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Do 100- and 500-μT ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains?

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Akdag MZ, Dasdag S, Cakir DU, Yokus B, Kizil G, Kizil M. · 2013

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Exposure to 100- and 500-μT ELF magnetic fields increased protein carbonyl and malondialdehyde levels in rat brains, but did not significantly alter beta-amyloid protein.

Plain English Summary

Summary written for general audiences

Researchers exposed adult male Sprague-Dawley rats to 50 Hz ELF magnetic fields at 100 or 500 μT for 2 hours per day for 10 months, then measured beta-amyloid protein, protein carbonyl, and malondialdehyde in the brain. Protein carbonyl and malondialdehyde levels were increased by exposure to both field strengths, while beta-amyloid protein levels were not significantly changed.

Why This Matters

Thirty adult male Sprague-Dawley rats were divided into two experimental groups and a sham-exposed group. The sham group went through the same procedures but with the generator turned off. The researchers noted that the field strengths used are generally accepted safety standards for public and occupational exposures. Both protein carbonyl and malondialdehyde levels were altered by long-term exposure to either field strength, according to the study's conclusion. The authors stated that many further and more comprehensive studies will be required to understand the interaction mechanisms between ELF-MF exposure and living organisms.

Exposure Details

Magnetic Field
0.1, 0.5 mT
Source/Device
50 Hz
Exposure Duration
2 h/day for 10 months

Exposure Context

This study used 0.1, 0.5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.1, 0.5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)FCC limit is 2 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

the aim of this study was to illuminate the interaction between biomolecules and ELF-MFs by investigating the effect of ELF-MFs on beta-amyloid protein (BAP), protein carbonyl (PC) and malondialdehyde (MDA) in rat brain.

For this study, 30 adult male Sprague-Dawley rats were used, which were divided into two experimenta...

The results of this study showed that neither ELF-MFs used in this study altered BAP level significa...

In conclusion, both PC and MDA levels were altered by long-term exposure to either 100 or 500 μT ELF-MF. However, many further and more comprehensive studies will be required to elucidate the interaction mechanisms between ELF-MFs exposure and living organisms.

Cite This Study
Akdag MZ, Dasdag S, Cakir DU, Yokus B, Kizil G, Kizil M. (2013). Do 100- and 500-μT ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains? Electromagn Biol Med. 32(3):363-372, 2013.
Show BibTeX
@article{mz_2013_do_100_and_500t_216,
  author = {Akdag MZ and Dasdag S and Cakir DU and Yokus B and Kizil G and Kizil M.},
  title = {Do 100- and 500-μT ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains? },
  year = {2013},
  doi = {10.3109/15368378.2012.721848},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2012.721848},
}
DOI: 10.3109/15368378.2012.721848

Cited By (23 papers)

Quick Questions About This Study

Rats were exposed to 50 Hz ELF magnetic fields at strengths of 100 or 500 μT for 2 hours per day for 10 months.
Neither field strength significantly altered beta-amyloid protein levels in rat brain (p>0.05).
Protein carbonyl and malondialdehyde levels were increased by exposure to 100- and 500-μT ELF magnetic fields (p < 0.0001).
The same procedures were applied to the sham group rats, but with the generator turned off.
The authors concluded that many further and more comprehensive studies will be required to elucidate the interaction mechanisms between ELF-MF exposure and living organisms.