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Oxidative Stress

Static magnetic field exposure-induced oxidative response and caspase-independent apoptosis in rat liver: effect of selenium and vitamin E supplementations.

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Ghodbane S, Ammari M, Lahbib A, Sakly M, Abdelmelek H. · 2015

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Exposure to a static magnetic field increased liver catalase activity and triggered hepatocyte apoptosis in rats, but selenium and vitamin E supplementation could not reverse the apoptosis.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to a static magnetic field of 128 mT for one hour per day over five consecutive days and measured oxidative stress and apoptosis in the brain and liver. The exposure increased catalase activity by 24% in the liver but not in the brain, while malondialdehyde concentration was unchanged in both tissues. Static magnetic field exposure also induced hepatocyte apoptosis through a caspase-independent pathway involving mitochondrial apoptosis-inducing factor, but no such effect was found in the brain. Selenium and vitamin E supplementation restored liver catalase activity in exposed rats but did not reduce liver apoptosis.

Why This Matters

The study also examined whether selenium and vitamin E could protect against the effects of static magnetic field exposure in rat tissues. While the supplements were able to normalize the elevated liver catalase activity, they could not reduce the apoptosis that the static magnetic field had triggered in liver cells. The apoptosis observed in hepatocytes was described as caspase-independent and involved mitochondrial apoptosis-inducing factor.

Exposure Details

Magnetic Field
128 mT
Exposure Duration
1 h/day during five consecutive days

Exposure Context

This study used 128 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 128 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 640 times the FCC limit

Study Details

In the present study, we investigated the implication of oxidative stress and apoptosis under static magnetic field (SMF) in the brain and liver.Moreover, we estimated the protective role of selenium and vitamin E in rat tissues against disorders induced by SMF.

Exposure of rats to SMF (128 mT, 1 h/day during five consecutive days) increased the activity of cat...

Cite This Study
Ghodbane S, Ammari M, Lahbib A, Sakly M, Abdelmelek H. (2015). Static magnetic field exposure-induced oxidative response and caspase-independent apoptosis in rat liver: effect of selenium and vitamin E supplementations. Environ Sci Pollut Res Int. 22(20):16060-16066, 2015a.
Show BibTeX
@article{s_2015_static_magnetic_field_exposureinduced_373,
  author = {Ghodbane S and Ammari M and Lahbib A and Sakly M and Abdelmelek H.},
  title = {Static magnetic field exposure-induced oxidative response and caspase-independent apoptosis in rat liver: effect of selenium and vitamin E supplementations.},
  year = {2015},
  doi = {10.1007/s11356-015-4802-2},
  url = {https://link.springer.com/article/10.1007/s11356-015-4802-2},
}
DOI: 10.1007/s11356-015-4802-2

Cited By (12 papers)

Quick Questions About This Study

Rats were exposed to a static magnetic field of 128 mT for one hour per day over five consecutive days.
Liver catalase activity increased by 24% following static magnetic field exposure, while brain catalase activity was not altered.
Static magnetic field exposure induced hepatocyte apoptosis through a caspase-independent pathway involving mitochondrial apoptosis-inducing factor.
Selenium and vitamin E supplementation restored liver catalase activity in exposed rats but failed to minimize liver apoptosis.
Static magnetic field exposure failed to alter malondialdehyde concentration in either the brain or the liver.