Effects of extremely low frequency electromagnetic field (ELF-EMF) on catalase, cytochrome P450 and nitric oxide synthase in erythro-leukemic cells.
Patruno A, Tabrez S, Pesce M, Shakil S, Kamal MA, Reale M · 2015
View Original AbstractELF-EMF exposure produced a significant modulation of iNOS, CAT, and cytochrome P450 protein expression in myelogenous leukemia cells.
Plain English Summary
Researchers evaluated the effect of extremely low frequency electromagnetic field exposure on catalase, cytochrome P450, and inducible nitric oxide synthase activity and protein expression in the myelogenous leukemia cell line K562. A significant modulation of iNOS, CAT, and cytochrome P450 protein expression was recorded in both stimulated and non-stimulated cell lines following ELF-EMF exposure. Changes in the kinetic parameters of these enzymes in response to ELF-EMF indicated an interaction between ELF-EMF and the enzymological system.
Why This Matters
The study used the myelogenous leukemia cell line K562 and examined catalase, cytochrome P450, and inducible nitric oxide synthase activity and their protein expression. The researchers proposed that ELF-EMFs could interfere with chemical reactions involving free radical production, which may help explain how these fields influence cellular behavior. Cells normally maintain a balance between the production and elimination of reactive oxygen and nitrogen species, and a disruption of this balance has been linked to conditions including neurodegenerative diseases, aging, and cancer. The authors noted that there is disagreement about whether a causal or coincidental relationship exists between ELF-EMF exposure and leukemia development. The researchers suggested that these findings might help establish a mechanistic framework for understanding the possible effects of ELF-EMF on health at the molecular level.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 24 h
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
Extremely low frequency electromagnetic fields (ELF-EMFs) are widely employed in electrical appliances and different equipment such as television sets, mobile phones, computers and microwaves. The molecular mechanism through which ELF-EMFs can influence cellular behavior is still unclear. A hypothesis is that ELF-EMFs could interfere with chemical reactions involving free radical production. Under physiologic conditions, cells maintain redox balance through production of ROS/RNS and antioxidant molecules. The altered balance between ROS generation and elimination plays a critical role in a variety of pathologic conditions including neurodegenerative diseases, aging and cancer. Actually, there is a disagreement as to whether there is a causal or coincidental relationship between ELF-EMF exposure and leukemia development. Increased ROS levels have been observed in several hematopoietic malignancies including acute and chronic myeloid leukemias.
In our study, the effect of ELF-EMF exposure on catalase, cytochrome P450 and inducible nitric oxide...
A significant modulation of iNOS, CAT and Cyt P450 protein expression was recorded as a result of EL...
These new insights might be important in establishing a mechanistic framework at the molecular level within which the possible effects of ELF-EMF on health can be understood.
Show BibTeX
@article{a_2015_effects_of_extremely_low_441,
author = {Patruno A and Tabrez S and Pesce M and Shakil S and Kamal MA and Reale M},
title = {Effects of extremely low frequency electromagnetic field (ELF-EMF) on catalase, cytochrome P450 and nitric oxide synthase in erythro-leukemic cells. },
year = {2015},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0024320514009667},
}