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Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.

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Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Djordjević DM, Ćirković S, Brkić P, Todorović J · 2018

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Chronic exposure to 1 mT static magnetic fields altered brain enzyme activity and increased oxidative stress in rats.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to static magnetic fields for 50 days and found significant changes in brain enzyme activity, including increased levels of enzymes that control nerve signaling and cellular energy. The magnetic field exposure also increased oxidative stress markers and decreased protective antioxidant activity in brain tissue. These findings suggest that chronic magnetic field exposure can alter fundamental brain chemistry in ways that might affect neurological health.

Why This Matters

This study demonstrates that even relatively weak static magnetic fields (1 milliTesla) can produce measurable biological effects in brain tissue after chronic exposure. To put this in perspective, 1 mT is about 20 times stronger than Earth's magnetic field but still within the range of some industrial and medical environments. What makes this research particularly significant is that it examined fundamental brain enzymes involved in nerve signaling and cellular energy production - changes that could potentially impact neurological function. The researchers found increased oxidative stress alongside these enzyme changes, suggesting the brain was experiencing biological stress from the magnetic field exposure. While the authors note potential therapeutic applications, the reality is that any biological effect powerful enough to be therapeutic is also powerful enough to be harmful under different circumstances. This adds to the growing body of evidence that magnetic fields, even static ones, are not biologically neutral as often assumed.

Exposure Details

Magnetic Field
1 mG

Exposure Context

This study used 1 mG for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 mGExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Severe Concern rangeFCC limit is 2,000x higher than this level

Study Details

It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF.

Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up ...

Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (...

It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance

Cite This Study
Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Djordjević DM, Ćirković S, Brkić P, Todorović J (2018). Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. Int J Radiat Biol. 94(11):1062-1071, 2018.
Show BibTeX
@article{m_2018_modulation_of_rat_synaptosomal_346,
  author = {Dinčić M and Krstić DZ and Čolović MB and Nešović Ostojić J and Kovačević S and De Luka SR and Djordjević DM and Ćirković S and Brkić P and Todorović J},
  title = {Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.},
  year = {2018},
  doi = {10.1080/09553002.2018.1518611},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2018.1518611},
}
DOI: 10.1080/09553002.2018.1518611

Cited By (11 papers)

Quick Questions About This Study

Research shows magnetic fields can alter brain chemistry. A 2018 study found that 50 days of magnetic field exposure significantly changed enzyme activity in rat brain tissue, affecting systems that control nerve signaling and cellular energy production.
Magnetic field exposure can disrupt brain chemistry without necessarily causing permanent damage. Studies show chronic exposure increases oxidative stress and decreases protective antioxidant activity in brain tissue, which may affect neurological health over time.
Static magnetic field exposure appears to alter fundamental brain processes. Research demonstrates that chronic exposure increases certain brain enzymes and oxidative stress markers while reducing protective antioxidants, suggesting potential impacts on neurological function.
Magnetic fields can significantly alter nerve-related enzyme activity in the brain. Studies show chronic exposure increases acetylcholinesterase, an enzyme crucial for nerve signaling, which researchers note may have implications for various neurological conditions.
Magnetic field exposure may increase neurological risks by disrupting brain chemistry. Research shows chronic exposure alters enzymes involved in nerve signaling and energy production, processes that play important roles in the development of neurological diseases.