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A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells. Int J Radiat Biol. 88(3):239-244, 2012.

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Sun W, Shen X, Lu D, Fu Y, Lu D, Chiang H · 2012

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Cell phone radiation activated cellular growth receptors in just 15 minutes at levels comparable to typical phone use.

Plain English Summary

Summary written for general audiences

Cell phone radiation (1.8 GHz) activated growth receptors in human cells after just 15 minutes of exposure. The effects occurred at radiation levels of 0.5 W/kg and higher but not at 0.1 W/kg, showing radiofrequency radiation can directly trigger cellular responses that control cell growth and communication.

Why This Matters

This study provides important evidence that radiofrequency radiation can directly interact with cellular membrane receptors at relatively low exposure levels. The researchers identified a clear threshold effect between 0.1 and 0.5 W/kg SAR, which is significant because many cell phones operate in the 1-2 W/kg range during calls. The activation of EGF receptors is particularly concerning because these receptors control cell growth, division, and survival processes that, when disrupted, can contribute to various health problems including cancer development. What makes this research especially valuable is that it demonstrates a clear dose-response relationship and identifies a specific biological mechanism by which RF radiation affects cells. The science demonstrates that even brief exposures can trigger cellular responses, challenging the assumption that only heating effects matter. This adds to the growing body of evidence showing that our current safety standards, which focus solely on preventing tissue heating, may not adequately protect against biological effects occurring at much lower exposure levels.

Exposure Details

SAR
0.5, 1.0, 2.0, or 4.0, 0.1 W/kg
Source/Device
1.8-GHz
Exposure Duration
15 min

Where This Falls on the Concern Scale

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in ContextThis study: 0.5, 1.0, 2.0, or 4.0, 0.1 W/kgExtreme Concern0.1 W/kgFCC Limit1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)FCC limit is 16x higher than this exposure level

Study Details

Many studies have shown that exposure to radiofrequency radiation (RFR) could activate cellular signal transduction pathways. In the present research, we investigated the effects of exposure to a 1.8-GHz RFR at different intensities on epidermal growth factor (EGF) receptor clustering and phosphorylation in human amniotic (FL) cells.

Receptor clustering on cellular membrane surface was analyzed using immunofluorescence assessed by c...

The results showed that, compared with sham exposure, exposure to RFR at specific absorption rate (S...

Based on the results of this experiment, we conclude that membrane receptors could be one of the main targets that RFR interacts with cells, and the dose-rate threshold, in the case of EGF receptors, is between SAR of 0.1 and 0.5 W/kg. The results indicate a sigmoid dependence of RFR effects on intensity.

Cite This Study
Sun W, Shen X, Lu D, Fu Y, Lu D, Chiang H (2012). A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells. Int J Radiat Biol. 88(3):239-244, 2012. Int J Radiat Biol. 88(3):239-244, 2012.
Show BibTeX
@article{w_2012_a_18ghz_radiofrequency_radiation_1345,
  author = {Sun W and Shen X and Lu D and Fu Y and Lu D and Chiang H},
  title = {A 1.8-GHz radiofrequency radiation induces EGF receptor clustering and phosphorylation in cultured human amniotic (FL) cells. Int J Radiat Biol. 88(3):239-244, 2012. },
  year = {2012},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/22032630/},
}

Quick Questions About This Study

Cell phone radiation (1.8 GHz) activated growth receptors in human cells after just 15 minutes of exposure. The effects occurred at radiation levels of 0.5 W/kg and higher but not at 0.1 W/kg, showing radiofrequency radiation can directly trigger cellular responses that control cell growth and communication.