Li CY, Liu CC, Chang YH, Chou LP, Ko MC. · 2012
Researchers conducted a population-based case-control study in Taiwan of children aged 15 or younger diagnosed with neoplasms between 2003 and 2007. Exposure to radiofrequency radiation was estimated from the annual power density of mobile phone base stations in each township over the five years before diagnosis. Higher-than-median exposure was significantly associated with increased odds of all neoplasms combined, but not with leukemia or brain neoplasms individually.
Divan HA, Kheifets L, Obel C, Olsen J · 2012
Researchers analyzed a new dataset of DNBC children to see if a larger group would produce similar results after considering additional confounders. The highest odds ratio for behavioral problems was observed in children with both prenatal and postnatal cell phone exposure compared to unexposed children, with an adjusted effect estimate of 1.5 (95% CI 1.4 to 1.7). The findings replicated earlier results showing an association between cell phone use and behavioral problems at age 7 years, not limited to early users. Although the association was weaker in the new dataset, it remained after further control for an extended set of potential confounders.
Tsybulin O, Sidorik E, Kyrylenko S, Henshel D, Yakymenko I. · 2012
Researchers exposed fresh fertilized Japanese quail eggs to GSM 900 MHz cell phone radiation at 0.2 μW/cm² for either 38 hours or 14 days. The 38-hour exposure significantly increased the number of differentiated somites, and the 14-day exposure significantly increased total embryo survival. Hatchlings from exposed eggs showed significantly higher levels of thiobarbituric acid reactive substances in brain and liver tissue.
Güler G et al. · 2012
Researchers exposed infant rabbits to 1800 MHz GSM-like RF radiation and measured lipid peroxidation and DNA damage in their livers. Lipid peroxidation levels in liver tissue increased in both female and male infant rabbits under RF radiation exposure. Liver 8-OHdG levels, a marker of DNA damage, increased in exposed female rabbits but showed no change in exposed male rabbits. The researchers concluded that GSM-like RF radiation may induce biochemical changes by increasing free radical attacks to structural biomolecules in the rabbit model.
Schmid MR et al. · 2012
Twenty-five young healthy men took part in a randomized double-blind crossover design, exposed at weekly intervals to different conditions for 30 minutes before sleep. The conditions were a 2-Hz pulse-modulated radio frequency field, a 2-Hz pulsed magnetic field, and sham. Radio frequency exposure increased electroencephalogram power in the spindle frequency range. Delta and theta activity during non-rapid eye movement sleep, and alpha and delta activity during rapid eye movement sleep, were affected following both exposure conditions. No effect on sleep architecture and no clear impact of exposure on cognition was observed.
Schmid MR et al. · 2012
Thirty young healthy men were exposed, at weekly intervals, for 30 minutes directly before an 8-hour sleep period to a 900-MHz RF EMF pulse-modulated at 14 Hz, at 217 Hz, or to a sham control. EEG power in the spindle frequency range was increased during non-rapid eye movement sleep after the 14-Hz pulse-modulated condition, while a similar but non-significant increase was also observed after the 217-Hz condition. No clear exposure-related effects on cognitive performance were seen, and the exposure-induced effect showed considerable individual variability.
Bouji M, Lecomte A, Hode Y, de Seze R, Villégier AS · 2012
Researchers assessed the effects of a single GSM exposure at 900 MHz with a specific absorption rate of 6 W/kg on young adult (6-week-old) and middle-aged (12-month-old) rats. The study measured brain IL-1β and IL-6, plasmatic corticosterone levels, and emotional memory. Results showed an IL-1β increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, while plasmatic corticosterone levels increased in GSM-exposed young adults. Acute GSM exposure did not induce astrocyte activation, in contrast to previously published work.
Lindholm H et al. · 2011
Each exposure and sham period lasted 15 minutes and took place in a climatic chamber under controlled thermoneutral conditions. They measured ear canal temperature, skin temperature at multiple sites, local cerebral blood flow via near-infrared spectroscopy, and autonomic nervous system function via ECG and continuous blood pressure. During the short-term RF exposure, local cerebral blood flow did not change, ear canal temperature did not increase significantly, and autonomic nervous system function was not interfered with.
Lee HJ et al. · 2011
Six-week-old AKR/J mice were simultaneously exposed to CDMA and WCDMA RF-EMFs for 45 minutes per day, five days per week, for 42 weeks. The whole-body average SAR was 2.0 W/kg for each signal, totaling 4.0 W/kg. No differences were found in final survival, lymphoma incidence, or splenomegaly incidence between sham- and RF-exposed mice. However, brain metastasis infiltration in lymphoma-bearing mice was significantly different in RF-exposed mice compared to sham-exposed mice, with no consistent correlation between sexes. Infiltration to liver, lung, and spleen did not differ between groups.
Aydin D et al. · 2011
The CEFALO study included children and adolescents aged 7–19 years diagnosed with brain tumors between 2004 and 2008 in Denmark, Sweden, Norway, and Switzerland. Researchers interviewed 352 case patients and 646 control subjects matched by age, sex, and geographical region. Regular mobile phone users did not have a statistically significant increase in brain tumor risk compared with nonusers. No increased risk was found for brain areas receiving the highest exposure, and no exposure–response relationship was observed.
Watilliaux A, Edeline JM, Lévêque P, Jay TM, Mallat M · 2011
Researchers exposed young rats on postnatal days 5, 15, or 35 to a GSM 1,800 MHz signal for 2 hours at 1.7–2.5 W/kg SAR and compared them to pseudo-exposed littermates. Western blotting measured heat shock proteins HSP60, HSC70, HSP90, serine racemase, glutamate transporters GLT1 and GLAST, and glial fibrillary acidic protein GFAP in total and soluble extracts. The GSM signal had no significant effect on any of these proteins, and immunohistochemical staining for CD68 showed no differences in microglial morphology or distribution.
Sauter C et al. · 2011
Researchers tested 30 healthy young men exposed to GSM 900, WCDMA, and sham signals over nine study days. After correction for multiple testing, only time-of-day effects remained significant in two tests, resulting in faster reactions in the afternoon trials. Univariate comparisons revealed significant changes for GSM 900 only in the vigilance test. WCDMA exposure altered one parameter in vigilance and one in divided attention, while selective attention and the n-back task were not affected by either exposure.
Divan HA, Kheifets L, Olsen J · 2011
Researchers used data from the Danish National Birth Cohort to examine prenatal cell phone use and developmental milestone delays in offspring up to 18 months of age. At 6 months the adjusted odds ratio for cognitive/language delay was 0.8 (95% CI 0.7-1.0) and for motor delay was 0.9 (95% CI 0.8-1.1). At 18 months the adjusted odds ratio for cognitive/language delay was 1.1 (95% CI 0.9-1.3) and for motor delay was 0.9 (95% CI 0.8-1.0). The researchers observed no evidence of an association and dose-response associations were also null.
Thomée S, Härenstam A, Hagberg M. · 2011
The study included 4156 young adults aged 20-24 who completed questionnaires at baseline and 1-year follow-up. Mobile phone exposure variables included frequency of use and qualitative aspects such as demands on availability, perceived stressfulness of accessibility, being awakened at night, and personal overuse. Cross-sectionally, high mobile phone use was linked to stress, sleep disturbances, and depression symptoms in both sexes; prospectively, high use predicted sleep disturbances and depression symptoms in men and depression symptoms in women, while overuse predicted stress and sleep disturbances in women and high accessibility stress predicted stress, sleep disturbances, and depression symptoms in both sexes.
Keshvari J, Heikkilä T. · 2011
Researchers investigated SAR differences in child and adult head models using CAD models of commercial mobile phones as exposure sources. The main finding was that SAR distribution depends highly on antenna structure and phone model, making the exposure source type the key parameter. No systematic differences between child and adult heads were found from a volume-averaged SAR perspective. SAR values from generic source models could not be extrapolated to real device exposures.
Aydin D et al. · 2011
Researchers performed simulations using real data from the CEFALO case–control study to assess how recall errors and selection bias affect odds ratios for mobile phone use and brain tumor risk in children and adolescents. In a validation study, cases overestimated their number of calls by 9% on average and controls by 34%, while cases overestimated call duration by 52% and controls by 163%. Participation rates were 83% for cases and 71% for controls, and the combined impact of recall error and selection bias on estimated odds ratios was complex across various scenarios.
Noor NA, Mohammed HS, Ahmed NA, Radwan NM · 2011
Leung S et al. · 2011
This study examined sensory and cognitive processing in adolescents, young adults and older adults when exposed to 2G and 3G mobile phone signals. Forty-one 13–15 year olds, forty-two 19–40 year olds and twenty 55–70 year olds were tested using a double-blind cross-over design, where each participant received Sham, 2G and 3G exposures, separated by at least 4 days. On a memory task, adolescents performed less accurately during 3G exposure compared to Sham, and delayed brainwave responses were found in both 2G and 3G conditions across all age groups.
Kwon MS et al. · 2011
Researchers used positron emission tomography with an 18F-deoxyglucose tracer to investigate the effects of mobile phone radiation on cerebral glucose metabolism in humans. Thirteen young right-handed male subjects were exposed to a pulse-modulated 902.4 MHz Global System for Mobile Communications signal for 33 minutes while performing a simple visual vigilance task. The relative cerebral metabolic rate of glucose was significantly reduced in the temporoparietal junction and anterior temporal lobe of the right hemisphere, on the same side as the exposure. The exposure did not affect task performance, measured by reaction time and error rate.
Parazzini M et al. · 2010
Researchers investigated the potential effects of UMTS exposure at a high specific absorption rate on the human auditory system in 73 healthy young adults. Participants received a 20-minute UMTS exposure at 1947 MHz with a maximum SAR of 1.75 W/kg in a double-blind comparison of genuine and sham exposure. No consistent pattern of effects was found on hearing thresholds, otoacoustic emissions, or auditory evoked potentials. The study concluded that short-term UMTS exposure at this SAR does not cause measurable immediate effects on the human auditory system.
Inskip PD, Hoover RN, Devesa SS. · 2010
Researchers examined temporal trends in brain cancer incidence rates in the United States using SEER program data from 1992 to 2006. Trends were downward or flat for all age groups except 20- to 29-year-olds, where females showed a statistically significant increase. The increase in young women was driven by frontal lobe cancers, while cancers in brain regions more exposed to phone radiation did not increase. The authors concluded that the incidence data do not support the view that cellular phone use causes brain cancer.
Kwon MS et al. · 2010
Auditory event-related potentials including P1, N2, mismatch negativity, and P3a were recorded from 17 children aged 11–12 years using the multi-feature paradigm. During recording, an ordinary GSM mobile phone emitting 902 MHz pulsed at 217 Hz was placed on the ear over the left or right temporal area with SAR1g = 1.14 W/kg and SAR10g = 0.82 W/kg. The short exposure of two 6 min blocks per side had no statistically significant effects on the neural change-detection profile measured with MMN. The study only had sufficient statistical power to detect a large effect size.
Kwon MS, Jääskeläinen SK, Toivo T, Hämäläinen H. · 2010
Researchers investigated the effects of a GSM mobile phone electromagnetic field on brainstem auditory processing. Auditory brainstem responses were recorded in 17 healthy young adults at baseline without a phone and then with a phone on the ear under EMF-off and EMF-on conditions. ABR waveforms showed no significant differences due to exposure.
Vrijheid M et al. · 2010
A birth cohort was established in Sabadell, Spain between 2004 and 2006. Mothers completed questions about cell phone use in week 32 of pregnancy (n = 587) and their children's neurodevelopment was tested at 14 months using the Bayley Scales of Infant Development (n = 530). We observed only small differences in neurodevelopment scores between the offspring of cell phone users and nonusers. Those of users had higher mental development scores and lower psychomotor development scores, which may be due to unmeasured confounding, and there was no trend with amount of cell phone use within users.
Heinrich S, Thomas S, Heumann C, von Kries R, Radon K. · 2010
A population-based cross-sectional study in Germany from 2006 to 2008 generated 24-hour exposure profiles for 1484 children and 1508 adolescents using personal dosimeters. Acute symptoms were assessed twice daily with a symptom diary, and only a few statistically significant associations were found, including higher headache intensity in adolescents with highest morning exposure at noon and higher irritation and concentration problem intensities at bedtime. The authors observed that the few significant results were not consistent over the two time points, could not be confirmed in the top 10% highest exposure group, and concluded the associations likely occurred by chance.
