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Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.

Cellular Effects

Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells.

No Effects Found

Miyakoshi J, Takemasa K, Takashima Y, Ding GR, Hirose H, Koyama S · 2005

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RF radiation at cell phone-level exposures disrupted cellular protection mechanisms without triggering obvious stress responses in brain cells.

Plain English Summary

Summary written for general audiences

Researchers exposed human brain tumor cells to 1950 MHz radiofrequency radiation (similar to 3G cell phone frequencies) at various intensities for up to 2 hours. While the radiation didn't affect cell growth or activate major stress response proteins, it did reduce a specific cellular protection mechanism at the highest exposure level (10 W/kg). This suggests that even when cells appear unaffected, subtle molecular changes may still be occurring.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.95 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.95 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

The study examined exposure from: 1950 MHz Duration: 2h

Study Details

To study the effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells.

Human glioma MO54 cells were used to investigate whether radio frequency (RF) field exposure could a...

It was found that sham exposed and RF exposed cells demonstrated a similar growth pattern up to 4 d...

Our results suggest that although exposure to a 1950 MHz RF field has no effect on cell proliferation and expression of Hsp 27 and Hsp70, it may inhibit the phosphorylation of Hsp27 at Serine 78 in MO54 cells.

Cite This Study
Miyakoshi J, Takemasa K, Takashima Y, Ding GR, Hirose H, Koyama S (2005). Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells. Bioelectromagnetics. 26(4):251-257, 2005.
Show BibTeX
@article{j_2005_effects_of_exposure_to_3249,
  author = {Miyakoshi J and Takemasa K and Takashima Y and Ding GR and Hirose H and Koyama S},
  title = {Effects of exposure to a 1950 MHz radio frequency field on expression of Hsp70 and Hsp27 in human glioma cells.},
  year = {2005},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/15832340/},
}
PubMed: 15832340

Cited By (71 papers)

View all 71 citing papers on Semantic Scholar

Quick Questions About This Study

A 2005 study found that 1950 MHz radiofrequency radiation (similar to 3G frequencies) did not affect the growth of human brain tumor cells over 4 days. Cells exposed to radiation showed similar growth patterns to unexposed cells, even at high exposure levels of 10 W/kg.
Research on 1950 MHz radiation showed no activation of major heat shock proteins Hsp27 and Hsp70 in human brain tumor cells. These proteins typically activate during cellular stress, suggesting the radiation didn't trigger significant stress responses at the tested exposure levels.
High-level 1950 MHz exposure at 10 W/kg significantly reduced phosphorylated Hsp27 levels in brain tumor cells. This molecular change occurred without affecting overall cell growth or stress protein expression, indicating subtle cellular effects even when cells appear normal.
A study exposing human brain tumor cells to 1950 MHz radiation for up to 2 hours found no effects on cell survival or growth. However, the highest exposure level (10 W/kg) did alter specific cellular protection mechanisms, suggesting potential molecular changes.
Research found that 1950 MHz radiation exposure didn't activate typical cellular stress indicators like Hsp70 and Hsp27 proteins in human glioma cells. However, it did reduce a specific cellular protection mechanism at high exposure levels, indicating subtle molecular effects.