Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure
Esmekaya MA, Tuysuz MZ, Tomruk A, Canseven AG, Yücel E, Aktuna Z, Keskil S, Seyhan N. · 2016
View Original AbstractIn mice with induced epileptic seizures, cell phone radiation was associated with increased oxidative damage and nitric oxide levels in brain tissue.
Plain English Summary
Researchers studied whether cellular phone radiation affects oxidative stress and nitric oxide levels in mouse brain during epileptic seizures induced by pentylenetetrazole (PTZ). Eight-week-old mice were divided into groups: a PTZ-only control group, a group exposed to 15 minutes of radiation before and 30 minutes after PTZ treatment, and a group exposed to 30 minutes of radiation before and 30 minutes after PTZ treatment. Lipid peroxidation and nitric oxide levels increased significantly in the radiation-exposed groups compared to the control group, while glutathione levels were significantly lower in those same groups.
Why This Matters
The RF radiation used in the study was produced by a 900 MHz cellular phone. Oxidative stress was measured by quantifying thiobarbituric acid reactive substances (TBARS), a marker of lipid peroxidation. Glutathione levels were determined by the Ellman method and nitric oxide levels were obtained using the Griess assay. No statistically significant alterations in any of the endpoints were noted between group II and group III. The researchers concluded that cellular phone radiation may increase oxidative damage and nitric oxide levels during epileptic activity in the mouse brain.
Exposure Details
- SAR
- 0.301, 0.367 W/kg
- Electric Field
- 14.31 V/m
- Source/Device
- 900 MHz
- Exposure Duration
- Group I - (15 min cellular phone radiation + PTZ treatment + 30 min cellular phone radiation) AND Group II (30 min cellular phone radiation + PTZ treatment + 30 min cellular phone radiation)
Exposure Context
This study used 14.31 V/m for electric fields:
- 47.7x above the Building Biology guideline of 0.3 V/m
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The objective of the this study was to evaluate the effects of cellular phone radiation on oxidative stress parameters and oxide levels in mouse brain during pentylenetetrazole (PTZ) induced epileptic seizure.
Eight weeks old mice were used in the study. Animals were distributed in the following groups: Group...
Lipid peroxidation and NOx levels of brain tissue increased significantly in group II and III compar...
The experimental findings demonstrated that cellular phone radiation may increase the oxidative damage and NOx level during epileptic activity in mouse brain.
Show BibTeX
@article{ma_2016_effects_of_cell_phone_525,
author = {Esmekaya MA and Tuysuz MZ and Tomruk A and Canseven AG and Yücel E and Aktuna Z and Keskil S and Seyhan N.},
title = {Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure},
year = {2016},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0891061816300084},
}