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Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines.

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Patruno A, Tabrez S, Amerio P, Pesce M, Vianale G, Franceschelli S, Grilli A, Kamal MA, Reale M · 2011

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The study estimated kinetic constants of catalase, cytochrome P450, and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines exposed to ELF-EMF.

Plain English Summary

Summary written for general audiences

The study estimated kinetic constants of catalase, cytochrome P450, and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines exposed to ELF-EMF. To evaluate cellular responses to an inflammatory stimulus, both cell lines were treated with lipopolysaccharide. The effects of ELF-EMF depend upon frequency, amplitude, and length of exposure, and are also related to intrinsic susceptibility and responsiveness of different cell types.

Why This Matters

The researchers stated that ELF-EMF can influence cell proliferation, differentiation, cell cycle, apoptosis, DNA replication and protein expression, though the mechanism of this interaction is still obscure. The authors noted there is no available report on such type of kinetic study of selected enzymes in response to ELF-EMF in these cell lines. The study suggested findings may be important for ELF-EMF application particularly for wound healing, tissue regeneration, Parkinson's and Alzheimer's diseases.

Exposure Details

Magnetic Field
1 mT
Source/Device
50 Hz
Exposure Duration
25 h

Exposure Context

This study used 1 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 1 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 5 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

The aim of this study was to estimate various kinetic constants of catalase, cytochrome P450 and inducible nitric oxide synthase in response to ELF-EMF exposure in human HaCaT and THP-1 cell lines.

In order to evaluate the effect of ELF-EMF on the modulation of cellular responses to an inflammator...

To the best of our knowledge there is no available report on such type of kinetic study of selected ...

Cite This Study
Patruno A, Tabrez S, Amerio P, Pesce M, Vianale G, Franceschelli S, Grilli A, Kamal MA, Reale M (2011). Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines. CNS Neurol Disord Drug Targets. 10(8):936-944, 2011.
Show BibTeX
@article{a_2011_kinetic_study_on_the_439,
  author = {Patruno A and Tabrez S and Amerio P and Pesce M and Vianale G and Franceschelli S and Grilli A and Kamal MA and Reale M},
  title = {Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines. },
  year = {2011},
  
  url = {https://pubmed.ncbi.nlm.nih.gov/22229327/},
}
PubMed: 22229327

Cited By (15 papers)

Quick Questions About This Study

The study focused on catalase, cytochrome P450, and inducible nitric oxide synthase.
The study used human HaCaT and THP-1 cell lines.
Lipopolysaccharide was used to evaluate the effect of ELF-EMF on the modulation of cellular responses to an inflammatory stimulus.
The effects of ELF-EMF depend upon frequency, amplitude, and length of exposure, and are also related to intrinsic susceptibility and responsiveness of different cell types.
The researchers suggested findings may be important for ELF-EMF application particularly for wound healing, tissue regeneration, Parkinson's and Alzheimer's diseases.