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Oxidative Stress

Effects of exposure to 50 Hz electric field at different strengths on oxidative stress and antioxidant enzyme activities in the brain tissue of guinea pigs.

No Effects Found

Türközer Z, Güler G, Seyhan N. · 2008

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Exposure to 50 Hz electric fields at multiple strengths did not produce statistically significant changes in lipid peroxidation or antioxidant enzyme activities in guinea pig brain tissue.

Plain English Summary

Summary written for general audiences

Researchers aimed to evaluate the effects of varied 50 Hz electric field exposure on lipid peroxidation and antioxidant enzyme activities in guinea pig brain homogenates. Guinea pigs were exposed to electric fields ranging from 2 to 5 kV/m for three days, eight hours per day, in both vertical and horizontal directions. No statistically significant differences were found between exposed and sham groups in lipid peroxidation levels or enzyme activities at any field strength or direction. Comparisons between vertical and horizontal exposure directions also showed no significant differences.

Why This Matters

The study measured malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, xanthine oxidase, myeloperoxidase, and adenosine deaminase activities in brain tissue. The authors reported observed effects that were not statistically significant and recommended further research on ELF electric field effects.

Exposure Details

Electric Field
2000, 2500, 3000, 3500, 4000, 4500, 5000 V/m
Source/Device
50 Hz
Exposure Duration
three days, 8 h a day

Exposure Context

This study used 2000, 2500, 3000, 3500, 4000, 4500, 5000 V/m for electric fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to evaluate the possible effects of varied exposure to 50 Hz extremely low frequency (ELF) electric field (EF) on the lipid peroxidation levels and antioxidant enzyme activities in the brain homogenates of guinea pigs. Subjects were exposed to 2 kV/m, 2.5 kV/m, 3 kV/m, 3.5 kV/m, 4 kV/m, 4.5 kV/m and 5 kV/m electric fields for three days, 8 h a day in both vertical and horizontal directions.

Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-P...

Although the study showed several positive but non-significant findings (p > 0.05), we did not find ...

The present study observed effects of 50 Hz EF exposure on lipid peroxidation levels and antioxidant defense mechanisms but these were not statistically significant at the 95% confidence level. Further research on the effects ELF-EF exposure on lipid peroxidation levels and antioxidant defence mechanisms are warranted.

Cite This Study
Türközer Z, Güler G, Seyhan N. (2008). Effects of exposure to 50 Hz electric field at different strengths on oxidative stress and antioxidant enzyme activities in the brain tissue of guinea pigs. Int J Radiat Biol. 84(7):581-590, 2008.
Show BibTeX
@article{z_2008_effects_of_exposure_to_2832,
  author = {Türközer Z and Güler G and Seyhan N.},
  title = {Effects of exposure to 50 Hz electric field at different strengths on oxidative stress and antioxidant enzyme activities in the brain tissue of guinea pigs.},
  year = {2008},
  doi = {10.1080/09553000802203606},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553000802203606},
}
DOI: 10.1080/09553000802203606

Cited By (18 papers)

Quick Questions About This Study

The aim was to evaluate the possible effects of varied exposure to 50 Hz extremely low frequency electric field on lipid peroxidation levels and antioxidant enzyme activities in the brain homogenates of guinea pigs.
Subjects were exposed to 2 kV/m, 2.5 kV/m, 3 kV/m, 3.5 kV/m, 4 kV/m, 4.5 kV/m and 5 kV/m electric fields for three days, 8 h a day in both vertical and horizontal directions.
Malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, xanthine oxidase, myeloperoxidase, and adenosine deaminase activities were measured.
The study did not find significant differences among all exposed groups and sham groups in lipid peroxidation levels and enzyme activities at all strengths and in both directions.
Comparisons between vertical and horizontal exposure directions showed no significant differences.