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Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.

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Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Djordjević DM, Ćirković S, Brkić P, Todorović J · 2018

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Chronic exposure to a 1 mT static magnetic field significantly increased ATPase and acetylcholinesterase activities in rat brain synaptosomes.

Plain English Summary

Summary written for general audiences

Researchers exposed Wistar albino rats to upward- or downward-oriented static magnetic fields for 50 days, then measured enzyme activities and oxidative stress markers in synaptosomes isolated from the whole rat brain. Chronic exposure to 1 mT static magnetic field significantly increased ATPase and acetylcholinesterase activities, and raised malondialdehyde levels in both exposed groups compared to controls. Synaptosomal catalase activity was significantly decreased in the group exposed to the downward-oriented field compared to both the control group and the upward-oriented field group.

Why This Matters

The researchers noted that the mechanism of static magnetic field influence on living organisms is not well understood. Each experimental group contained six animals, and the field orientations tested were upward and downward directed. The study followed modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses in synaptosomes isolated from rats. The researchers suggested that static magnetic field influence on the activity of these enzymes may have potential therapeutic importance.

Exposure Details

Magnetic Field
1 mT

Exposure Context

This study used 1 mT for magnetic fields:

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Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 5 times the FCC limit

Study Details

It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF.

Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up ...

Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (...

It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance

Cite This Study
Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Djordjević DM, Ćirković S, Brkić P, Todorović J (2018). Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field. Int J Radiat Biol. 94(11):1062-1071, 2018.
Show BibTeX
@article{m_2018_modulation_of_rat_synaptosomal_346,
  author = {Dinčić M and Krstić DZ and Čolović MB and Nešović Ostojić J and Kovačević S and De Luka SR and Djordjević DM and Ćirković S and Brkić P and Todorović J},
  title = {Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.},
  year = {2018},
  doi = {10.1080/09553002.2018.1518611},
  url = {https://www.tandfonline.com/doi/abs/10.1080/09553002.2018.1518611},
}
DOI: 10.1080/09553002.2018.1518611

Cited By (11 papers)

Quick Questions About This Study

The study used static magnetic fields oriented either upward or downward at an intensity of 1 mT.
The rats were exposed for 50 days before being sacrificed and having their brain tissue analyzed.
Catalase activity was significantly lower in the downward-field group (1.48 ± 0.17 U/mg protein) than in the control group (2.60 ± 0.29 U/mg protein) or the upward-field group (2.72 ± 0.21 U/mg protein).
Malondialdehyde levels were measured as an oxidative stress marker, and they increased in both exposed groups compared to control values.
The researchers concluded that chronic exposure to differently oriented static magnetic fields increases ATPase and acetylcholinesterase activities in rat synaptosomes.