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Effect of selenium pre-treatment on plasma antioxidant vitamins A (retinol) and E (α-tocopherol) in static magnetic field-exposed rats

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Ghodbane S, Amara S, Arnaud J, Garrel C, Faure H, Favier A, Sakly M, Abdelmelek H · 2011

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In rats, short-term exposure to a static magnetic field reduced vitamin A and E levels, and selenium pre-treatment appeared to help restore antioxidant capacity.

Plain English Summary

Summary written for general audiences

Researchers exposed male adult rats to a static magnetic field (128 mT, 1 hour per day for 5 consecutive days) and measured antioxidant vitamins and markers of oxidative stress in plasma. SMF exposure increased plasma glutathione peroxidase activity by 35%, while alpha-tocopherol fell by 67% and retinol fell by 41%. SMF exposure did not alter plasma thiobarbituric acid-reactive species, total thiol groups, or selenium concentrations. Pre-treatment with selenium was associated with improved antioxidant capacities in the SMF-exposed rats.

Why This Matters

The study tested both the effect of the magnetic field alone and the effect of combining the field with selenium supplementation. The magnetic field exposure was described as sub-acute, applied at 128 mT for 1 hour per day over 5 consecutive days. Selenium was given orally at 0.2 mg/L for 30 consecutive days. The researchers concluded that sub-acute SMF exposure induced oxidative stress that may be prevented by selenium pre-treatment.

Exposure Details

Magnetic Field
128 mT
Exposure Duration
1 h/day during 5 consecutive days

Exposure Context

This study used 128 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 128 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 640 times the FCC limit

Study Details

In the present study, we evaluate the effect of the co-exposure to static magnetic field (SMF) and selenium (Se) on the antioxidant vitamins A and E levels and some other parameters of oxidative stress in rat.

Sub-acute exposure of male adult rats to a uniform SMF (128 mT, 1 h/day during 5 consecutive days) i...

Our investigation demonstrated that sub-acute exposure to SMF induced oxidative stress, which may be prevented by a pretreatment with selenium.

Cite This Study
Ghodbane S, Amara S, Arnaud J, Garrel C, Faure H, Favier A, Sakly M, Abdelmelek H (2011). Effect of selenium pre-treatment on plasma antioxidant vitamins A (retinol) and E (α-tocopherol) in static magnetic field-exposed rats Toxicol Ind Health. 27(10):949-955, 2011a.
Show BibTeX
@article{s_2011_effect_of_selenium_pretreatment_370,
  author = {Ghodbane S and Amara S and Arnaud J and Garrel C and Faure H and Favier A and Sakly M and Abdelmelek H},
  title = {Effect of selenium pre-treatment on plasma antioxidant vitamins A (retinol) and E (α-tocopherol) in static magnetic field-exposed rats},
  year = {2011},
  doi = {10.1177/0748233711401261},
  url = {https://journals.sagepub.com/doi/abs/10.1177/0748233711401261},
}
DOI: 10.1177/0748233711401261

Cited By (12 papers)

Quick Questions About This Study

The study used a uniform static magnetic field at 128 mT, applied for 1 hour per day over 5 consecutive days.
Alpha-tocopherol (vitamin E) decreased by 67% and retinol (vitamin A) decreased by 41% following SMF exposure.
Plasma thiobarbituric acid-reactive species, total thiol groups, and selenium concentrations were not altered by SMF exposure.
Selenium administration ameliorated antioxidant capacities in SMF-treated rats, and the researchers suggested it may prevent the oxidative stress induced by SMF.
The researchers concluded that sub-acute SMF exposure induced oxidative stress, which may be prevented by a pretreatment with selenium.