Cytotoxic effects of moderate static magnetic field exposure on human periphery blood mononuclear cells are influenced by Val16Ala-MnSOD gene polymorphism.
Dornelles EB, Goncalves BD, Schott KL, Barbisan F, Unfer TC, Glanzner WG, Machado AK, Cadona FC, Azzolin VF, Montano MA, Griner J, da Cruz IB. · 2017
View Original AbstractA 5 mT static magnetic field showed cytotoxic effects on human blood cells, with the strongest impact seen in cells carrying the AA variant of the Val16Ala-MnSOD gene polymorphism.
Plain English Summary
Researchers tested the in vitro cytotoxic effects of a 5 mT static magnetic field on human blood cells carrying different variants of the Val16Ala polymorphism in the manganese superoxide dismutase gene. Cytotoxic effects were observed in AA cells at all exposure times, while AV cells showed higher mortality only after 6 hours, and higher apoptosis induction was seen in AA cells compared to VV and AV cells. The authors suggest the results indicate a toxicogenetic effect of the static magnetic field related to an imbalance in SOD2 activity.
Why This Matters
The study was conducted in vitro, with cells tested outside a living person. The VV genotype produces a less efficient SOD2 enzyme while the AA genotype produces a more efficient one. Homozygous Val16Ala-SOD2 genotypes are described as presenting oxidative imbalance associated with risk to several chronic degenerative diseases. Blood samples from healthy adult subjects with different Val16Ala-SOD2 genotypes were exposed to the magnetic field at different times of 0, 1, 3, and 6 hours, and cytotoxic effects and oxidative stress were evaluated after incubation of 24 hours at 37 °C. Apoptosis induction was analyzed by flow cytometry as well as by measuring expression of BAX, BCL-2, and caspases 8 and 3 genes.
Exposure Details
- Magnetic Field
- 5 mT
- Exposure Duration
- 0, 1, 3, 6 h
Exposure Context
This study used 5 mT for magnetic fields:
- 250Kx above the Building Biology guideline of 0.2 mG
- 50Kx above the BioInitiative Report recommendation of 1 mG
Building Biology guidelines are practitioner-based limits from real-world assessments. BioInitiative Report recommendations are based on peer-reviewed science. Check Your Exposure to compare your own measurements.
Where This Falls on the Concern Scale
Study Details
The following study has assessed an in vitro cytotoxic effect of static magnetic field (SMF) (5 mT) on cells with Val16Ala polymorphism (AA, VA, and VV) in the manganese superoxide dismutase gene.
Homozygous Val16Ala-superoxide dismutase 2 (SOD2) genotypes present oxidative imbalance that is asso...
SMF cytotoxic effect has been observed in AA cells at all times of exposure, whereas AV cells presen...
Show BibTeX
@article{eb_2017_cytotoxic_effects_of_moderate_349,
author = {Dornelles EB and Goncalves BD and Schott KL and Barbisan F and Unfer TC and Glanzner WG and Machado AK and Cadona FC and Azzolin VF and Montano MA and Griner J and da Cruz IB.},
title = {Cytotoxic effects of moderate static magnetic field exposure on human periphery blood mononuclear cells are influenced by Val16Ala-MnSOD gene polymorphism.},
year = {2017},
url = {https://link.springer.com/article/10.1007%2Fs11356-016-8176-x},
}