Effects of fifty-hertz electromagnetic fields on granulocytic differentiation of ATRA-treated acute promyelocytic leukemia NB4 cells.
Errico Provenzano A, Amatori S, Nasoni MG, Persico G, Russo S, Mastrogiacomo AR, Gambarara A, Fanelli M. · 2018
View Original AbstractExposure to ELF-EMF promotes ATRA-induced granulocytic differentiation of acute promyelocytic leukemia NB4 cells.
Plain English Summary
Researchers studied the effects of extremely low frequency electromagnetic fields on the differentiation process of acute promyelocytic leukemia NB4 cells that were also treated with ATRA. The NB4 cells used were a cell line established from the bone marrow of a patient affected by acute promyelocytic leukemia. ELF-EMF exposure decreased cellular proliferation potential and helped ATRA-treated NB4 cells to mature. The results indicated that ELF-EMF exposure promotes ATRA-induced granulocytic differentiation of these leukemia cells.
Why This Matters
The researchers monitored cellular proliferation and morphology, nitroblue tetrazolium (NBT) reduction, and the expression of differentiation surface markers to assess the effects of the fields. They also investigated mechanisms by focusing on reactive oxygen species (ROS) generation and related molecular pathways. The analysis of ROS production and the consequent ERK1/2 phosphorylation suggested that a changed intracellular oxidative balance may influence the biological effects of ELF-EMFs.
Exposure Details
- Magnetic Field
- 2 mT
- Source/Device
- 50Hz
Exposure Context
This study used 2 mT for magnetic fields:
- 100Kx above the Building Biology guideline of 0.2 mG
- 20Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
To study the effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells
We studied the effects of ELF-EMFs (50 Hz, 2 mT) on the ATRA-mediated granulocytic differentiation p...
ELF-EMF exposure decreases cellular proliferation potential and helps ATRA-treated NB4 cells to matu...
These results indicate that the exposure to ELF-EMF promotes ATRA-induced granulocytic differentiation of APL cells.
Show BibTeX
@article{a_2018_effects_of_fiftyhertz_electromagnetic_355,
author = {Errico Provenzano A and Amatori S and Nasoni MG and Persico G and Russo S and Mastrogiacomo AR and Gambarara A and Fanelli M.},
title = {Effects of fifty-hertz electromagnetic fields on granulocytic differentiation of ATRA-treated acute promyelocytic leukemia NB4 cells.},
year = {2018},
url = {https://www.karger.com/Article/Abstract/488473},
}