Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field.
Kim JH, Kim HJ, Yu DH, Kweon HS, Huh YH, Kim HR. · 2017
View Original AbstractExposure to 835 MHz RF-EMF reduced the density and synapsin protein levels of synaptic vesicles in the cortical neurons of mice.
Plain English Summary
Researchers studied the effects of RF-EMF exposure on synaptic vesicles in the cortical neurons of mice. C57 BL/6 mice were exposed to 835 MHz RF-EMF at 4.0 W/kg SAR for 5 hours daily. The density of synaptic vesicles was significantly decreased in the presynaptic boutons of cortical neurons after exposure. The expression of synapsins I/II genes and proteins was also significantly decreased in exposed mice.
Why This Matters
The study focused on synaptic vesicles, which store neurotransmitters at axon terminals or synaptic boutons. Researchers used electron microscopy and bio-high voltage electron microscopy to estimate the numbers and size of synaptic vesicles in cortical neurons. The researchers suggested that the observed alterations in synaptic vesicles and synapsin levels may result in alterations of neurotransmitters in the cerebral cortex.
Exposure Details
- SAR
- 4 W/kg
- Source/Device
- 835 MHz
- Exposure Duration
- 5 h daily
Exposure Context
This study used 4 W/kg for SAR (device absorption):
- 10x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
We studied the effects of radiofrequency electromagnetic fields (RF-EMFs) exposure on neuronal functions of mice.
we focused on RF-EMF effects on synaptic vesicles (SVs), which store neurotransmitters at axon termi...
The density of the SVs (number /10 μm2 or 40 μm3) was significantly decreased in the presynaptic bou...
The present study suggested that alteration of SVs and Syn levels may result in alterations of neurotransmitters in the cerebral cortex following RF-EMF exposure.
Show BibTeX
@article{jh_2017_changes_in_numbers_and_1102,
author = {Kim JH and Kim HJ and Yu DH and Kweon HS and Huh YH and Kim HR.},
title = {Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field.},
year = {2017},
url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186416},
}