Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines.
Patruno A, Tabrez S, Amerio P, Pesce M, Vianale G, Franceschelli S, Grilli A, Kamal MA, Reale M · 2011
View Original Abstract50 Hz electromagnetic fields altered key protective enzymes in human cells, suggesting EMFs can interfere with cellular repair mechanisms.
Plain English Summary
Researchers exposed human skin and immune cells to 50 Hz electromagnetic fields for 25 hours. The EMFs altered three key enzymes that protect cells from damage and control inflammation. These findings reveal new ways EMFs interact with cellular repair systems, potentially affecting wound healing and neurodegenerative diseases.
Why This Matters
This study adds important mechanistic evidence to our understanding of how extremely low frequency EMFs interact with cellular systems. The researchers focused on enzymes that are fundamental to cellular health - catalase protects against oxidative damage, cytochrome P450 processes toxins, and nitric oxide synthase regulates inflammation. What makes this research particularly relevant is that 50 Hz is the exact frequency of electrical power systems in most of the world. The 1 mT exposure level used here is significantly higher than typical household exposures (which range from 0.1-4 microtesla), but it's within the range you might encounter near power lines or electrical equipment. The fact that EMFs can alter these critical enzymatic processes suggests our cells are responding to electromagnetic exposures in ways that could affect their ability to repair damage and manage inflammation - two processes central to aging and disease development.
Exposure Details
- Magnetic Field
- 1 mG
- Source/Device
- 50 Hz
- Exposure Duration
- 25 h
Exposure Context
This study used 1 mG for magnetic fields:
- 50Kx above the Building Biology guideline of 0.2 mG
- 10Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The aim of this study was to estimate various kinetic constants of catalase, cytochrome P450 and inducible nitric oxide synthase in response to ELF-EMF exposure in human HaCaT and THP-1 cell lines.
In order to evaluate the effect of ELF-EMF on the modulation of cellular responses to an inflammator...
To the best of our knowledge there is no available report on such type of kinetic study of selected ...
Show BibTeX
@article{a_2011_kinetic_study_on_the_439,
author = {Patruno A and Tabrez S and Amerio P and Pesce M and Vianale G and Franceschelli S and Grilli A and Kamal MA and Reale M},
title = {Kinetic study on the effects of extremely low frequency electromagnetic field on catalase, cytochrome P450 and inducible nitric oxide synthase in human HaCaT and THP-1 cell lines. },
year = {2011},
url = {https://pubmed.ncbi.nlm.nih.gov/22229327/},
}