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Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.

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Maskey D, Kim M, Aryal B, Pradhan J, Choi IY, Park KS, Son T, Hong SY, Kim SB, Kim HG, Kim MJ. · 2010

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One month of cell phone frequency radiation caused near-complete loss of memory-critical brain cells in mice at exposure levels within current safety limits.

Plain English Summary

Summary written for general audiences

Researchers exposed mice to cell phone frequency radiation (835 MHz) for up to one month and examined brain tissue in the hippocampus, a region critical for memory and learning. They found significant damage to calcium-binding proteins and near-complete loss of pyramidal brain cells in the CA1 area after one month of exposure. This cellular damage could disrupt normal brain functions including memory formation and neural connectivity.

Why This Matters

This study reveals concerning evidence of brain cell damage from radiofrequency radiation at levels comparable to cell phone exposure. The 835 MHz frequency sits squarely within the cellular band, and the SAR levels tested (1.6 and 4.0 W/kg) bracket the current safety limit of 2.0 W/kg in many countries. What makes these findings particularly significant is the location of the damage - the hippocampus CA1 region is essential for memory consolidation and spatial navigation. The researchers observed what they described as 'almost complete loss' of pyramidal cells after just one month of exposure. While this was an animal study, the hippocampus structure and function is remarkably similar between mice and humans. The science demonstrates that chronic RF exposure can cause measurable brain cell damage at absorption rates within current regulatory limits, raising serious questions about the adequacy of existing safety standards for devices we use daily.

Exposure Details

SAR
4, 1.6 W/kg
Source/Device
835 MHz
Exposure Duration
continuous exposure for up to one month

Exposure Context

This study used 4, 1.6 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 4, 1.6 W/kgExtreme Concern0.1 W/kgFCC Limit1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 1x higher than this exposure level

Study Details

To study the effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.

CB and CR expression were measured with immunohistochemistry in the hippocampus of mice after EMF ex...

Body weights did not change significantly. CB immunoreactivity (IR) displayed moderate staining of c...

Cite This Study
Maskey D, Kim M, Aryal B, Pradhan J, Choi IY, Park KS, Son T, Hong SY, Kim SB, Kim HG, Kim MJ. (2010). Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain. Brain Res. 1313:232-241, 2010a.
Show BibTeX
@article{d_2010_effect_of_835_mhz_137,
  author = {Maskey D and Kim M and Aryal B and Pradhan J and Choi IY and Park KS and Son T and Hong SY and Kim SB and Kim HG and Kim MJ. },
  title = {Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.},
  year = {2010},
  
  url = {https://www.sciencedirect.com/science/article/abs/pii/S0006899309025980},
}

Quick Questions About This Study

Researchers exposed mice to cell phone frequency radiation (835 MHz) for up to one month and examined brain tissue in the hippocampus, a region critical for memory and learning. They found significant damage to calcium-binding proteins and near-complete loss of pyramidal brain cells in the CA1 area after one month of exposure. This cellular damage could disrupt normal brain functions including memory formation and neural connectivity.