Auvinen A, Hietanen M, Luukkonen R, Koskela R-S, · 2002
Researchers conducted a register-based case-control study on cellular phone use and cancer. The study included all cases of brain tumor (N = 398) and salivary gland cancer (N = 34) diagnosed in Finland in 1996, with five controls per case. Cellular phone use was not associated with brain tumors or salivary gland cancers overall. There was a weak association between gliomas and analog cellular phones.
Utteridge TD et al. · 2002
Researchers exposed 120 E-mu-Pim1 heterozygous mice and 120 wild-type mice to GSM-modulated 898.4 MHz radiation at SARs of 0.25, 1.0, 2.0, and 4.0 W/kg for 1 hour per day, 5 days per week, for up to 104 weeks. Sham-exposed groups of 120 heterozygous and 120 wild-type mice and an unrestrained negative control group were included. No significant difference in lymphoma incidence was found between exposed and sham-exposed groups at any exposure level. No dose-response effect was detected.
Paulraj R, Behari J · 2002
Researchers exposed 35-day-old Wistar rats to low-level continuous 2.45 GHz microwaves for 2 hr/day over 35 days at a power density of 0.34 mW/cm2 with a specific absorption rate of 0.1 W/kg. Exposed rats showed a significant increase in calcium ion efflux and ornithine decarboxylase activity and a significant decrease in calcium-dependent protein kinase activity in brain tissue. The authors suggested that the radiation affects membrane-bound enzymes linked to cell proliferation and differentiation, indicating a possible tumor-promoting role.
Di Carlo A, White N, Guo F, Garrett P, Litovitz T. · 2002
Chick embryos were exposed to ELF-EMFs at 8 microT continuously for 4 days, or to ELF or RF EMFs repeated daily for 4 days in sessions of 20, 30, or 60 minutes once or twice daily. Several exposure protocols produced statistically significant decreases in protection against hypoxic stress, including continuous ELF and 30 or 60 minute ELF twice daily, or 30 or 60 minute once daily RF. Following 4 days of ELF-EMF exposure, HSP70 levels declined by 27% compared to controls.
Cao XZ, Zhao ML, Wang DW, Dong B. · 2002
Researchers studied whether electromagnetic pulse (EMP) could induce apoptosis in a human lung carcinoma cell line called GLC-82. Cells were irradiated with EMP at an electric field intensity of 60 kV/m, 5 pulses per 2 minutes, and analyzed using cytometry, MTT chronometry, and flow cytometry. EMP visibly inhibited proliferation and activity of the GLC-82 cells, and the highest apoptosis rate reached 13.38% at 6 hours after irradiation. EMP also down-regulated bcl-2 expression and up-regulated p53 expression in the GLC-82 cells.
Bartsch H et al. · 2002
Researchers tested a GSM-like RF signal on mammary tumors induced by DMBA in female Sprague-Dawley rats as a model for human breast cancer. Three experiments were carried out under strictly standardized conditions using a GSM-like signal at 900 MHz pulsed at 217 Hz. The overall results showed no statistically significant effect of RF-field exposure on tumor latency, and cumulative tumor incidence was unaffected as well. The researchers concluded that low-level RF radiation does not appear to possess carcinogenic or cancer-promoting effects on DMBA-induced mammary tumors.
Unknown authors · 2001
Researchers conducted a nationwide population-based case-control study of breast cancer risk among 30- to 54-year-old Danish women who worked predominantly at night. Employment histories were reconstructed back to 1964 for 7035 women with breast cancer and their individually matched controls from a nationwide pension scheme. The odds ratio for breast cancer among women who worked at night for at least half a year was 1.5 (95% confidence interval, 1.2 to 1.7), with a tendency toward higher odds with longer duration of nighttime employment.
Unknown authors · 2001
Researchers independently replicated a study testing whether a 1.2 microT, 60 Hz magnetic field alters the effects of melatonin and tamoxifen on MCF-7 human breast cancer cells. In the melatonin experiment, repeated three times, melatonin reduced cell numbers by 16.7% after seven days, but this reduction disappeared when cells were exposed to the magnetic field. In the tamoxifen experiment, repeated nine times, tamoxifen reduced cell growth by 18.6% and 25% on days six and seven without the field, but only by 8.7% and 13.1% with the field. The results were consistent with the original findings of Harland and Liburdy.
Unknown authors · 2001
Researchers conducted a population-based case-control study across former West Germany. They measured 24-hour residential magnetic fields for 514 children with acute leukemia and 1,301 control children. Childhood leukemia and 24-hour median magnetic fields showed only a weak relationship. However, a significant association emerged for magnetic field exposure during the night.
Unknown authors · 2001
A marked excess risk was found for machinery repairers, and increased relative risks were noted for several other occupations. The relative risk for exposure above 0.12 microtesla was 1.31 (95% CI 0.94-1.81) without a clear exposure-response pattern, but intermittent exposure showed indications of an exposure-response relationship. The authors concluded there is no clear evidence for an etiological role of ELFMF in male breast cancer, but large variations in exposure over the workday may be associated with increased risk.
Unknown authors · 2001
A peak in childhood leukemia at ages two through four emerged in the 1920s in the United Kingdom and later in the United States. During 1928-1932, states with above 75% residential electrification showed increasing leukemia mortality with age, while less electrified states showed a decreasing trend. At ages 2-4, a 10% increase in home electrification was associated with a 24% increase in leukemia mortality.
Unknown authors · 2001
Analyses used dichotomous and continuous exposure models, heterogeneity assessments, influence analyses, and publication bias checks. Results were combined with national exposure data to estimate population attributable risk for U.S. children.
Unknown authors · 2001
This paper reviews 43 publications that provide information about possible associations between exposure to electric and magnetic fields (EMF) at work or at home and risks of breast cancer in women and men. Estimation of relative risk associated with exposure was possible for 24 studies among women and 15 among men. The pooled RR from studies in women was 1.12 (95% CI: 1.09, 1.15), but variations between the contributing results are not easily attributable to chance (P = 0.0365). A fairly homogeneous increased risk was found for men (a pooled RR of 1.37, with 95% confidence limits of 1.11, 1.71, and homogeneity P-value = 0.1101). However, in both genders, results from individual studies are very variable and in part contradictory.
Unknown authors · 2001
Researchers conducted a population-based case-control study of 843 breast cancer cases and 773 controls to examine occupational electromagnetic field exposure and breast cancer incidence. Exposure was classified based on the two longest-held jobs and cumulative magnetic field indices from a measurement survey. Breast cancer was not associated with office or industrial work, and cumulative exposure over the career and recent periods showed odds ratios close to null. Moderately elevated risks appeared for intermediate cumulative exposure 20 or more years ago (OR=1.5, 95% CI=1.1-2.0), with stronger associations for premenopausal women (OR=1.7, 95% CI=1.1-2.7) and ER+ tumors (OR=2.06, 95% CI=1.1-4.0), but no consistent dose-response patterns were observed.
Unknown authors · 2001
Unknown authors · 2001
Unknown authors · 2001
They concluded that study quality has improved and recent studies on childhood leukemia and occupational cancer approach the limits of feasible size and rigor. The review found no chronic disease with an established etiological relation to EMF. Childhood leukemia showed the strongest association with postnatal exposures above 0.4 microtesla (relative risk 2.0, 95% CI 1.27-3.13), and amyotrophic lateral sclerosis showed an association with occupational exposure that could be due to confounding.
Unknown authors · 2001
Researchers evaluated leukemia mortality among adults and childhood leukemia incidence in a 10 km area around the Vatican Radio Station in Rome. The station transmitted up to 600 kW and electric field measurements near it ranged from 1.5 to 25 V/m. Childhood leukemia incidence was higher than expected within 6 km (SIR = 217; 95% CI 99-405), and Stone's test showed a significant decrease in risk with distance for male adult mortality (p = 0.03) and childhood incidence (p = 0.04).
Zook BC, Simmens SJ, · 2001
Researchers exposed Sprague-Dawley rats to 860 MHz pulsed or continuous radiofrequency radiation for 6 hours per day, 5 days per week from 2 up to 24 months of age. The specific absorption rate was 1.0 W/ kg averaged over the brain. The rats were offspring of females injected intravenously with 0, 2.5, or 10 mg/kg ethylnitrosourea to induce brain tumors. There was no statistically significant evidence that the radiation induced neoplasia in any tissues or promoted cranial or spinal nerve or spinal cord tumors. The radiation had no statistically significant effect on brain tumor number, volume, location, multiplicity, histological type, malignancy, or fatality.
Roti Roti JL et al. · 2001
Researchers measured the effect of 835.62 MHz FDMA and 847.74 MHz CDMA radiation on neoplastic transformation frequency using the in vitro C3H 10T(1/2) cell transformation assay system. Cells were exposed at 37°C to either radiation at a specific absorption rate of 0.6 W/kg for 7 days to test for genotoxic effects, or after 4.5 Gy X-ray exposure for 42 days to test for epigenetic promotion effects. After both the 7-day and 42-day exposures, no statistically significant differences in transformation frequencies were found between incubator controls, sham-exposed groups, and RF-exposed groups.
Mason PA et al. · 2001
In this study we investigated whether a single (1.0 W/cm(2) for 10 s) or repeated (2 exposures/week for 12 weeks, 333 mW/cm(2) for 10 s) exposure to 94 GHz RFR serves as a promoter or co-promoter in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced SENCAR mouse model of skin carcinogenesis. Neither paradigm of MMW exposure significantly affected papilloma development, as evidenced by a lack of effect on tumor incidence and multiplicity. There was also no evidence that MMW exposure served as a co-promoter in DMBA-induced animals repeatedly treated with 12-O-tetradecanoylphorbol 13-acetate.
Johansen C, Boice JD, McLaughlin JK, Olsen JH, · 2001
A retrospective cohort study in Denmark included 420 095 cellular telephone users from 1982 through 1995. Cancer incidence was determined by linkage with the Danish Cancer Registry. Overall, 3391 cancers were observed with 3825 expected, yielding a significantly decreased standardized incidence ratio of 0.89. No excess risk was found for brain or nervous system tumors, salivary gland cancer, or leukemia. The results do not support an association between cellular telephone use and these cancers.
Jauchem JR, Frei MR, Dusch SJ, Lehnert HM, Kovatch RM · 2001
Researchers exposed 100 C3H/HeJ mice to ultra-wideband electromagnetic pulses for 2 minutes once a week for 12 weeks, using 100 sham-control mice for comparison. There were no significant differences between groups in incidence of palpated mammary tumors, latency to tumor onset, rate of tumor growth, or animal survival. Histopathological evaluations also revealed no significant differences between the two groups in numbers of neoplasms across all tissues studied.
Inskip PD et al. · 2001
Researchers conducted a case-control study of intracranial tumors between 1994 and 1998. They enrolled 782 patients with glioma, meningioma, or acoustic neuroma and 799 controls. Cumulative use of more than 100 hours showed relative risks of 0.9 for glioma, 0.7 for meningioma, 1.4 for acoustic neuroma, and 1.0 for all tumors combined. No higher risks were seen for use of 60 or more minutes per day or regular use for five or more years. Tumors did not occur more often on the side of the head where the telephone was typically used.
Higashikubo R et al. · 2001
Researchers exposed mouse C3H 10T(1/2) fibroblasts and human U87MG glioma cells to two types of radiofrequency fields at 0.6 W/kg. Five cell cycle parameters including transit through G1, G2, and S phase and probability of cell division were measured immediately and up to 100 hours. No changes in cell cycle parameters were observed in exposed cells compared to sham-exposed cells in either cell line during the entire experimental period.
