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Oxidative Stress

Protective properties of Myrtus communis extract against oxidative effects of extremely low-frequency magnetic fields on rat plasma and hemoglobin.

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Seif F, Bayatiani MR, Ansarihadipour H, Habibi G, Sadelaji S · 2018

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Myrtus communis extract protected rat blood from oxidative damage caused by extremely low-frequency magnetic field exposure.

Plain English Summary

Summary written for general audiences

Researchers divided adult male rats into three groups: a control group, a group exposed to extremely low-frequency magnetic fields (ELFMF), and a group given Myrtus communis extract before ELFMF exposure. The magnetic field was set at 0.7 mT and 50 Hz, applied for two hours a day for one month. ELFMF exposure decreased plasma antioxidant power and significantly increased markers of oxidative damage, including protein carbonyl, methemoglobin, and hemichrome concentrations. Administration of M. communis extract increased antioxidant power and decreased plasma protein carbonyl, methemoglobin, and hemichrome concentrations.

Why This Matters

The study measured several markers in rat blood to assess oxidative stress, including hemoglobin structure, methemoglobin and hemichrome levels, protein carbonyl levels, and plasma antioxidant power (FRAP). Oxidative changes to hemoglobin from ELFMF exposure were reflected in reduced optical density at 340 nm and 420 nm, indicating changes in globin-heme and heme-heme interactions. Treatment with M. communis extract was associated with a significant increase in hemoglobin absorbance at 340, 420, 542, and 577 nm, suggesting protection against ELFMF-induced oxidative stress in red blood cells. The extract was injected intraperitoneally at a dose of 0.5 mg/kg before each ELFMF exposure session. An artificial neural network (ANN) analysis identified optical absorption of hemoglobin at 520, 577, 542, and 630 nm, along with methemoglobin and hemichrome concentrations, as the most important parameters for predicting oxyhemoglobin concentration.

Exposure Details

Magnetic Field
0.7 mT
Source/Device
50 Hz
Exposure Duration
2 hours a day for 1 month

Exposure Context

This study used 0.7 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.7 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 4 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

This study investigates the protective properties of Myrtus communis extract against the oxidative effects of extremely low-frequency magnetic fields (ELFMF). Also, this study is aimed to analyze the conformational changes of hemoglobin, oxidative damages to plasma proteins and antioxidant power of plasma following exposure to ELFMF.

Adult male rats were divided into 3 groups: (1) control, (2) ELFMF exposure, and (3) ELFMF exposure ...

Exposure to ELFMF decreased the FRAP which was in concomitant with a significant increase in plasma ...

Myrtus communis extract enhances the ability of erythrocytes and plasma to deal with oxidative conditions during exposure to ELFMF. Also, ANN analysis can predict the most important parameters in relation to Hb structure during oxidative stress.

Cite This Study
Seif F, Bayatiani MR, Ansarihadipour H, Habibi G, Sadelaji S (2018). Protective properties of Myrtus communis extract against oxidative effects of extremely low-frequency magnetic fields on rat plasma and hemoglobin. Int J Radiat Biol. 2018 Nov 29:1-22. doi: 10.1080/09553002.2019.1542182.
Show BibTeX
@article{f_2018_protective_properties_of_myrtus_457,
  author = {Seif F and Bayatiani MR and Ansarihadipour H and Habibi G and Sadelaji S},
  title = {Protective properties of Myrtus communis extract against oxidative effects of extremely low-frequency magnetic fields on rat plasma and hemoglobin.},
  year = {2018},
  doi = {10.1080/09553002.2019.1542182},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2019.1542182},
}
DOI: 10.1080/09553002.2019.1542182

Cited By (1 paper)

Quick Questions About This Study

The magnetic field was set at 0.7 mT and 50 Hz and was produced by a Helmholtz coil.
ELFMF exposure decreased plasma antioxidant power and caused significant increases in protein carbonyl, methemoglobin, and hemichrome concentrations.
Administration of M. communis extract increased antioxidant power values and decreased plasma protein carbonyl, methemoglobin, and hemichrome concentrations.
The extract was injected intraperitoneally at a dose of 0.5 mg/kg before exposure to the magnetic field.
ANN analysis found that hemoglobin optical absorption at 520, 577, 542, and 630 nm and concentrations of methemoglobin and hemichrome were the most important parameters for predicting oxyhemoglobin concentration.