Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: effects on neurotrophic factors and neuronal density.
Tasset I, Medina FJ, Jimena I, Agüera E, Gascón F, Feijóo M, Sánchez-López F, Luque E, Peña J, Drucker-Colín R, Túnez I. · 2012
View Original AbstractExtremely low-frequency electromagnetic fields improved neurological scores and reduced neuronal loss in rats with a Huntington's disease model.
Plain English Summary
Researchers investigated the neuroprotective effects of extremely low-frequency electromagnetic fields (ELFEF) in a rat model of Huntington's disease induced by 3-nitropropionic acid (3NP). Rats were given 3NP over four consecutive days at 20 mg/kg body weight, and ELFEF at 60 Hz and 0.7 mT was applied over 21 days, starting after the last injection. Rats treated with 3NP showed significant differences in behavior, neurotrophic factor levels, oxidative stress biomarkers, and reduced neuronal density compared with neuronal controls. ELFEF improved neurological scores, enhanced neurotrophic factor levels, and reduced both oxidative damage and neuronal loss in 3NP-treated rats.
Why This Matters
The study used Wistar rats, monitoring behavior patterns, neurotrophic factor changes, cell damage, and oxidative stress biomarker levels. The 3NP chemical was used to create a rat model resembling Huntington's disease, and ELFEF treatment began only after the 3NP injections were completed. Among the measured outcomes, ELFEF enhanced neurotrophic factor levels and reduced oxidative damage in the 3NP-treated rats.
Exposure Details
- Magnetic Field
- 0.7 mT
- Source/Device
- 60 Hz
- Exposure Duration
- 2 x 2 h/day ( in the morning and in the afternoon) for 21 days
Exposure Context
This study used 0.7 mT for magnetic fields:
- 35Kx above the Building Biology guideline of 0.2 mG
- 7Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
This study was undertaken to investigate the neuroprotective effects of ELFEF in a rat model of 3-nitropropionic acid (3NP)-induced Huntington's disease.
Behavior patterns were evaluated, and changes in neurotrophic factor, cell damage, and oxidative str...
Rats treated with 3NP exhibited significantly different behavior in the open field test (OFT) and th...
Show BibTeX
@article{i_2012_neuroprotective_effects_of_extremely_306,
author = {Tasset I and Medina FJ and Jimena I and Agüera E and Gascón F and Feijóo M and Sánchez-López F and Luque E and Peña J and Drucker-Colín R and Túnez I.},
title = {Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: effects on neurotrophic factors and neuronal density.},
year = {2012},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0306452212001777},
}