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Cellular Effects

Mobile phone base station‐emitted radiation does not induce phosphorylation of Hsp27

No Effects Found

Hirose H, Sakuma N, Kaji N, Nakayama K, Inoue K, Sekijima M, Nojima T, Miyakoshi J. · 2007

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Exposure to low-level RF fields up to 800 mW/kg did not induce phosphorylation of hsp27 or expression of hsp genes in human cells.

Plain English Summary

Summary written for general audiences

Researchers performed an in vitro study of low-level RF fields from IMT-2000 base stations to test if modulated signals cause hsp27 phosphorylation and overexpression. No significant differences in phosphorylated hsp27 at serine 82 or in hsp gene expression were found between exposed and sham-exposed groups.

Why This Matters

The study first evaluated human cell responses at a SAR of 80 mW/kg, which corresponds to the ICNIRP guideline limit for general public whole-body exposure. It then investigated whether CW and W-CDMA modulated signals at 2.1425 GHz induced activation or gene expression of hsp27 and other heat shock proteins.

Exposure Details

SAR
0.08, 0.25, 0.8 W/kg
Source/Device
2.1425 GHz
Exposure Duration
continuous for 2, 24, or 48 h for A172 cells,2 or 28 h for IMR-90 cells,24 or 48 h for A172 cells and 28 h for IMR-90 cells

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 0.08, 0.25, 0.8 W/kgExtreme Concern - 0.1 W/kgFCC Limit - 1.6 W/kgEffects observed in the Severe Concern range (Building Biology)FCC limit is 20 times higher than this level
A logarithmic frequency spectrum from 10 Hz to 100 GHz showing where this study's 2.14 GHz exposure sits relative to common EMF sources.Where This Frequency Sits on the EMF SpectrumELFVLFLF / MFHF / VHFUHFSHFmm10 Hz100 GHzThis study: 2.14 GHzPower lines50/60 Hz5G mm28 GHzLogarithmic scale

Study Details

An in vitro study focusing on the effects of low‐level radiofrequency (RF) fields from mobile radio base stations employing the International Mobile Telecommunication 2000 (IMT‐2000) cellular system was conducted to test the hypothesis that modulated RF fields act to induce phosphorylation and overexpression of heat shock protein hsp27.

First, we evaluated the responses of human cells to microwave exposure at a specific absorption rate...

Under the RF field exposure conditions described above, no significant differences in the expression...

Our results confirm that exposure to low‐level RF field up to 800 mW/kg does not induce phosphorylation of hsp27 or expression of hsp gene family.

Cite This Study
Hirose H, Sakuma N, Kaji N, Nakayama K, Inoue K, Sekijima M, Nojima T, Miyakoshi J. (2007). Mobile phone base station‐emitted radiation does not induce phosphorylation of Hsp27 Bioelectromagnetics. 28(2):99-108, 2007.
Show BibTeX
@article{h_2007_mobile_phone_base_stationemitted_2762,
  author = {Hirose H and Sakuma N and Kaji N and Nakayama K and Inoue K and Sekijima M and Nojima T and Miyakoshi J.},
  title = {Mobile phone base station‐emitted radiation does not induce phosphorylation of Hsp27},
  year = {2007},
  doi = {10.1002/bem.20277},
  url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/bem.20277},
}
DOI: 10.1002/bem.20277

Cited By (40 papers)

Quick Questions About This Study

The study tested whether modulated RF fields from mobile base stations induce phosphorylation and overexpression of heat shock protein hsp27.
Human glioblastoma A172 cells and human IMR-90 fibroblasts from fetal lungs were exposed to RF fields.
No significant differences in phosphorylated hsp27 at serine 82 or in hsp gene expression were observed between exposed and sham-exposed groups.
The researchers concluded that exposure to low-level RF fields up to 800 mW/kg does not induce phosphorylation of hsp27 or expression of the hsp gene family.