3,138 Studies Reviewed. 77.4% Found Biological Effects. The Evidence is Clear.
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Immune System

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Key Finding: 77% of 274 studies on immune system found biological effects from EMF exposure.

Of 274 studies examining immune system, 77% found measurable biological effects from EMF exposure.

Lowest Documented Effect

Research found effects on immune system at exposures as low as:

Study Exposure Level in ContextA logarithmic scale showing exposure levels relative to Building Biology concern thresholds and regulatory limits.Study Exposure Level in Context0.00000052, 0.00001536, 0.00021268Extreme Concern1,000 uW/m2FCC Limit10M uW/m2Effects observed in the No Concern range (Building Biology)FCC limit is 19,230,769,230,769x higher than this exposure level

Research Overview

  • -When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF.
  • -The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
  • -Research has documented a range of immune system disruptions, from reduced white blood cell counts and altered antibody production to increased inflammatory markers and compromised cellular repair mechanisms.

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.

While we don't yet have as many studies specifically examining EMF effects on immune function as we do for other biological systems, the evidence that does exist points to concerning patterns.

Importantly, many effects occur at exposure levels below those causing significant body temperature increases, with some studies showing responses at specific absorption rates as low as 0.14 W/kg.

Source: BioInitiative Working Group. BioInitiative Report: A Rationale for Biologically-based Public Exposure Standards for Electromagnetic Radiation. Edited by Cindy Sage and David O. Carpenter, BioInitiative, 2012, updated 2020. www.bioinitiative.org

Showing 274 studies

Genetic damage in mobile phone users: some preliminary findings.

Gandhi G, Anita · 2005

Researchers tested 24 mobile phone users' blood cells for genetic damage and found significantly more DNA breaks and chromosomal abnormalities compared to non-users. The study used two different laboratory tests to measure cellular damage in white blood cells from people exposed to mobile phone radiation between 800-2000 MHz. These findings suggest that everyday mobile phone use may cause measurable genetic damage at the cellular level.

Nitric oxide level in the nasal and sinus mucosa after exposure to electromagnetic field.

Yariktas M et al. · 2005

Researchers exposed rats to 900 MHz radiofrequency radiation (the same frequency used by many cell phones) for two weeks and measured nitric oxide levels in their nasal passages. They found that EMF exposure significantly increased nitric oxide production in the nose and sinus tissues, but giving the rats melatonin prevented this increase. This suggests that cell phone radiation may trigger inflammatory responses in nasal tissues.

Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons.

Markovà E, Hillert L, Malmgren L, Persson BR, Belyaev IY. · 2005

Researchers exposed human immune cells (lymphocytes) to microwave radiation from GSM mobile phones for one hour and found it caused DNA damage markers similar to heat shock. The study examined cells from both healthy people and those who report electromagnetic hypersensitivity, finding similar responses in both groups. This demonstrates that cell phone radiation can trigger cellular stress responses and DNA damage at exposure levels well below current safety standards.

Immune System103 citations

915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons

Belyaev et al. · 2005

Researchers exposed human immune cells to cell phone radiation (915 MHz) and power line magnetic fields. Both exposures caused cellular stress responses similar to heat shock, affecting how DNA is packaged inside cells. This occurred equally in healthy people and those reporting electromagnetic sensitivity.

Studying the synergistic damage effects induced by 1.8GHz radiofrequency field radiation (RFR) with four chemical mutagens on human lymphocyte DNA using comet assay in vitro.

Baohong Wang et al. · 2005

Researchers exposed human immune cells to 1.8 GHz cell phone radiation (the same frequency used by many mobile phones) for 2-3 hours to see if it damages DNA. While the radiation alone didn't harm DNA, it significantly amplified the damage when cells were also exposed to certain toxic chemicals. This suggests cell phone radiation may make our cells more vulnerable to other environmental toxins.

Cellular Effects103 citations

915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons.

Belyaev IY et al. · 2005

Researchers exposed white blood cells from healthy people and those with electromagnetic sensitivity to cell phone radiation (915 MHz). Both groups showed identical DNA structural changes similar to heat stress, confirming that electromagnetic fields cause measurable biological effects in human cells.

Oxidative StressNo Effects Found

Evaluation of parameters of oxidative stress after in vitro exposure to FMCW- and CDMA-modulated radiofrequency radiation fields.

Hook et al. · 2004

Researchers exposed mouse immune cells to cell phone radiation at 835-847 MHz for over 20 hours to test whether radiofrequency signals cause oxidative stress (cellular damage from harmful molecules). They found no evidence that either FMCW or CDMA modulated signals at 0.8 W/kg caused oxidative stress, cellular damage, or changes in the cells' natural antioxidant defenses. The study suggests that cell phone-type radiation at these levels does not trigger the cellular stress responses that can lead to health problems.

Immune SystemNo Effects Found

1800 MHz radiofrequency (mobile phones, different global system for mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors.

Capri M et al. · 2004

Italian researchers exposed immune cells from both young and elderly people to 1800 MHz radiofrequency radiation (the type used by cell phones) at levels similar to what phones emit. They measured whether the radiation caused cell death, affected cellular energy production, or triggered stress responses. The study found no significant biological effects from the RF exposure across any of the measurements.

DNA & Genetic DamageNo Effects Found

Measurement of DNA damage and apoptosis in molt-4 cells after in vitro exposure to radiofrequency radiation.

Hook GJ et al. · 2004

Researchers exposed immune system cells (Molt-4 T lymphoblastoid cells) to cell phone radiation at various frequencies for up to 24 hours to test whether it causes DNA damage or triggers cell death. They found no statistically significant DNA damage or cell death compared to unexposed cells across all tested frequencies and modulation types. This suggests that cell phone radiation at these exposure levels may not directly harm cellular DNA or kill immune cells in laboratory conditions.

Oxidative StressNo Effects Found

Evaluation of Parameters of Oxidative Stress after In Vitro Exposure to FMCW- and CDMA-Modulated Radiofrequency Radiation Fields.

Hook et al. · 2004

Researchers exposed mouse immune cells to cell phone radiation for 20-22 hours to see if it caused oxidative stress (cellular damage from unstable molecules). The study tested two types of signals used in mobile phones at levels similar to what phones emit. No signs of oxidative stress were detected, and the cells remained healthy throughout the exposure period.

Laughter counteracts enhancement of plasma neurotrophin levels and allergic skin wheal responses by mobile phone-mediated stress.

Kimata H. · 2004

Researchers studied patients with atopic dermatitis (a chronic skin condition) to see how mobile phone use affects their allergic responses and stress markers. They found that writing messages on a mobile phone increased stress hormones and worsened allergic skin reactions, while watching comedy videos beforehand prevented these negative effects. This suggests that mobile phone use can trigger stress responses that worsen allergic conditions, but positive emotions may provide protection.

Effect of 910-MHz electromagnetic field on rat bone marrow.

Demsia G, Vlastos D, Matthopoulos DP. · 2004

Researchers exposed rats to 910-MHz radiofrequency radiation (similar to cell phone frequencies) for 2 hours daily over 30 days and examined their bone marrow for genetic damage. They found a nearly threefold increase in micronuclei, which are markers of DNA damage and chromosome breaks, in the exposed animals compared to controls. This suggests that prolonged RF exposure at cell phone frequencies may cause genetic damage in blood-forming cells.

DNA Damage of Lymphocytes in Volunteers after 4 hours Use of Mobile Phone.

Ji S, Oh E, Sul D, Choi JW, Park H, Lee E. · 2004

Researchers tested 14 healthy adults who talked on cell phones for 4 hours straight, measuring DNA damage in their blood cells before and after exposure. The study found statistically significant increases in DNA damage markers in two types of immune cells (B-cells and granulocytes) after the 4-hour phone use. This suggests that extended cell phone conversations may cause measurable genetic damage to blood cells, though the long-term health implications remain unclear.

Blood-forming system in rats after whole-body microwave exposure; reference to the lymphocytes.

Trosic I, Busljeta I, Pavicic I. · 2004

Croatian researchers exposed rats to 2.45 GHz microwave radiation (the same frequency used by WiFi and microwave ovens) for 2 hours daily over periods up to 30 days. They found that longer exposures significantly reduced lymphoblasts, which are immature immune cells that develop into infection-fighting lymphocytes. The researchers interpreted this as a stress response in the blood-forming system, suggesting the body was adapting to the microwave exposure.

Millimeter wave-induced suppression of B16 F10 melanoma growth in mice: involvement of endogenous opioids.

Radzievsky AA et al. · 2004

Researchers exposed mice with melanoma tumors to millimeter wave radiation at 61.22 GHz for 15 minutes daily over 5 days. They found that this treatment significantly slowed tumor growth, but only when started at a specific time point (day 5 after tumor injection). The anti-cancer effect was blocked when mice were given naloxone, a drug that blocks opioid receptors, suggesting the treatment works by triggering the body's natural opioid system.

The production of tumor necrosis factor in cells of tumor-bearing mice after total-body microwave irradiation and antioxidant diet.

Novoselova EG et al. · 2004

Researchers exposed tumor-bearing mice to extremely low-level microwave radiation (similar to ambient environmental levels) for 1.5 hours daily and found it actually slowed tumor growth and extended survival. The microwaves appeared to boost the immune system's production of tumor necrosis factor (TNF), a protein that helps fight cancer cells. This suggests that certain types of low-level electromagnetic exposure might have protective effects rather than harmful ones.

Nonthermal GSM microwaves affect chromatin conformation in human lymphocytes similar to heat shock.

Sarimov et al. · 2004

Researchers exposed human white blood cells (lymphocytes) to cell phone radiation at levels similar to what phones emit during calls. They found that 30-60 minutes of exposure caused changes in the DNA packaging inside cells that were similar to heat stress damage. These cellular changes occurred in most test subjects and suggest that phone radiation may trigger stress responses in our immune cells even at low power levels.

Immune System108 citations

In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential.

Capri M et al. · 2004

Researchers exposed human immune cells to cell phone radiation for three days. GSM signals (used by mobile phones) slightly reduced immune cell growth and altered cell membranes, while steady radiation showed no effects. This suggests pulsed phone signals may uniquely affect immune function.

Oxidative Stress135 citations

Acute exposure to 930 MHz CW electromagnetic radiation in vitro affects reactive oxygen species level in rat lymphocytes treated by iron ions.

Zmyslony M, Politanski P, Rajkowska E, Szymczak W, Jajte J. · 2004

Polish researchers exposed rat immune cells (lymphocytes) to 930 MHz radiation at levels similar to cell phone emissions for 5-15 minutes. While the radiation alone didn't increase harmful free radicals, it significantly amplified free radical production when cells were already under oxidative stress from iron exposure. This suggests cell phone radiation may worsen cellular damage when your immune system is already compromised.

The effect of weak 50 Hz magnetic fields on the number of free oxygen radicals in rat lymphocytes in vitro

Zmyslony M, Rajkowska E, Mamrot P, Politanski P, Jajte J · 2004

Polish researchers exposed rat immune cells to weak magnetic fields similar to those near power lines. When aligned with Earth's magnetic field, 40 microtesla exposure significantly reduced free radicals - harmful molecules that damage cells. This shows even very weak power-frequency fields can alter basic cellular processes.

Cell activating capacity of 50 Hz magnetic fields to release reactive oxygen intermediates in human umbilical cord blood-derived monocytes and in Mono Mac 6 cells.

Lupke M, Rollwitz J, Simkó M. · 2004

German researchers exposed human immune cells (monocytes) to 50 Hz magnetic fields for 45 minutes and measured their production of reactive oxygen species (ROS), which are damaging molecules that contribute to cellular stress and disease. They found that magnetic field exposure increased ROS production by 20-50% in these immune cells. This matters because elevated ROS levels are linked to inflammation, aging, and various health problems.

Learn More

For a comprehensive exploration of EMF health effects including immune system, along with practical protection strategies, explore these books by R Blank and Dr. Martin Blank.

FAQs: EMF & Immune System

When 106 out of 129 studies (82.2%) document immune system effects from electromagnetic field exposure, we're looking at one of the most consistently demonstrated biological impacts of EMF. The science demonstrates that your body's natural defense system responds to wireless radiation in ways that can compromise your ability to fight infections, heal from injuries, and maintain optimal health.
The BioInitiative Report database includes 274 peer-reviewed studies examining the relationship between electromagnetic field exposure and immune system. These studies have been conducted by researchers worldwide and published in scientific journals. The research spans multiple decades and includes various types of EMF sources including cell phones, WiFi, power lines, and other common sources of electromagnetic radiation.
77% of the 274 studies examining immune system found measurable biological effects from EMF exposure. This means that 210 studies documented observable changes in biological systems when exposed to electromagnetic fields. The remaining 23% either found no significant effects or had inconclusive results, which is typical in scientific research where study design and exposure parameters vary.