Note: This study found no significant biological effects under its experimental conditions. We include all studies for scientific completeness.
Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells.
Park J, Kwon JH, Kim N, Song K · 2017
View Original AbstractShort-term exposure to 1950 MHz RF-EMF did not significantly alter APP, BACE1 protein or secreted Aβ peptide in neural cells.
Plain English Summary
Researchers exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to 1950 MHz RF-EMF at a SAR of 6 W/kg for 2 hours per day over 3 days. They analyzed mRNA and protein expression of key genes involved in Aβ processing. In HT22 cells, mRNA levels of APP, BACE1, ADAM10 and PSEN1 decreased, while APP mRNA was unchanged in SH-SY5Y cells. Protein expression of APP and BACE1 and secreted Aβ peptide did not differ significantly between exposed and control cells.
Why This Matters
The study was designed to test whether 1950 MHz RF-EMF influences Aβ processing in neural cells. The authors noted that the short-term exposure may not have a significant physiological effect on Aβ processing.
Exposure Details
- SAR
- 6 W/kg
- Source/Device
- 1950 MHz
- Exposure Duration
- 2 h per day for 3 days
Exposure Context
This study used 6 W/kg for SAR (device absorption):
- 15x above the Building Biology guideline of 0.4 W/kg
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In this study, we examined whether exposure to 1950 MHz RF-EMF affects Aβ processing in neural cells.
We exposed HT22 mouse hippocampal neuronal cells and SH-SY5Y human neuroblastoma cells to RF-EMF (SA...
When exposed to RF-EMF, mRNA levels of APP, BACE1, ADAM10 and PSEN1 were decreased in HT22, but the ...
These observations suggest that RF-EMF exposure may not have a significant physiological effect on Aβ processing of neural cells in the short term. However, considering that we only exposed HT22 and SH-SY5Y cells to RF-EMF for 2 h per day for 3 days, we cannot exclude the possibility that 1950 MHz RF-EMF induces physiological change in Aβ processing with long-term and continuous exposure.
Show BibTeX
@article{j_2017_effects_of_1950_mhz_3297,
author = {Park J and Kwon JH and Kim N and Song K},
title = {Effects of 1950 MHz radiofrequency electromagnetic fields on Aβ processing in human neuroblastoma and mouse hippocampal neuronal cells.},
year = {2017},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778507/},
}