6,486 Studies Reviewed. 85.2% of Original Studies Found Biological Effects. The Evidence is Clear.
Shield Your Body
Reproductive Health

Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice.

Bioeffects Seen

Pandey N, Giri S, Das S, Upadhaya P. · 2017

View Original Abstract
Share:

RFR exposure caused DNA damage and altered cell cycle progression in germ cells, leading to low sperm count in mice, but the changes showed recovery after a post-exposure period.

Plain English Summary

Summary written for general audiences

Swiss albino mice were exposed to 900 MHz RFR for 4 hours and 8 hours per day for 35 days, with one group terminated after exposure and another kept for an additional 35 days post-exposure. RFR exposure caused mitochondrial membrane depolarization and redox imbalance, along with statistically significant increases in DNA damage index and sperm head defects. Flow cytometry showed a 2.5-fold increase in spermatogonia and decreased spermatids, with reduced turnover ratios indicating premeiotic arrest and low sperm count. Histological alterations included sloughing of immature germ cells, epithelium depletion, and maturation arrest, but all changes showed recovery to varied degrees after the post-exposure period.

Why This Matters

The study was designed to evaluate alterations in male germ cell transformation kinetics following RFR exposure and after a recovery period. The researchers concluded that RFR-induced oxidative stress causes DNA damage in germ cells, which alters cell cycle progression and leads to low sperm count in mice.

Exposure Information

A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Specific exposure levels were not quantified in this study. The study examined exposure from: 900 MHz Duration: 4 h and 8 h duration per day for 35 days

Study Details

This study evaluates alterations in male germ cell transformation kinetics following RFR exposure and after recovery.

Swiss albino mice were exposed to RFR (900 MHz) for 4 h and 8 h duration per day for 35 days. One gr...

RFR exposure caused depolarization of mitochondrial membranes resulting in destabilized cellular red...

To conclude, RFR exposure-induced oxidative stress causes DNA damage in germ cells, which alters cell cycle progression leading to low sperm count in mice.

Cite This Study
Pandey N, Giri S, Das S, Upadhaya P. (2017). Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice. Toxicol Ind Health. 33(4):373-384, 2017.
Show BibTeX
@article{n_2017_radiofrequency_radiation_900_mhzinduced_1695,
  author = {Pandey N and Giri S and Das S and Upadhaya P.},
  title = {Radiofrequency radiation (900 MHz)-induced DNA damage and cell cycle arrest in testicular germ cells in swiss albino mice.},
  year = {2017},
  doi = {10.1177/0748233716671206},
  url = {https://journals.sagepub.com/doi/abs/10.1177/0748233716671206},
}
DOI: 10.1177/0748233716671206

Cited By (40 papers)

Quick Questions About This Study

Swiss albino mice were exposed to 900 MHz RFR for 4 hours and 8 hours per day for 35 days, with one group terminated after exposure and another kept for an additional 35 days post-exposure.
RFR exposure caused mitochondrial membrane depolarization and redox imbalance, along with statistically significant increases in DNA damage index and sperm head defects. Flow cytometry showed a 2.5-fold increase in spermatogonia and decreased spermatids, with reduced turnover ratios indicating premeiotic arrest and low sperm count.
All observed changes showed recovery to varied degrees following a 35-day post-exposure period, indicating the effects are detrimental but reversible.
Histological alterations included sloughing of immature germ cells into the seminiferous tubule lumen, epithelium depletion, and maturation arrest.