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Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic D1 receptor.

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Shin EJ, Nguyen XK, Nguyen TT, Pham DT, Kim HC. · 2011

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Repeated extremely low frequency magnetic field exposure induced lasting brain changes in mice via dopaminergic D1 receptor activation.

Plain English Summary

Summary written for general audiences

Researchers examined whether repeated extremely low frequency magnetic field exposure induces fos-related antigen immunoreactivity in the striatum and nucleus accumbens of mice. Exposure at 0.3 or 2.4 mT for 1 hour per day over fourteen consecutive days significantly induced hyperlocomotor activity and fos-related antigen immunoreactivity in a field intensity-dependent manner. The fos-related antigen immunoreactivity lasted for at least 1 year, while locomotor activity returned near control level 3 months after the final exposure.

Why This Matters

The study found that blocking the dopaminergic D1 receptor significantly reduced both the hyperlocomotor activity and fos-related antigen immunoreactivity caused by the magnetic field exposure. Blocking the D2 receptor did not produce the same attenuation, suggesting the D1 receptor plays a specific role in these effects. The researchers suggest that repeated ELF-MF exposure leads to prolonged locomotor stimulation and long-term expression of fos-related antigen in the striatal complex via D1 receptor stimulation.

Exposure Details

Magnetic Field
0.3 or 2.4 mT
Source/Device
60 Hz
Exposure Duration
1 h/day, for consecutive fourteen days

Exposure Context

This study used 0.3 or 2.4 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.3 or 2.4 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 2 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 60 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 60 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

we examined whether repeated ELF-MF exposure induces FRA-immunoreactivity (FRA-IR) in the striatum and nucleus accumbens (striatal complex) of the mice.

Repeated exposure to ELF-MF (0.3 or 2.4 mT, 1 h/day, for consecutive fourteen days) significantly in...

Pretreatment with SCH23390, a dopaminergic D1 receptor antagonist, but not with sulpiride, a dopamin...

Our results suggest that repeated exposure to ELF-MF leads to prolonged locomotor stimulation and long-term expression of FRA in the striatal complex of the mice via stimulation of dopaminergic D1 receptor.

Cite This Study
Shin EJ, Nguyen XK, Nguyen TT, Pham DT, Kim HC. (2011). Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic D1 receptor. Exp Neurobiol. 20(3):130-6, 2011.
Show BibTeX
@article{ej_2011_exposure_to_extremely_low_301,
  author = {Shin EJ and Nguyen XK and Nguyen TT and Pham DT and Kim HC.},
  title = {Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic D1 receptor.},
  year = {2011},
  
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214769/},
}

Quick Questions About This Study

The study examined the striatum and nucleus accumbens, referred to together as the striatal complex.
Mice were exposed to magnetic fields of 0.3 or 2.4 mT for 1 hour per day over fourteen consecutive days.
Fos-related antigen immunoreactivity lasted for at least 1 year, while locomotor activity returned near control level 3 months after the final exposure.
Blocking the D1 receptor significantly reduced both hyperlocomotor activity and fos-related antigen immunoreactivity, while blocking the D2 receptor did not.
Hyperlocomotor activity and fos-related antigen immunoreactivity were induced in a field intensity-dependent manner.