Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.
Dinčić M, Krstić DZ, Čolović MB, Nešović Ostojić J, Kovačević S, De Luka SR, Djordjević DM, Ćirković S, Brkić P, Todorović J. · 2018
View Original AbstractStatic magnetic fields at 1 mT altered brain enzyme activity and increased oxidative stress in rats after 50 days of exposure.
Plain English Summary
Researchers exposed rats to weak static magnetic fields (1 mT) for 50 days and examined brain enzyme activity. They found that magnetic field exposure significantly increased the activity of key brain enzymes involved in nerve communication and energy metabolism, while also causing oxidative stress damage. These enzymes play important roles in neurological diseases, suggesting that even weak magnetic fields can alter brain chemistry.
Why This Matters
This study demonstrates that prolonged exposure to relatively weak static magnetic fields can measurably alter brain biochemistry in ways that could affect neurological function. The 1 mT exposure level is comparable to what you might encounter from some magnetic therapy devices or industrial equipment, though much stronger than typical household sources. What's particularly noteworthy is that the researchers observed these changes after 50 days of exposure, suggesting cumulative effects rather than immediate responses. The increased enzyme activity combined with oxidative stress markers indicates the brain is working harder to maintain normal function under magnetic field exposure. While the researchers suggest potential therapeutic applications, the oxidative stress component raises questions about whether these biochemical changes represent adaptation or early signs of cellular stress.
Exposure Details
- Magnetic Field
- 1 mG
- Exposure Duration
- 50 days
Exposure Context
This study used 1 mG for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF.
Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up ...
Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (...
It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance.
Show BibTeX
@article{m_2018_modulation_of_rat_synaptosomal_635,
author = {Dinčić M and Krstić DZ and Čolović MB and Nešović Ostojić J and Kovačević S and De Luka SR and Djordjević DM and Ćirković S and Brkić P and Todorović J.},
title = {Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field.},
year = {2018},
url = {https://pubmed.ncbi.nlm.nih.gov/30238840/},
}