Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.
Maskey D, Kim M, Aryal B, Pradhan J, Choi IY, Park KS, Son T, Hong SY, Kim SB, Kim HG, Kim MJ. · 2010
View Original AbstractExposure to 835 MHz radiofrequency radiation for one month was associated with almost complete loss of pyramidal cells in the CA1 area of the mouse hippocampus.
Plain English Summary
Researchers measured calbindin (CB) and calretinin (CR) expression in the hippocampus of mice after exposure to 835 MHz electromagnetic fields at various durations and absorption rates. Exposure conditions included 1 hour per day for 5 days at a specific absorption rate of 1.6 W/kg, 1 hour per day for 5 days at 4.0 W/kg, 5 hours per day for 1 day at 1.6 W/kg, 5 hours per day for 1 day at 4.0 W/kg, and daily exposure for 1 month at 1.6 W/kg. Exposure for 1 month produced almost complete loss of pyramidal cells in the CA1 area. Body weights did not change significantly across the exposure groups.
Why This Matters
CB immunoreactivity showed moderate staining of cells in the cornu ammonis areas and prominently stained granule cells under normal conditions. CR immunoreactivity revealed prominently stained pyramidal cells with dendrites running perpendicularly in the CA area. The researchers suggested that differences in calcium binding proteins could cause changes in cellular calcium levels, which could have a deleterious effect on normal hippocampal functions concerned with neuronal connectivity and integration.
Exposure Details
- SAR
- 4, 1.6 W/kg
- Source/Device
- 835 MHz
- Exposure Duration
- continuous exposure for up to one month
Exposure Context
This study used 4, 1.6 W/kg for SAR (device absorption):
- 4x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To study the effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.
CB and CR expression were measured with immunohistochemistry in the hippocampus of mice after EMF ex...
Body weights did not change significantly. CB immunoreactivity (IR) displayed moderate staining of c...
Show BibTeX
@article{d_2010_effect_of_835_mhz_137,
author = {Maskey D and Kim M and Aryal B and Pradhan J and Choi IY and Park KS and Son T and Hong SY and Kim SB and Kim HG and Kim MJ. },
title = {Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.},
year = {2010},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0006899309025980},
}