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Protective effect of melatonin and vitamin E against prooxidative action of iron ions and static magnetic field

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Jajte J, Zmyślony M, Rajkowska E. · 2003

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Both melatonin and vitamin E reduced lipid peroxidation in rat lymphocytes exposed to iron ions and a 7 mT static magnetic field, with vitamin E proving more effective.

Plain English Summary

Summary written for general audiences

Researchers examined whether melatonin and vitamin E could protect rat blood lymphocytes from lipid peroxidation caused by iron ions and a 7 mT static magnetic field in vitro. Simultaneous exposure to the 7 mT static magnetic field and iron ions produced a significant increase in lipid peroxidation end-products compared with control samples and those exposed to the field alone. When cells were pre-treated with melatonin or vitamin E before that same exposure, lipid peroxidation was significantly reduced, and melatonin was less effective than vitamin E under these conditions.

Why This Matters

Lipid peroxidation was chosen specifically as a marker of free radical activity produced by the static magnetic field. Cells were supplemented with 0.5 mM melatonin or 0.1 mM vitamin E during preincubation before exposure. During exposure, some samples were treated with ferrous chloride at 10 mg/ml or 20 mg/ml, while the rest served as controls. The significant increase in lipid peroxidation end-products appeared only with simultaneous exposure to both the field and iron ions, not with the field alone.

Exposure Details

Magnetic Field
7 mT
Exposure Duration
3 h

Exposure Context

This study used 7 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 7 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 35 times the FCC limit

Study Details

The purpose of this study was to examine the effect of melatonin and vitamin E (trolox) on the level of lipid peroxidation in rat blood lymphocytes after in vitro (3 h) exposure to iron ions and/or 7mT static magnetic field (SMF).

The lipid peroxidation process was chosen as a marker of free radical mechanism of SMF in cells. The...

There is a significant increase in the amount of lipid peroxidation end-products (4-HNE + MDA) in ra...

Cite This Study
Jajte J, Zmyślony M, Rajkowska E. (2003). Protective effect of melatonin and vitamin E against prooxidative action of iron ions and static magnetic field Med Pr. 54(1):23-28, 2003.
Show BibTeX
@article{j_2003_protective_effect_of_melatonin_390,
  author = {Jajte J and Zmyślony M and Rajkowska E.},
  title = {Protective effect of melatonin and vitamin E against prooxidative action of iron ions and static magnetic field},
  year = {2003},
  
  url = {https://europepmc.org/article/med/12731401},
}
PubMed: 12731401

Cited By (8 papers)

Quick Questions About This Study

The study used a 7 mT static magnetic field, with cells exposed in Helmholtz coils.
The significant increase in lipid peroxidation end-products occurred with simultaneous exposure to the 7 mT static magnetic field and iron ions, not with the field alone.
Vitamin E (trolox) was more effective than melatonin at inhibiting lipid peroxidation under the experimental conditions used.
The researchers studied rat blood lymphocytes exposed in vitro for 3 hours.
The researchers measured 4-HNE and MDA as the lipid peroxidation end-products.