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Oxidative Stress

Does static magnetic field-exposure induced oxidative stress and apoptosis in rat kidney and muscle? Effect of vitamin E and selenium supplementations.

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Ghodbane S, Lahbib A, Ammari M, Sakly M, Abdelmelek H. · 2015

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Exposure to a static magnetic field increased oxidative stress markers in rat kidney, an effect that selenium or vitamin E supplementation could prevent.

Plain English Summary

Summary written for general audiences

Researchers exposed rats to a static magnetic field at 128 mT for one hour per day over five days and measured catalase activity, malondialdehyde concentration, and apoptosis inducing factor labeling in kidney and muscle. SMF exposure increased MDA concentrations by 25% and CAT activities by 34% in kidney, but not in muscle. The treatment failed to induce caspase-independent pathway apoptosis in both kidney and muscle. Selenium pre-treatment inhibited both the MDA and CAT increases in kidney, while vitamin E corrected only MDA levels in rat kidney.

Why This Matters

The study's aim was to examine whether SMF induces oxidative stress and apoptosis in rat tissues and to evaluate the possible protective effect of selenium and vitamin E supplementations. Rats were randomly divided into control, SMF-exposed, selenium-treated, vitamin E-treated, SMF-exposed with selenium, and SMF-exposed with vitamin E groups. The oxidative stress effects were tissue-specific, appearing in kidney but not in muscle. Selenium inhibited both MDA and CAT increases in the kidney, whereas vitamin E corrected only MDA levels.

Exposure Details

Magnetic Field
128 mT
Exposure Duration
1 h/day for 5 days

Exposure Context

This study used 128 mT for magnetic fields:

Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.

Where This Falls on the Concern Scale

Study Exposure Level in ContextStudy Exposure Level in ContextThis study: 128 mTExtreme Concern - 5 mGFCC Limit - 2,000 mGEffects observed in the Extreme Concern range (Building Biology)This level is 640 times the FCC limit

Study Details

Our aim was to study whether SMF induces oxidative stress and apoptosis in rat tissues and to evaluate the possible protector effect of selenium (Se) and vitamin E (vit E) supplementations.

Rats were randomly divided into control, SMF-exposed, Se-treated, vit E-treated, SMF exposed rats an...

Exposure of rats to SMF (128 mT, 1 h/day for 5 days) increased the MDA concentrations (+25%) and CAT...

In conclusion, exposure to SMF induced oxidative stress in kidney that can be prevented by treatment with Se or vit E.

Cite This Study
Ghodbane S, Lahbib A, Ammari M, Sakly M, Abdelmelek H. (2015). Does static magnetic field-exposure induced oxidative stress and apoptosis in rat kidney and muscle? Effect of vitamin E and selenium supplementations. Gen Physiol Biophys. 34(1):23-32, 2015b.
Show BibTeX
@article{s_2015_does_static_magnetic_fieldexposure_374,
  author = {Ghodbane S and Lahbib A and Ammari M and Sakly M and Abdelmelek H.},
  title = {Does static magnetic field-exposure induced oxidative stress and apoptosis in rat kidney and muscle? Effect of vitamin E and selenium supplementations.},
  year = {2015},
  
  url = {https://europepmc.org/article/med/25395602},
}
PubMed: 25395602

Cited By (15 papers)

Quick Questions About This Study

Rats were exposed to a static magnetic field at 128 mT for one hour per day for five days.
MDA concentrations increased by 25% and CAT activities increased by 34% in kidney following SMF exposure.
The treatment failed to induce caspase-independent pathway apoptosis in both kidney and muscle.
Selenium inhibited the increase of both MDA concentrations and CAT activities in kidney, while vitamin E corrected only MDA levels.
Oxidative stress markers increased in kidney but not in muscle following SMF exposure.