Effect of ELF-EMF on number of apoptotic cells; correlation with reactive oxygen species and HSP.
Garip AI, Akan Z. · 2010
View Original AbstractELF-EMF decreased apoptotic cell numbers in normal K562 cells but increased them in cells already under oxidative stress.
Plain English Summary
Researchers investigated the effect of ELF-EMF on apoptosis in K562 human leukemia cells, with and without oxidative stress, and examined links to heat-shock protein 70 levels. ELF-EMF at 1 mT and 50 Hz was applied for 3 hours, with one group of cells treated with H2O2 to induce oxidative stress and another left untreated. In cells not exposed to oxidative stress, ELF-EMF caused a decrease in the number of apoptotic cells and a slight increase in viability. In cells treated with H2O2, ELF-EMF increased the number of apoptotic cells, and hsp70 and reactive oxygen species levels were also increased.
Why This Matters
The study used K562 human leukemia cells, splitting them into groups that either received oxidative stress via H2O2 or remained untreated before ELF-EMF exposure. The researchers found that the direction of the effect on apoptosis depended on whether cells were already under oxidative stress. In unstressed cells, ELF-EMF was associated with fewer apoptotic cells, alongside higher hsp levels. In oxidative-stress-induced cells, ELF-EMF was associated with more apoptotic cells and higher reactive oxygen species levels.
Exposure Details
- Magnetic Field
- 1 mT
- Source/Device
- 50 Hz
- Exposure Duration
- 3 hours
Exposure Context
This study used 1 mT for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
In this study the effect of ELFEMF on the number of apoptotic cells of K562 human leukemia cell line induced or not with oxidative stress and the correlation with heat-shock protein 70 (hsp70) levels was investigated.
One sample was treated with H 2 O 2 while the other was left untreated. ELF-EMF (1 mT, 50 Hz) was ap...
ELF-EMF alone caused a decrease in the number of apoptotic cells and a slight increase in viability....
These results show that the effect of ELF-EMF on biological systems depends on the status of the cell: while in cells not exposed to oxidative stress it is able to decrease the number of apoptotic cells by inducing an increase in hsp levels, it increases the number of apoptotic cells in oxidative stress-induced cells.
Show BibTeX
@article{ai_2010_effect_of_elfemf_on_369,
author = {Garip AI and Akan Z.},
title = {Effect of ELF-EMF on number of apoptotic cells; correlation with reactive oxygen species and HSP.},
year = {2010},
url = {https://akjournals.com/configurable/content/journals$002f018$002f61$002f2$002farticle-p158.xml?t:ac=journals%24002f018%24002f61%24002f2%24002farticle-p158.xml},
}