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Oxidative Stress

Vitamin C protects rat cerebellum and encephalon from oxidative stress following exposure to radiofrequency wave generated by a BTS antenna model

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Akbari A, Jelodar G, Nazifi S · 2014

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Radiofrequency wave exposure decreased antioxidant enzyme activity and increased MDA in rat brain tissue, while vitamin C supplementation partially reversed these effects.

Plain English Summary

Summary written for general audiences

Researchers exposed adult male Sprague-Dawley rats to radiofrequency waves generated by a base transceiver station antenna model and measured oxidative stress markers in the cerebellum and encephalon. Antioxidant enzymes measured included glutathione peroxidase, superoxide dismutase, and catalase, along with malondialdehyde (MDA). Exposure to radiofrequency waves decreased antioxidant enzyme activity and increased MDA compared with the control groups. Vitamin C supplementation improved antioxidant enzyme activity and reduced MDA in the group that also received radiofrequency wave exposure.

Why This Matters

Rats were randomly divided into four equal groups: a control group, a control group receiving vitamin C, a radiofrequency wave-exposed group, and a group exposed to radiofrequency waves while also receiving vitamin C. Vitamin C was administered as L-ascorbic acid at 200 mg/kg of body weight per day by gavage for 45 days. At the end of the experiment, brain tissues were removed and stored at minus 70 degrees Celsius for enzyme and MDA measurement. The researchers concluded that radiofrequency waves cause oxidative stress in the brain and that vitamin C improves antioxidant enzyme activity and decreases MDA.

Exposure Details

Power Density
0.6789 mW/cm²
Source/Device
900 MHz RFW from BTS antenna model
Exposure Duration
continuous for 4 h/day for 45 days

Exposure Context

This study used 0.6789 mW/cm² for radio frequency:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.6789 mW/cm²Extreme Concern - 1,000 µW/m²FCC Limit - 10M µW/m²Effects observed in the Extreme Concern range (Building Biology)FCC limit is 1 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

This study was conducted to evaluate the effect of RFW-induced oxidative stress in the cerebellum and encephalon and the prophylactic effect of vitamin C on theses tissues by measuring the antioxidant enzymes activity, including: glutathione peroxidase, superoxide dismutase, catalase, and malondialdehyde (MDA).

Thirty-two adult male Sprague-Dawley rats were randomly divided into four equal groups. The control ...

The results indicate that exposure to RFW in the test group decreased antioxidant enzymes activity a...

It can be concluded that RFW causes oxidative stress in the brain and vitamin C improves the antioxidant enzymes activity and decreases MDA.

Cite This Study
Akbari A, Jelodar G, Nazifi S (2014). Vitamin C protects rat cerebellum and encephalon from oxidative stress following exposure to radiofrequency wave generated by a BTS antenna model Toxicol Mech Methods. 24(5):347-352, 2014.
Show BibTeX
@article{a_2014_vitamin_c_protects_rat_59,
  author = {Akbari A and Jelodar G and Nazifi S},
  title = {Vitamin C protects rat cerebellum and encephalon from oxidative stress following exposure to radiofrequency wave generated by a BTS antenna model},
  year = {2014},
  doi = {10.3109/15376516.2014.910852},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15376516.2014.910852},
}
DOI: 10.3109/15376516.2014.910852

Cited By (33 papers)

Quick Questions About This Study

Adult male Sprague-Dawley rats were randomly divided into four equal groups.
Researchers measured oxidative stress markers in the cerebellum and encephalon.
Exposure decreased antioxidant enzyme activity and increased MDA compared with control groups.
Vitamin C improved antioxidant enzyme activity and reduced MDA in radiofrequency wave-exposed rats compared with those that did not receive vitamin C.
Vitamin C was given as L-ascorbic acid at 200 mg/kg of body weight per day by gavage for 45 days.