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Brain & Nervous System

1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice.

No Effects Found

Son Y, Jeong YJ, Kwon JH, Choi HD, Pack JK, Kim N, Lee YS, Lee HJ · 2016

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Three-month RF-EMF exposure did not affect Aβ-related memory impairment or Aβ accumulation in 5xFAD mice.

Plain English Summary

Summary written for general audiences

Researchers exposed 5xFAD mice to 1950 MHz RF-EMF at 5 W/kg SAR for 2 hours daily, 5 days a week, for 3 months. They used Y-maze, Morris water maze, and novel object recognition tests to assess spatial and non-spatial memory. They also measured Aβ deposition, APP and CTFβ levels in hippocampus and cortex, and plasma Aβ peptides. The 3-month exposure did not affect Aβ-related memory impairment or Aβ accumulation.

Why This Matters

The study aimed to test whether RF-EMFs induce molecular changes in APP processing and Aβ-related memory impairment in the 5xFAD mouse model. Mice were 1.5 months old at start and divided into RF-EMF and sham groups with eight mice each.

Exposure Details

SAR
5 W/kg
Source/Device
1950 MHz
Exposure Duration
2 h/day, 5 days/week for 3 months

Exposure Context

This study used 5 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 5 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 3 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 1.95 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 1.95 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

The increased use of mobile phones has generated public concern about the impact of radiofrequency electromagnetic fields (RF-EMF) on health. In the present study, we investigated whether RF-EMFs induce molecular changes in amyloid precursor protein (APP) processing and amyloid beta (Aβ)-related memory impairment in the 5xFAD mouse, which is a widely used amyloid animal model.

The 5xFAD mice at the age of 1.5 months were assigned to two groups (RF-EMF- and sham-exposed groups...

These findings indicate that 3-month RF-EMF exposure did not affect Aβ-related memory impairment or Aβ accumulation in the 5xFAD Alzheimer's disease model.

Cite This Study
Son Y, Jeong YJ, Kwon JH, Choi HD, Pack JK, Kim N, Lee YS, Lee HJ (2016). 1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice. Bioelectromagnetics. 37(6):391-399, 2016.
Show BibTeX
@article{y_2016_1950_mhz_radiofrequency_electromagnetic_3413,
  author = {Son Y and Jeong YJ and Kwon JH and Choi HD and Pack JK and Kim N and Lee YS and Lee HJ},
  title = {1950 MHz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice.},
  year = {2016},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/27434853/},
}
PubMed: 27434853

Cited By (35 papers)

Quick Questions About This Study

Mice were exposed to 1950 MHz fields at 5 W/kg SAR for 2 hours daily, 5 days a week, for 3 months.
The Y-maze, Morris water maze, and novel object recognition memory test were used to evaluate spatial and non-spatial memory.
Aβ deposition and APP and CTFβ levels were evaluated in the hippocampus and cortex, and plasma Aβ peptides were also investigated.
The 3-month RF-EMF exposure did not affect Aβ-related memory impairment or Aβ accumulation in the 5xFAD Alzheimer's disease model.