at 120 Hz and 0.66 mT. All animals received colloidal carbon intravenously, and capillary permeability was studied using optical and transmission electron microscopy. In the exposed group, researchers detected an increase in capillary permeability and a significant increase in vascular area, effects not seen in the control or sham groups.

Why This Matters

The study demonstrated effects of extremely low frequency magnetic fields on capillaries of circumventricular organs, reporting a vasodilator effect and an increase in permeability to non-liposoluble substances. Colloidal carbon was administered intravenously to all animals so that researchers could study capillary permeability in circumventricular organs and the blood-brain barrier using optical and transmission electron microscopy. The authors stated that investigating the mechanisms involved is important in order to explain the effects of extremely low frequency magnetic fields on brain vasculature.

Exposure Details

Magnetic Field
0.66 mT
Source/Device
120 Hz

Exposure Context

This study used 0.66 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.66 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 120 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 120 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

In the current study, the effects of extremely low frequency (ELF) MF on the capillaries of some circumventricular organs (CVOs) are demonstrated; a vasodilator effect is reported as well as an increase in their permeability to non‐liposoluble substances.

For this study, 96 Wistar male rats (250 g body mass) were used and divided into three groups of 32...

An increase in capillary permeability to CC was detected in the ELF‐MF‐exposed group as well as a si...

Cite This Study
Gutiérrez-Mercado YK, Cañedo-Dorantes L, Gómez-Pinedo U, Serrano-Luna G, Bañuelos-Pineda J, Feria-Velasco A. (2013). Increased vascular permeability in the circumventricular organs of adult rat brain due to stimulation by extremely low frequency magnetic fields Bioelectromagnetics. 34(2):145-155, 2013.
Show BibTeX
@article{yk_2013_increased_vascular_permeability_in_255,
  author = {Gutiérrez-Mercado YK and Cañedo-Dorantes L and Gómez-Pinedo U and Serrano-Luna G and Bañuelos-Pineda J and Feria-Velasco A.},
  title = {Increased vascular permeability in the circumventricular organs of adult rat brain due to stimulation by extremely low frequency magnetic fields},
  year = {2013},
  doi = {10.1002/bem.21757},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.21757},
}
DOI: 10.1002/bem.21757

Cited By (6 papers)

Quick Questions About This Study

The study used 96 Wistar male rats with a body mass of 250 g, divided into three groups of 32 rats each.
The experimental group was exposed to 120 Hz harmonic waves at 0.66 mT, delivered using Helmholtz coils.
An increase in capillary permeability and a significant increase in vascular area were detected in the exposed group, and neither effect appeared in the control or sham groups.
The authors stated that investigating the mechanisms involved is important in order to explain the effects of extremely low frequency magnetic fields on brain vasculature.
Capillary permeability was studied by administering colloidal carbon intravenously and examining tissue using optical and transmission electron microscopy.