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Differentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses

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Ayşe IG, Zafer A, Sule O, Işil IT, Kalkan T. · 2010

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A single ELF-EMF exposure decreased differentiation in K562 cells, while daily exposures for 1 hour caused an increase in differentiation.

Plain English Summary

Summary written for general audiences

Researchers studied the effect of ELF-EMF on the differentiation of K562 cells at different time courses. A single exposure to ELF-EMF resulted in a decrease in differentiation, while ELF-EMF applied every day for 1 hour caused an increase in differentiation. ELF-EMF increased ROS levels in K562 cells not treated with hemin, but did not change ROS levels in hemin-treated cells, indicating that ROS was not the cause of the differentiation effects.

Why This Matters

The exposure used was ELF-EMF at 50 Hz and 5 mT, applied for 1 hour. One group received a single 1-hour exposure at the onset of hemin induction, while another group received daily 1-hour exposures for four days. The researchers also tested co-stressors, including magnesium and heat-shock, and found similar results. The researchers concluded that the time-course of application is an important parameter determining the physiological response of cells to ELF-EMF.

Exposure Details

Magnetic Field
5 mT
Source/Device
50 Hz
Exposure Duration
1h

Exposure Context

This study used 5 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 5 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 25 times the FCC limit
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 50 Hz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 50 HzCell phones~1 GHzWiFi2.4 GHz5G mm28 GHzLogarithmic scale

Study Details

This study investigated the effect of ELF-EMF on the differentiation of K562 cells at different time courses

ELF-EMF (50 Hz, 5 mT, 1 h) was applied at two different time-courses; first at the onset of hemin in...

While single exposure to ELF-EMF resulted in a decrease in differentiation, ELF-EMF applied everyday...

Overall, these results imply that the time-course of application is an important parameter determining the physiological response of cells to ELF-EMF.

Cite This Study
Ayşe IG, Zafer A, Sule O, Işil IT, Kalkan T. (2010). Differentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses Electromagn Biol Med. 29(3):122-130, 2010.
Show BibTeX
@article{ig_2010_differentiation_of_k562_cells_321,
  author = {Ayşe IG and Zafer A and Sule O and Işil IT and Kalkan T. },
  title = {Differentiation of K562 Cells Under ELF-EMF Applied at Different Time Courses},
  year = {2010},
  doi = {10.3109/15368378.2010.502451},
  url = {https://www.tandfonline.com/doi/abs/10.3109/15368378.2010.502451},
}
DOI: 10.3109/15368378.2010.502451

Cited By (43 papers)

Quick Questions About This Study

The study used K562 cells, investigating ELF-EMF effects on their differentiation at different time courses.
A single exposure to ELF-EMF resulted in a decrease in differentiation.
ELF-EMF applied every day for 1 hour caused an increase in differentiation.
ELF-EMF was applied at 50 Hz and 5 mT for 1 hour, at two different time-courses.
ELF-EMF increased ROS levels only in cells not treated with hemin, and did not change ROS levels in hemin-treated cells, indicating that ROS was not the cause.