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Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field.

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Kim JH, Kim HJ, Yu DH, Kweon HS, Huh YH, Kim HR. · 2017

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Cell phone-frequency radiation reduced brain communication structures in mice at exposure levels achievable during everyday device use.

Plain English Summary

Summary written for general audiences

Korean researchers exposed mice to cell phone-frequency radiation (835 MHz) for 5 hours daily and examined changes in brain cells. They found that this exposure significantly reduced the number of synaptic vesicles (tiny containers that store brain chemicals) and decreased levels of proteins needed for proper brain communication. These changes suggest that radiofrequency radiation may disrupt how brain cells communicate with each other.

Why This Matters

This study provides compelling evidence that radiofrequency radiation can alter fundamental brain structures at the cellular level. The researchers used a 4.0 W/kg SAR exposure level, which is four times higher than the current FCC limit for cell phones (1.6 W/kg), but well within the range that could occur during prolonged phone calls or when devices are used close to the body. What makes this research particularly significant is that it examined synaptic vesicles and synapsin proteins, which are critical for neurotransmitter release and brain communication. The science demonstrates that RF-EMF exposure can reduce both the number of these vesicles and the proteins that regulate them, potentially affecting cognitive function and neural signaling. This adds to a growing body of research showing that wireless radiation affects brain structure and function, challenging the industry's position that non-thermal effects don't exist.

Exposure Details

SAR
4 W/kg
Source/Device
835 MHz
Exposure Duration
5 h daily

Exposure Context

This study used 4 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 4 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern rangeFCC limit is 0x higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 835 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 835 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

We studied the effects of radiofrequency electromagnetic fields (RF-EMFs) exposure on neuronal functions of mice.

we focused on RF-EMF effects on synaptic vesicles (SVs), which store neurotransmitters at axon termi...

The density of the SVs (number /10 μm2 or 40 μm3) was significantly decreased in the presynaptic bou...

The present study suggested that alteration of SVs and Syn levels may result in alterations of neurotransmitters in the cerebral cortex following RF-EMF exposure.

Cite This Study
Kim JH, Kim HJ, Yu DH, Kweon HS, Huh YH, Kim HR. (2017). Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field. PLoS One. 2017 Oct 18;12(10):e0186416.
Show BibTeX
@article{jh_2017_changes_in_numbers_and_1102,
  author = {Kim JH and Kim HJ and Yu DH and Kweon HS and Huh YH and Kim HR.},
  title = {Changes in numbers and size of synaptic vesicles of cortical neurons induced by exposure to 835 MHz radiofrequency-electromagnetic field.},
  year = {2017},
  
  url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186416},
}

Quick Questions About This Study

Yes, 835 MHz radiation significantly reduces synaptic vesicles in brain cells. Korean researchers found that 5-hour daily exposure decreased the number of these tiny containers that store brain chemicals, potentially disrupting how neurons communicate with each other.
Research shows that 835 MHz radiation significantly decreases synapsins I and II proteins in cortical neurons. These proteins are essential for proper brain cell communication, and their reduction suggests radiofrequency exposure may impair neurotransmitter function.
Korean researchers found brain cell changes after 5 hours of daily 835 MHz exposure in mice. The study demonstrated significant reductions in synaptic vesicles and communication proteins, suggesting relatively short exposure periods can impact neural function.
835 MHz radiation exposure alters neurotransmitter systems by reducing synaptic vesicles and synapsins proteins that control brain chemical release. Researchers concluded these changes likely disrupt normal neurotransmitter function in the cerebral cortex following radiofrequency exposure.
Yes, 835 MHz radiation specifically affects presynaptic boutons, the nerve terminals where brain cells communicate. Research found significantly decreased synaptic vesicle density in these critical connection points, suggesting targeted disruption of neural communication pathways.