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Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain

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Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taşkin A · 2010

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Long-term ELF magnetic field exposure did not change apoptosis in rat brain, but both 100 and 500 µT exposures induced oxidative stress and diminished antioxidant defense.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to extremely low-frequency magnetic fields for 2 hours per day for 10 months, then measured apoptosis and oxidative stress markers in brain tissue. Apoptosis scores and MPO activity were not significantly different between the exposed and sham groups. MDA, TOS, and OSI values were found to be higher in the ELF-500 group than in the ELF-100 and sham groups, and total antioxidative capacity was lower in the ELF-500 group.

Why This Matters

The two exposure levels tested correspond to public and occupational safety standards. Apoptosis was assessed by immunohistochemical staining for active caspase-3 in brain tissue using a semi-quantitative scoring system. Catalase activity decreased in both exposure groups. The researchers concluded that both 100 and 500 µT ELF-MF exposures induced a toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense.

Exposure Details

Magnetic Field
0.1, 0.5 mT
Source/Device
50 Hz
Exposure Duration
2 hr/day for 10 months

Exposure Context

This study used 0.1, 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1, 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

This study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat.

Rats were exposed to 100 and 500 µT ELF-MF, which are the safety standards of public and occupationa...

Final score of apoptosis and MPO activity were not significantly different between the groups. CAT a...

In conclusion, apoptosis was not changed by long-term ELF-MF exposure, while both 100 and 500 µT ELF-MF exposure induced toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense

Cite This Study
Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taşkin A (2010). Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain Biol Trace Elem Res. 138(1-3):238-249, 2010.
Show BibTeX
@article{mz_2010_effects_of_extremely_lowfrequency_215,
  author = {Akdag MZ and Dasdag S and Ulukaya E and Uzunlar AK and Kurt MA and Taşkin A},
  title = {Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain},
  year = {2010},
  doi = {10.1007/s12011-010-8615-3},
  url = {https://link.springer.com/article/10.1007/s12011-010-8615-3},
}
DOI: 10.1007/s12011-010-8615-3

Cited By (71 papers)

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Quick Questions About This Study

Apoptosis scores were not significantly different between groups, and the researchers concluded that apoptosis was not changed by long-term ELF-MF exposure.
Rats were exposed to 100 and 500 µT ELF magnetic fields for 2 hours per day for 10 months.
MDA, TOS, and OSI values were found to be higher in the ELF-500 group than in the ELF-100 and sham groups, and total antioxidative capacity was lower in the ELF-500 group.
Catalase activity decreased in both exposure groups.
The researchers concluded that both 100 and 500 µT ELF-MF exposure induced a toxic effect in the rat brain by increasing oxidative stress and diminishing antioxidant defense.