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Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent.

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Nylund R, Leszczynski D. · 2006

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Gene and protein expression were altered in both examined cell lines after one hour of mobile phone radiation exposure at 2.8 W/kg, but the same genes and proteins were differently affected in each line.

Plain English Summary

Summary written for general audiences

Researchers examined in vitro cell response to mobile phone radiation using two variants of a human endothelial cell line: EA.hy926 and EA.hy926v1. Gene expression changes were examined using cDNA Expression Arrays and protein expression changes were examined using 2-DE and PDQuest software. Gene and protein expression were altered in both examined cell lines after one hour of exposure at an average specific absorption rate of 2.8 W/kg, but the same genes and proteins were differently affected in each line.

Why This Matters

The researchers suggested that the cell response to mobile phone radiation might be genome- and proteome-dependent. They noted that different types of cells and cells from different species might respond differently to mobile phone radiation or might have different sensitivity to this weak stimulus. The authors proposed that their findings might also explain, at least in part, the origin of discrepancies in replication studies between different laboratories.

Exposure Details

SAR
2.8 W/kg
Source/Device
900 MHz GSM mobile
Exposure Duration
1h

Exposure Context

This study used 2.8 W/kg for SAR (device absorption):

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 2.8 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Extreme Concern range (Building Biology)This level is 2 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 900 MHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 900 MHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

To study the effects of Mobile phone radiation that causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome‐ and proteome‐dependent.

We have examined in vitro cell response to mobile phone radiation (900 MHz GSM signal) using two var...

Obtained results show that gene and protein expression were altered, in both examined cell lines, in...

Therefore, it is likely that different types of cells and from different species might respond differently to mobile phone radiation or might have different sensitivity to this weak stimulus. Our findings might also explain, at least in part, the origin of discrepancies in replication studies between different laboratories.

Cite This Study
Nylund R, Leszczynski D. (2006). Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent. Proteomics 6:4769-4780, 2006.
Show BibTeX
@article{r_2006_mobile_phone_radiation_causes_32,
  author = {Nylund R and Leszczynski D.},
  title = {Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent.},
  year = {2006},
  doi = {10.1002/pmic.200600076},
  url = {http://onlinelibrary.wiley.com/doi/10.1002/pmic.200600076/full},
}
DOI: 10.1002/pmic.200600076

Cited By (122 papers)

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Quick Questions About This Study

The study used two variants of a human endothelial cell line, EA.hy926 and EA.hy926v1, examined in vitro.
Cells were exposed to a 900 MHz GSM signal for one hour at an average specific absorption rate of 2.8 W/kg.
Although gene and protein expression were altered in both examined cell lines, the same genes and proteins were differently affected by the exposure in each of the cell lines.
The researchers suggested that the cell response to mobile phone radiation might be genome- and proteome-dependent.
The authors proposed their findings might explain, at least in part, the origin of discrepancies in replication studies between different laboratories.