Yan JG, Agresti M, Zhang LL, Yan Y, Matloub HS. · 2008
Researchers exposed adult Sprague-Dawley rats to cell phones for 6 hours per day for 126 days and measured mRNA levels of several injury-associated proteins in the brain. The proteins evaluated included Calcium ATPase, Neural Cell Adhesion Molecule, Neural Growth Factor, and Vascular Endothelial Growth Factor. The results showed statistically significant mRNA up-regulation of these proteins in the brains of exposed rats.
Sokolovic D et al. · 2008
Researchers exposed Wistar rats to microwave radiation from a mobile test phone for 20, 40, and 60 days to evaluate oxidative stress in brain tissue and whether melatonin could reduce it. Exposure led to a significant increase in malondialdehyde and carbonyl group concentrations in brain tissue, along with decreased catalase activity and increased xanthine oxidase activity. Melatonin treatment significantly prevented the rise in MDA content and xanthine oxidase activity after 40 days of exposure, but was unable to prevent the decrease in catalase activity or the increase in carbonyl group content.
Nittby H et al. · 2008
Researchers exposed rats to GSM-900 mobile phone radiation for 2 hours each week for 55 weeks at SAR levels of 0.6 and 60 mW/kg, then compared them to sham-exposed controls. GSM-exposed rats had impaired memory for objects and their temporal order of presentation compared to sham-exposed controls (P = 0.02). Detecting the place in which an object was presented was not affected by GSM exposure, and no difference in exploratory behaviour was seen in the open-field test.
Lee KS, Choi JS, Hong SY, Son TH, Yu K. · 2008
Researchers studied biological effects of mobile phone 835 MHz electromagnetic fields in Drosophila at SAR 1.6 W/kg and SAR 4.0 W/kg. At SAR 1.6 W/kg, more than 90% of flies remained viable even after the 30 h exposure, while at SAR 4.0 W/kg viability dropped from the 12 h exposure. Both exposure levels triggered a stress response, increased reactive oxygen species production, and activated ERK and JNK signaling, but not p38 kinase signaling. SAR 4.0 W/kg strongly activated JNK signaling, expression of apoptotic genes, and amplified the number of apoptotic cells in the fly brain.
Joubert, V., Bourthoumieu, S., Leveque, P. and Yardin, C. · 2008
Researchers exposed rat primary neuronal cultures to a continuous-wave 900 MHz radiofrequency field at a specific absorption rate of 2 W/kg for 24 hours. A statistically significant difference in the rate of apoptosis was found in the RF-field-exposed neurons compared to the sham-, 37°C- and 39°C-exposed neurons either 0 or 24 h after exposure using both methods. The percentage of AIF-positive nuclei in RF-field-exposed neurons was increased by three- to sevenfold compared to other conditions, while no increase in caspase 3 activity was found.
Eberhardt JL, Persson BR, Brun AE, Salford LG, Malmgren LO · 2008
Researchers exposed rats to GSM microwave signals in the 900 MHz band and measured blood-brain barrier permeability and signs of neuronal damage after recovery periods of 14 or 28 days. Non-anaesthetized rats were sham exposed or exposed to microwaves for 2 hours at whole-body specific absorption rates of 0.12, 1.2, 12, or 120 mW/kg. Albumin leakage and its uptake into neurons was enhanced after 14 days but not after the 28-day recovery period, while the occurrence of dark neurons was enhanced after 28 days.
Croft RJ et al. · 2008
Researchers tested 120 healthy participants in a double-blind, counterbalanced crossover design, with each person receiving a 30-minute active and a 30-minute sham exposure one week apart while EEG data were recorded. The purpose of the study was to test one of the strongest findings in the literature, that of increased alpha power in response to MP-type radiation. Overall alpha power was enhanced during exposure, with the effect larger at sites on the same side as the exposure source than on the opposite side over posterior regions. After exposure ended, no overall change to alpha power was observed, though there was less alpha power contralateral to the exposure source relative to the ipsilateral side.
Ammari M, Lecomte A, Sakly M, Abdelmelek H, de-Seze R · 2008
Researchers measured cytochrome oxidase levels in rat brains using histochemical methods to evaluate regional brain metabolic activity after GSM 900 MHz signal exposure. Rats were exposed either for 45 minutes per day at a SAR of 1.5 W/Kg or for 15 minutes per day at a SAR of 6 W/Kg, over seven days. At 6 W/Kg, decreased CO activity was found in areas of the prefrontal and frontal cortex, the hippocampus, and the posterior cortex, while exposure at 1.5 W/Kg did not affect brain activity.
Ammari M et al. · 2008
Researchers measured GFAP expression in rat brain areas using immunocytochemistry to evaluate glial changes 10 days after chronic exposure to a GSM 900 MHz signal. Rats were exposed 5 days a week for 24 weeks at a brain-averaged SAR of 1.5 W/kg for 45 minutes per day, or at 6 W/kg for 15 minutes per day. Compared with sham or cage control animals, rats exposed at 6 W/kg had increased GFAP stained surface areas (p < 0.05), while exposure at 1.5 W/kg did not increase GFAP expression. The researchers noted that chronic exposure at 6 W/kg may induce persistent astroglia activation in the rat brain, which they described as a sign of a potential gliosis.
Nittby H et al. · 2008
Researchers exposed Fischer 344 rats to radiation from a GSM mobile test phone at 1,800 MHz for 6 hours and then analyzed gene expression in the cortex and hippocampus. Four rats were exposed in an anechoic chamber one at a time, and four control rats were kept in the same chamber for the same duration without exposure. Gene ontology analysis found highly significant changes in gene categories related to membrane functions in both brain regions.
Unknown authors · 2007
Researchers tested 84 young healthy adults on two forced-choice tasks to detect a GSM mobile phone field at 902 MHz pulsed at 217 Hz. Participants completed 600 trials across three conditions per task with a monetary prize for 75% accuracy, but performance was no better than chance and no one won. Two participants scored 97% and 94% in one condition but failed to replicate the result in a retest one month later. Six participants who reported being able to perceive the field performed no better than others.
Shirai T et al. · 2007
Pregnant F344 rats received a single dose of ENU on gestational day 18. Rats were exposed to a 1.95-GHz W-CDMA signal for 90 minutes a day, 5 days a week, for 104 weeks starting at 5 weeks of age. Brain average specific absorption rates were designed to be .67 and 2.0 W/kg for low and high exposures, respectively. The incidence and numbers of brain tumors in female rats exposed to 1.95-GHz W-CDMA signals showed tendencies to increase but without statistical significance, and overall no significant increase in incidences or numbers was detected in either males or females.
Schmid G et al. · 2007
Researchers measured the dielectric properties of 20 freshly removed human pineal glands less than 20 hours after death. They developed a high-resolution numerical model of the brain region around the pineal gland based on a real human tissue sample. FDTD computations were performed for handheld device exposures close to the head at 400-1850 MHz. The highest absorption was at 400 MHz with 11 microW absorbed in a 96 mg gland from a 500 mW device. At 900 MHz and 1850 MHz, absorption was lower by factors of 4.2 and 36 respectively.
Parazzini M et al. · 2007
The GUARD project involved nine European centers and aimed to assess potential changes in auditory function from low-intensity EMFs produced by GSM cellular phones. Participants were healthy young adults without any evidence of hearing or ear disorders. Auditory function was assessed immediately before and after EMF exposure using hearing threshold level, transient otoacoustic emissions, distortion product otoacoustic emissions, and auditory brainstem response. The study used a double-blind design with genuine and sham exposures separated by at least 24 hours. Exposure consisted of speech at a typical conversational level delivered via an earphone to one ear, plus genuine or sham EMF exposure from a consumer cellular phone at full power for 10 min.
Masuda H et al. · 2007
Researchers exposed rat heads to 1439 MHz RF-EMF for 10 minutes at three intensity doses of 0.6, 2.4, and 4.8 W/kg BASAR. They measured blood-brain barrier permeability, leukocyte behavior, plasma velocity, and vessel diameter using a closed cranial window method. No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. Plasma velocities and vessel diameters remained constant within the physiological range throughout each exposure.
Masuda H et al. · 2007
Researchers exposed the heads of rats for four weeks (60 min/day, 5 days/week) to RF-EMF at 2.4 W/kg of brain averaged specific absorption rate (BASAR). They measured blood-brain barrier permeability, leukocyte behavior, and plasma velocity using a closed cranial window method. No extravasation of dyes from pial venules was found, no significant changes in endothelial-adhering leukocytes occurred, and plasma velocity remained constant within the physiological range. These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.
Kan P, Simonsen SE, Lyon JL, Kestle JR. · 2007
Researchers conducted a meta-analysis of nine case-control studies with 5,259 brain tumor cases and 12,074 controls to examine cellular phone use and brain tumor risk. The pooled analysis showed an overall odds ratio of 0.90 with a 95% confidence interval of 0.81 to 0.99 for cellular phone use and brain tumor development. For long-term users of ten years or more, the pooled odds ratio was 1.25 with a 95% confidence interval of 1.01 to 1.54 based on five studies. No increased risk was observed for analog or digital cellular phone users.
Glover PM, Eldeghaidy S, Mistry TR, Gowland PA. · 2007
Researchers used an MRI gradient coil to produce a time-varying magnetic field of 0.5 kHz and peak field of approximately 8.7 T/s in the human brain. Visual evoked potentials were recorded from occipital sites O1 and O2 in response to a checkerboard stimulus before, during, and after a 10-minute exposure period in seven subjects. No significant effects were found on the peak amplitude or latency of the VEP P100 responses at O1 and O2.
Joubert V, Leveque P, Cueille M, Bourthoumieu S, Yardin C. · 2007
Researchers exposed primary cultured neurons from embryonic Wistar rat cortices to a 900-MHz GSM field for 24 hours at 0.25 W/kg SAR. Apoptosis was measured immediately and 24 hours after exposure using DAPI staining, TUNEL/PI flow cytometry, and caspase-3 fluorimetry. No statistically significant difference in apoptosis rate was found between exposed and control neurons at either time point. All three assessment methods gave concordant results.
Inomata-Terada S et al. · 2007
They also assessed short-interval intracortical inhibition reflecting GABAergic interneuron function using paired-pulse TMS. No effects of exposure were found on MEPs or SICI in healthy volunteers, and no effects on MEPs were observed in two multiple sclerosis patients despite conduction block after a hot bath.
Haarala C et al. · 2007
Researchers studied the effects of continuous wave and pulsed wave electromagnetic fields on cognitive function in 36 healthy male subjects. Subjects performed cognitive tasks during exposure to continuous wave, pulsed wave, and sham fields, with left- and right-sided exposure in a double-blind design. No effects were found between EMF conditions, hemisphere exposures, or between the control and experimental groups.
Fritzer G et al. · 2007
Roosli M, Michel G, Kuehni CE, Spoerri A · 2007
Researchers used Swiss national mortality registry data from 1969 to 2002 to calculate age-standardized brain tumour mortality rates per 100,000 person-years. The study period was split before and after 1987 when analogue mobile technology was introduced. Over the whole period, mortality increased significantly in older age groups (60-74 and 75+ years) but not in younger groups. From 1987 onward, brain tumour mortality rates were relatively stable in all age groups.
Landgrebe M et al. · 2007
Researchers measured cortical excitability parameters using transcranial magnetic stimulation in 23 subjectively electrosensitive patients and two control groups totaling 49 participants with varying levels of unspecific health complaints. Electrosensitive patients showed reduced intracortical facilitation compared to both control groups. Motor thresholds and intracortical inhibition were unaffected in electrosensitive patients relative to controls. The authors suggest that altered central nervous system function may account for symptom manifestation in subjectively electrosensitive patients.
Krause CM, Pesonen M, Haarala Bjornberg C, Hamalainen H. · 2007
Researchers recruited two groups of 36 male participants each, one performing an auditory memory task and the other a visual working memory task under six exposure conditions. The study aimed to partially replicate earlier work and investigate effects of mobile phone EMF on event-related desynchronisation/synchronisation EEG responses during cognitive processing. EMF exposure produced modest effects on alpha band oscillatory responses but no effects on behavioural measures. The EEG effects were varying, unsystematic, and inconsistent with previous reports.
