Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod
Duan Y, Wang Z, Zhang H, He Y, Fan R, Cheng Y, Sun G, Sun X. · 2014
View Original AbstractExposure to a 50 Hz, 8 mT electromagnetic field for 28 days caused changes in glutamate signaling and reduced CREB phosphorylation in mice hippocampus, effects that were partially reversed by lotus seedpod procyanidins.
Plain English Summary
Researchers studied whether exposure to a 50 Hz, 8 mT extremely low frequency electromagnetic field for 28 days altered glutamate release in mice hippocampus and whether treatment with lotus seedpod procyanidins (LSPCs) could normalize those changes. Exposure increased glutamate, GABA, NMDA receptor 2B levels, and intracellular calcium concentration in the hippocampus, while decreasing ERK1/2 and CREB phosphorylation. Oral administration of LSPCs, especially at 60 and 90 mg per kilogram, markedly improved expressions of p-CREB, p-ERK1/2, and p-JNK1/2, and was accompanied by decreased levels of glutamate, GABA, intracellular calcium, and NR2B.
Why This Matters
Exposure increased JNK1/2 phosphorylation through activated ASK1, which the researchers noted plays a pivotal role in hippocampal neuronal cell death. The researchers suggested that calcium influx induced by the exposure stimulated activity of the ERK pathway, in turn influencing the expression of downstream proteins in that signaling pathway. The researchers suggested that normalization of p-ERK1/2, p-JNK1/2, intracellular calcium, and p-CREB expression, possibly via an NMDA receptor channel, might be responsible for the neuroprotective or memory-enhancing effects of LSPCs.
Exposure Details
- Magnetic Field
- 8 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 4 h/day for 28 days
Exposure Context
This study used 8 mT for magnetic fields:
- 400Kx above the Building Biology guideline of 0.2 mG
- 80Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In this study we determined whether the ELF-EMF (50 Hz, 8 mT, 28 days) exposure induced alterations of glutamate release in mice hippocampus and explored the possible mechanism, and if LSPC treatment normalized its alterations.
The results showed that ELF-EMF exposure induced the increased contents of glutamate, GABA, excessiv...
Thus, the results from the present study suggest that p-ERK1/2, p-JNK1/2, [Ca2+]i and p-CREB expression normalized, possibly via a NMDA receptor-channel through the changes of GABA, glutamate and NR2B, which might be responsible for the neuroprotective or memory enhancing effects of LSPCs.
Show BibTeX
@article{y_2014_extremely_low_frequency_electromagnetic_245,
author = {Duan Y and Wang Z and Zhang H and He Y and Fan R and Cheng Y and Sun G and Sun X.},
title = {Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod},
year = {2014},
url = {https://pubs.rsc.org/lv/content/articlelanding/2014/fo/c4fo00250d/unauth#!divAbstract},
}