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Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland.

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Misa Agustiño MJ, Leiro JM, Jorge Mora MT, Rodríguez-González JA, Jorge Barreiro FJ, Ares-Pena FJ, López-Martín E · 2012

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WiFi-frequency radiation triggered cellular stress in thyroid glands at non-heating levels, challenging safety assumptions about wireless devices.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to WiFi-frequency radiation (2.45 GHz) for 30 minutes and found it triggered cellular stress responses in thyroid tissue. Heat shock proteins dropped significantly within 90 minutes, though recovered by 24 hours, demonstrating that brief microwave exposure can disrupt normal thyroid cell function.

Why This Matters

This study adds to growing evidence that microwave radiation affects cellular function at power levels far below what regulators consider safe. The 2.45 GHz frequency tested is identical to what your WiFi router and microwave oven use, and the exposure levels (0.046-0.104 W/kg) are well within ranges you might encounter from wireless devices. What makes this research particularly significant is that it demonstrates measurable biological effects without any heating - contradicting the long-held assumption that non-thermal EMF exposure is harmless. The thyroid's vulnerability is especially concerning given its critical role in metabolism and hormone regulation. While the stress protein levels recovered in this acute study, we don't know what repeated daily exposures might do over months or years.

Exposure Details

SAR
0.046±1.10 , 0.104±0.00510 W/kg
Source/Device
2.45 GHz
Exposure Duration
30 min

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.046±1.10 , 0.104±0.00510 W/kgExtreme Concern0.1 W/kgFCC Limit1.6 W/kgEffects observed in the Severe Concern range (Building Biology)FCC limit is 35x higher than this exposure level

Study Details

To study whether electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland

Using the enzyme-linked immunosorbent assay (ELISA) technique, we studied levels of HSP-90 and HSP-7...

Ninety minutes after radiation, HSP-90 and HSP-70 had decreased significantly (P<0.01) after applyin...

The results suggest that acute sub-thermal radiation at 2.45 GHz may alter levels of cellular stress in rat thyroid gland without initially altering their anti-apoptotic capacity.

Cite This Study
Misa Agustiño MJ, Leiro JM, Jorge Mora MT, Rodríguez-González JA, Jorge Barreiro FJ, Ares-Pena FJ, López-Martín E (2012). Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland. Biol Open. 1(9):831-838, 2012.
Show BibTeX
@article{mj_2012_electromagnetic_fields_at_245_1206,
  author = {Misa Agustiño MJ and Leiro JM and Jorge Mora MT and Rodríguez-González JA and Jorge Barreiro FJ and Ares-Pena FJ and López-Martín E},
  title = {Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland.},
  year = {2012},
  
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507243/},
}

Quick Questions About This Study

Researchers exposed rats to WiFi-frequency radiation (2.45 GHz) for 30 minutes and found it triggered cellular stress responses in thyroid tissue. Heat shock proteins dropped significantly within 90 minutes, though recovered by 24 hours, demonstrating that brief microwave exposure can disrupt normal thyroid cell function.