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Oxidative Stress

Effects of extremely low frequency electromagnetic fields on paraoxonase serum activity and lipid peroxidation metabolites in rat.

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Seifirad S, Farzampour S, Nourbakhsh M, Amoli MM, Razzaghy-Azar M, Larijani B · 2014

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Exposure to extremely low frequency electromagnetic fields increased lipid peroxidation and may impair oxidant-antioxidant function in rats.

Plain English Summary

Summary written for general audiences

Single exposure significantly increased lipid peroxidation and also increased antioxidant serum activity, including HDL, paraoxonase activity, and serum total antioxidant capacity. Chronic exposure increased lipid peroxidation, affected the antioxidant system, and led to irreversible changes, while acute exposure tended toward reversible alterations. The researchers noted that antioxidant capability was dependent on the duration and continuity of ELF-MF exposure.

Why This Matters

Some rat groups were sacrificed immediately after exposure and others 72 hours later, allowing researchers to look at both immediate and delayed effects. Free fatty acid levels were significantly increased after both single and two weeks of exposure. The study also investigated how time affected the remodeling of the antioxidant system.

Exposure Details

Magnetic Field
0.5 mT
Source/Device
60 Hz
Exposure Duration
Fourteen days

Exposure Context

This study used 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 60 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

This study was therefore undertaken to examine the effects of ELF-MF on paraoxonase (PON) activity, antioxidant capacity and lipid peroxidation metabolites. Effects of time on remodeling of antioxidant system were also investigated in this study.

Seventy five Wistar rats were randomly allocated into five groups as follows: 1) Sham exposure, 2) S...

Single ELF-MF exposure significantly increased lipid peroxidation (CD and MDA) and increased antioxi...

According to the results of this study, ELF-MF exposure could impair oxidant-antioxidant function and might increase oxidative stress and lipid peroxidation. Antioxidant capability was dependent on the duration and continuity of ELF-MF exposure.

Cite This Study
Seifirad S, Farzampour S, Nourbakhsh M, Amoli MM, Razzaghy-Azar M, Larijani B (2014). Effects of extremely low frequency electromagnetic fields on paraoxonase serum activity and lipid peroxidation metabolites in rat. J Diabetes Metab Disord. 13(1):85, 2014.
Show BibTeX
@article{s_2014_effects_of_extremely_low_458,
  author = {Seifirad S and Farzampour S and Nourbakhsh M and Amoli MM and Razzaghy-Azar M and Larijani B},
  title = {Effects of extremely low frequency electromagnetic fields on paraoxonase serum activity and lipid peroxidation metabolites in rat.},
  year = {2014},
  doi = {10.1186/s40200-014-0085-2},
  url = {https://link.springer.com/article/10.1186/s40200-014-0085-2},
}
DOI: 10.1186/s40200-014-0085-2

Cited By (18 papers)

Quick Questions About This Study

The study used seventy five Wistar rats randomly allocated into five groups.
Rats were exposed to a 60 Hz electromagnetic field.
A single exposure significantly increased lipid peroxidation, measured as CD and MDA.
Chronic exposure led to irreversible changes, while acute exposure tended toward reversible alterations.
The researchers concluded that ELF-MF exposure could impair oxidant-antioxidant function and might increase oxidative stress and lipid peroxidation.