Qin F, Yuan H, Nie J, Cao Y, Tong J · 2014
Researchers exposed male mice to 1800 MHz radiofrequency fields at 208 microW/cm2 for 0, 30, or 120 minutes per day for 30 days, while some groups also received nano-selenium by intra-gastric injection. Significant impairments in learning and memory were observed in the RF 120 min group, along with reduced acetylcholine levels and antioxidant enzyme activity and increased GABA, glutamate, and MDA in the brain. Nano-selenium supplementation decreased GABA, glutamate, and MDA levels and increased acetylcholine levels and antioxidant enzyme activities in the exposed mice.
Pelletier A et al. · 2014
Researchers recorded thermal preference and sleep in 18 young male Wistar rats, with nine exposed to a low-intensity RF-EMF at 900 MHz and nine serving as non-exposed controls. During the light period, exposed rats preferred to sleep at an air temperature of 31°C while controls preferred 28°C. During the dark period, no significant differences between groups were found.
Narayanan SN, Kumar RS, Kedage V, Nalini K, Nayak S, Bhat PG · 2014
Researchers studied the effects of 900 MHz radio-frequency electromagnetic radiation on oxidant stress and antioxidant defense in discrete brain regions of adolescent rats. Thirty-six male Wistar rats aged 6 to 8 weeks were divided into a control group, a sham group, and an RF-EMR-exposed group, with 12 animals in each group. The exposed group received 900 MHz RF-EMR at a peak power density of 146.60 µW/cm2 for one hour per day for four weeks from an activated GSM mobile phone. Elevated TBARS levels were found in all brain regions studied, and altered behavioral performances were found in RF-EMR-exposed rats.
Motawi TK, Darwish HA, Moustafa YM, Labib MM. · 2014
Maskey D, Kim MJ · 2014
Researchers applied radiofrequency at a specific absorption rate of 1.6 W/kg or 0 W/kg to mice to study the distribution of BDNF and GDNF in the nuclei of the superior olivary complex. In the exposed group, significant reductions in BDNF immunoreactivity were noted in the lateral superior olive, medial superior olive, superior paraolivary nucleus, and medial nucleus of the trapezoid body. GDNF immunoreactivity was also significantly decreased (p < 0.001) in all superior olivary complex nuclei of the exposed group. The researchers suggested that the decrease in these neurotrophic factors in the superior olivary complex suggests a detrimental effect of RF exposure in the auditory nuclei.
Li H et al. · 2014
Researchers exposed Wistar rats to 2.856 GHz microwaves at power densities of 5, 10, 20, or 30 mW/cm2 for 6 minutes three times a week for up to 6 weeks. Spatial learning and memory, hippocampus structure, brain electrical activity, and neurotransmitter levels were assessed at different time points after the last exposure. The study found dose-dependent memory deficits alongside inhibition of brain electrical activity, hippocampus neuron degeneration, and neurotransmitter disturbances. The researchers suggested that the serotonin system may be involved in the cognitive deficits seen after long-term microwave exposure.
Hu S et al. · 2014
Researchers exposed male Wistar rats to high-power microwave at 30 mW cm−2 for 15 minutes, then administered the dietary supplement KFL orally once daily for 14 days. KFL reversed high-power microwave-induced memory loss and histopathological changes in the hippocampus of rats. KFL also displayed a protective effect against high-power microwave-induced oxidative stress and activated the Nrf2 signaling pathway and its target genes in the hippocampus.
Chen C et al. · 2014
Researchers exposed embryonic neural stem cells (eNSCs) to 1800 MHz radiofrequency electromagnetic fields at SAR values of 1, 2, and 4 W/kg for 1, 2, and 3 days. RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle, or the ratio of differentiated neurons and astrocytes. However, neurite outgrowth of eNSC-derived neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. The mRNA and protein expression of proneural genes Ngn1 and NeuroD were decreased after RF-EMF exposure, while expression of their inhibitor Hes1 was upregulated.
Cetin H et al. · 2014
Researchers divided thirty-two rats and their offspring into three groups: a control group, a 900 MHz group, and an 1800 MHz group, with the two exposed groups receiving electromagnetic radiation for 60 minutes per day during pregnancy and neonatal development. Brain and liver glutathione peroxidase activities, as well as liver vitamin A and beta-carotene concentrations, decreased in the exposed groups. Brain iron, vitamin A, and beta-carotene concentrations increased in the exposed groups, and by the sixth week, selenium concentrations in the brain decreased in the exposed groups. There were no statistically significant differences in glutathione, vitamin E, chromium, copper, magnesium, manganese, and zinc concentrations between the three groups.
Akbari A, Jelodar G, Nazifi S · 2014
Researchers exposed adult male Sprague-Dawley rats to radiofrequency waves generated by a base transceiver station antenna model and measured oxidative stress markers in the cerebellum and encephalon. Antioxidant enzymes measured included glutathione peroxidase, superoxide dismutase, and catalase, along with malondialdehyde (MDA). Exposure to radiofrequency waves decreased antioxidant enzyme activity and increased MDA compared with the control groups. Vitamin C supplementation improved antioxidant enzyme activity and reduced MDA in the group that also received radiofrequency wave exposure.
Unknown authors · 2013
Fifteen Alzheimer's patients were randomly assigned to receive 1-hour daily rTMS combined with cognitive training or sham treatment five sessions per week for six weeks followed by biweekly sessions for three months. The primary outcome was improvement in cognitive score. After six weeks the treatment group improved 3.76 points on ADAS-cog versus 0.47 in placebo (P=0.04), and after 4.5 months improved 3.52 points versus a worsening of 0.38 (P=0.05). Clinical Global Impression of Change scores improved in the treatment group compared to mild worsening in placebo at both time points (P=0.05 each). Neuropsychiatric Inventory scores improved non-significantly.
Redmayne M · 2013
The cross-sectional study recruited 373 Year 7 and 8 students with a mean age of 12.3 years from the Wellington region of New Zealand. Participants completed a questionnaire and measured their normal body-to-phone texting distances. Both cellphones and cordless phones were used by approximately 90% of students. A third of participants had already used a cordless phone for ≥ 7 years. High cellphone use was related to cellphone location at night, being woken regularly, and being tired at school.
Azanza MJ et al. · 2013
Trunk A et al. · 2013
Researchers conducted two double-blind experiments to test effects of a 30-minute 3G UMTS mobile phone-like EMF exposure on human brain electrical activity. In the first experiment with 17 participants, spontaneous EEG spectral power was analyzed in delta, theta, alpha, and beta bands before and after exposure while subjects watched a silent documentary. In the second experiment with 26 participants, auditory event-related potentials and mismatch negativity were measured using a passive oddball paradigm with standard and deviant tones. No measurable effects were found on EEG spectral power in any frequency band. No significant effects were found on the amplitude and latency of ERP components including P50, N100, P200, MMN, and P3a.
Loughran SP et al. · 2013
Researchers used a double-blind, randomized, crossover design with 22 adolescents aged 11–13 years. Participants underwent three sessions with mobile phone-like RF EMF signals at two intensities and a sham session. No clear significant effects of RF EMF exposure were found on waking EEG or cognitive performance.
Kim HS et al. · 2013
Male Sprague-Dawley rats were divided into cage-control, sham-exposed, and RFID-exposed groups and exposed to 915 MHz RFID for 8 h daily, 5 days per week, for 2 or 16 weeks. The whole-body average specific absorption rate was 4 W/kg. FDG-PET images were obtained the day after RFID exposure using micro-PET with a FDG tracer, and the relative cerebral glucose metabolic rate was unchanged in the frontal, temporal and parietal cortexes of exposed rats compared with cage-control and sham-exposed groups.
Guxens M et al. · 2013
Researchers assessed the association between maternal cell phone and cordless phone use during pregnancy and teacher-reported and maternal-reported child behaviour problems at age 5. A total of 2618 children were included in the study. Prenatal cell phone use showed an increased but non-significant association with teacher-reported overall behaviour problems, without a dose-response relationship. Cordless phone use showed odds ratios below 1 or close to unity for teacher-reported overall behaviour problems. Associations with maternal-reported overall behaviour problems and specific behaviour problem subscales were non-significant.
Aït-Aïssa S et al. · 2013
Researchers investigated bioeffects of WiFi signals on developing nervous systems of young rodents by assessing expression levels of 3-Nitrotyrosine, Hsp25, and Hsp70. Daily 2-hour exposures were performed blind in a reverberation chamber at whole-body specific absorption rates of 0, 0.08, 0.4, and 4 W/kg. No significant difference was observed among exposed and sham-exposed groups. The results suggest repeated WiFi exposure during gestation and early life has no deleterious effects on young rat brains.
Sudan M, Kheifets LI, Arah OA, Divan HA, Olsen J. · 2013
The study demonstrated complexities of performing a sibling analysis with a re-examination of associations between cell phone exposures and behavioral problems in the Danish National Birth Cohort. The association of behavioral problems with prenatal and postnatal exposure differed between siblings (OR: 1.07; 95% CI: 0.69-1.66) and non-siblings (OR: 1.54; 95% CI: 1.36-1.74). Within siblings, the association was strongest for first-born children (OR: 1.72; 95% CI: 0.86-3.42) and negative for later-born children (OR: 0.63; 95% CI: 0.31-1.25). The study included 52,680 children, including 5,441 siblings, followed up to age 7. Researchers estimated associations between cell phone exposures and behavioral problems while accounting for the random family effect among siblings.
Hardell L, Carlberg M, Söderqvist F, Mild KH. · 2013
Researchers conducted a case-control study of brain tumour cases aged 18-75 diagnosed from 2007 to 2009, with one population-based control matched on gender and age per case. Among malignant brain tumour cases, 87% participated, and 85% of controls answered the questionnaire. Analogue mobile phone use had an odds ratio of 1.8, which increased to 3.3 with more than 25 years of latency. Digital 2G mobile phone use showed an odds ratio of 1.6, rising to 2.1 with latency over 15-20 years. Cordless phone use had an odds ratio of 1.7, increasing to 2.1 with 15-20 years latency.
de Vocht F, Hannam K, Buchan I. · 2013
Researchers used open-access databases to explore links between potential risk factors and brain and nervous system cancers at an ecological level across 165 countries. National age-adjusted cancer incidence rates from GLOBOCAN 2008 were combined with United Nations Development Report and World Bank data and analyzed using multivariate regression models. 2008 national incidences of brain and nervous system cancers were associated with continent, gross national income in 2008 and Human Development Index Score. The only exogenous risk factor consistently associated with higher incidence was mobile/cellular telecommunications subscription penetration. According to these ecological results the latency period is at least 11-12 years, but probably more than 20 years.
Byun YH et al. · 2013
Researchers conducted a longitudinal study of 2,422 children in 10 Korean cities to examine the association between mobile phone use and ADHD symptoms while considering lead exposure. They found that mobile phone use for voice calls was linked to higher ADHD symptom risk, but only among children with relatively high lead exposure. The results suggest that simultaneous exposure to lead and RF from mobile phone use was associated with increased ADHD symptom risk, though reverse causality could not be excluded.
Benson VS et al. · 2013
Researchers examined the relation between mobile phone use and incidence of intracranial CNS tumours and other cancers in 791,710 middle-aged women in the UK Million Women Study. During 7 years' follow-up, 51,680 incident invasive cancers and 1,261 incident intracranial CNS tumours occurred. Risk among ever versus never users was not increased for all intracranial CNS tumours (RR = 1.01, 95% CI = 0.90-1.14, P = 0.82) nor for cancer at 18 other specified sites. For long-term users compared with never users, there was no appreciable association for glioma (10+ years: RR = 0.78, 95% CI = 0.55-1.10, P = 0.16) or meningioma (10+ years: RR = 1.10, 95% CI = 0.66-1.84, P = 0.71).
Behari J, Nirala JP. · 2013
A SAR measurement system was developed for a brain phantom in a Perspex box. The phantom box volume matched a small rat and was illuminated by a 3G mobile phone at 1718.5 MHz. A moving platform changed the phone's angular position at 2 degrees per minute up to 20 degrees while induced fields were measured. SAR values computed from induced fields were higher than those from induced field measurements alone and varied with angular position, but remained well below human safety criteria. SAR was also measured by temperature rise and compared with the induced-field results, and measurements were repeated in a 10 g phantom in a cubical box for safety criteria comparison.
Maaroufi K et al. · 2013
Researchers exposed Long-Evans rats to 900 MHz EMF alone or combined with iron overload and tested them in spatial learning tasks including the Morris water maze, radial-arm maze, and object exploration. EMF-exposed rats were impaired in the object exploration task but not in the navigation or working memory tasks. Combined EMF and iron overload did not produce greater behavioral or neurochemical deficits than EMF alone, and neither treatment caused global oxidative stress.
