Aydin D et al. · 2011
Researchers performed simulations using real data from the CEFALO case–control study to assess how recall errors and selection bias affect odds ratios for mobile phone use and brain tumor risk in children and adolescents. In a validation study, cases overestimated their number of calls by 9% on average and controls by 34%, while cases overestimated call duration by 52% and controls by 163%. Participation rates were 83% for cases and 71% for controls, and the combined impact of recall error and selection bias on estimated odds ratios was complex across various scenarios.
Chaturvedi CM et al. · 2011
Maaroufi K et al. · 2011
Researchers examined the relationship between iron status, EMF exposure, and brain oxidative stress in young adult rats. They exposed rats to iron overload, 150 kHz EMF, or both, and measured lipid peroxidation and antioxidant enzyme activity in the prefrontal cortex, hippocampus, striatum, and cerebellum. Iron overload alone stimulated antioxidant defenses in the cerebellum and prefrontal cortex but did not cause oxidative stress. EMF exposure alone increased lipid peroxidation mainly in the cerebellum without affecting antioxidant defenses. Combined exposure further increased lipid peroxidation compared to EMF alone and abolished the antioxidant defense increase from iron overload alone.
Kaprana AE et al. · 2011
Thirty healthy rabbits were exposed to GSM-900 radiation for 60 minutes while auditory brainstem responses were recorded at regular intervals. The mean absolute latency of waves III–V showed a statistically significant delay after 60, 45, and 15 minutes of exposure, respectively. Interwave latencies I–V and III–V were significantly delayed after 30 minutes of radiation. No significant delay was found in the ear contralateral to the radiation source at 60 minutes. ABR measurements returned to baseline 24 hours after exposure.
Prochnow N et al. · 2011
Researchers applied UMTS radio-frequency signals to male Wistar rats at whole-brain SAR levels of 0, 2, and 10 W/kg for 120 minutes. They measured stress hormones corticosterone and ACTH and recorded hippocampal long-term potentiation (LTP) and long-term depression (LTD). Cage exposure increased corticosterone and ACTH levels and was associated with generally decreased LTP and LTD. At 2 W/kg the rats showed no difference from sham in LTP and LTD, while at 10 W/kg a significant reduction in both was observed.
Poulletier de Gannes F et al. · 2011
Researchers exposed three human brain cell lines and primary cortical neurons to the EDGE signal at 1800 MHz. Four exposure conditions were tested: 2 and 10 W/kg for 1 and 24 hours. Reactive oxygen species production was measured by flow cytometry using the DCFH-DA probe. All cells tested responded to rotenone treatment by increasing ROS production. The EDGE signal did not induce oxidative stress under any test condition, including at 10 W/kg.
Amara S et al. · 2011
Researchers studied the effects of co-exposure to a static magnetic field (SMF) and cadmium on antioxidant enzyme activity and DNA integrity in rat brain. Cadmium exposure alone reduced antioxidant enzyme activity, including GPx, CAT, and SOD, in the frontal cortex and hippocampus, and increased markers of oxidative damage. When SMF (128 mT, 1 hour/day for 30 consecutive days) was combined with cadmium, SOD activity and glutathione levels in the frontal cortex fell further compared with the cadmium-only group, and MDA concentration also increased further. SMF exposure did not alter DNA oxidation levels in cadmium-exposed rats.
Chen YB, Li J, Liu JY, Zeng LH, Wan Y, Li YR, Ren D, Guo GZ. · 2011
Researchers exposed male BALB/c mice to electromagnetic pulses at a peak intensity of 400 kV/m for a total of 200 pulses, then measured associative learning, oxidative stress in the brain, and serum chemistry. Associative learning was reduced significantly at 12 hours and 1 day after exposure compared with sham control, but recovered at 2 days post exposure. Lipid peroxidation and chemiluminescence intensity in brain tissue increased significantly, while activity of antioxidant enzymes decreased significantly, at 3 h, 6 h, 12 h and 1 d post EMP exposure, with all parameters recovering at 2 days. Pretreatment with TMG showed protective effects against EMP exposure.
Ghodbane S et al. · 2011
Researchers exposed male adult rats to a static magnetic field (128 mT, 1 hour per day for 5 days) and examined antioxidant enzymes and selenium levels in liver, kidney, muscle, and brain. Static magnetic field exposure decreased selenium levels in kidney, muscle, and brain, and decreased GPx activity in kidney and muscle. In the liver, static magnetic field exposure increased total GSH levels and total SOD activities, while glutathione reductase activity was unaffected. Selenium supplementation restored selenium levels and GPx activity in kidney and muscle, but did not bring down the elevated GSH and SOD levels in liver.
van Nierop LE et al. · 2011
Researchers tested whether movement-induced time-varying magnetic fields within the static magnetic stray field of a 7 Tesla MRI scanner affected neurocognition. Using a double-blind randomised crossover design, 31 healthy volunteers were tested in a sham (0 T), low (0.5 T) and high (1.0 T) exposure condition, with standardised head movements made before every neurocognitive task to induce time-varying magnetic fields. Of six tested neurocognitive domains, attention and concentration were negatively affected, and visuospatial orientation was also affected after exposure.
Shin EJ, Nguyen XK, Nguyen TT, Pham DT, Kim HC. · 2011
Researchers examined whether repeated extremely low frequency magnetic field exposure induces fos-related antigen immunoreactivity in the striatum and nucleus accumbens of mice. Exposure at 0.3 or 2.4 mT for 1 hour per day over fourteen consecutive days significantly induced hyperlocomotor activity and fos-related antigen immunoreactivity in a field intensity-dependent manner. The fos-related antigen immunoreactivity lasted for at least 1 year, while locomotor activity returned near control level 3 months after the final exposure.
Lahijani MS, Bigdeli MR, Kalantary S. · 2011
Researchers investigated the effects of sinusoidal electromagnetic fields on the brain histopathology and structures of preincubated white leghorn chicken embryos. Three hundred fertilized eggs were divided into experimental, control, and sham groups, with the experimental eggs exposed to three different field intensities of 1.33, 2.66, and 7.32 mT for 24 hours before incubation. The results suggested that the electromagnetic fields induce brain damages at different levels.
Frilot C 2nd, Carrubba S, Marino AA. · 2011
Researchers exposed rats to a 2.5-G, 60-Hz magnetic field and used positron emission tomography with fluorodeoxyglucose to identify brain regions where glucose uptake changed. Increased glucose utilization occurred in hindbrain voxels when the field was applied orthogonally to the sagittal plane, but not when the angle between the field and the sagittal plane varied randomly. Distinct activation effects were observed in response to transient and steady-state magnetic stimuli.
Corbacio M et al. · 2011
Ciejka E, Kleniewska P, Skibska B, Goraca A. · 2011
The study aimed to assess the effect of extremely low frequency magnetic field parameters on reactive oxygen species generation in brain tissue of experimental animals depending on the time of exposure. Exposure at 30 min/day for 10 days caused a significant increase in lipid peroxidation and an insignificant increase in hydrogen peroxide and free sulphydryl groups. Exposure at 60 min/day caused a significant increase in free sulphydryl groups and protein concentration, which the researchers described as indicating an adaptive mechanism.
Chu LY et al. · 2011
Researchers investigated whether extremely low frequency magnetic field (ELF-MF) induces lipid peroxidation and reactive oxygen species in mouse cerebellum. After exposure to 60 Hz ELF-MF at 2.3 mT intensity for 3 hours, malondialdehyde and hydroxyl radical levels increased significantly. The researchers concluded that ELF-MF may induce oxidative stress in mouse cerebellum, though the mechanism remains to be characterized.
Volkow ND et al. · 2011
Researchers used positron emission tomography to measure brain glucose metabolism in 47 healthy participants, once with the right cell phone activated for 50 minutes and once with both cell phones deactivated. Whole-brain metabolism did not differ between the on and off conditions, but metabolism in the region closest to the antenna was significantly higher in the on condition than the off condition. The researchers noted that this finding is of unknown clinical significance.
Sirav B, Seyhan N · 2011
Researchers exposed male and female Wistar albino rats to 0.9 and 1.8 GHz continuous-wave radiofrequency radiation for 20 minutes to investigate effects on blood-brain barrier permeability. A significant increase in albumin was found in the brains of the RF-exposed male rats when compared to sham-exposed male brains. In female rats, no albumin extravasation was found in the brain after RFR exposure. The researchers noted that these results suggest that exposure at levels below the international limits can affect vascular permeability in the brain of male rats.
Papageorgiou CC et al. · 2011
Fifteen male and fifteen female subjects, matched for age and education level, were investigated while performing a modified version of the Hayling Sentence Completion test adjusted to induce working memory. ERPs were recorded at 30 scalp electrodes, both without and with exposure to a Wi-Fi signal. Male subjects showed decreased P300 amplitudes compared to female subjects, but only in the presence of Wi-Fi EMF. The researchers concluded that Wi-Fi exposure may exert gender-related alterations on neural activity associated with attentional resources during a linguistic working-memory test.
Noor NA, Mohammed HS, Ahmed NA, Radwan NM · 2011
Masuda H et al. · 2011
The study aimed to detect reproducible responses to local radiofrequency exposure in the parietal cortex of anesthetized rats and to determine their dependence on exposure intensity. The target cortex tissue was locally exposed to 2-GHz RF using a figure-eight loop antenna at averaged specific absorption rates of 10.5, 40.3, 130, and 263 W/kg. All measured parameters except calf hypodermis temperature increased significantly in exposed animals compared with sham-exposed ones during 18-min exposures. The local cerebral blood flow elevation seemed to be driven by the rise in target temperature, but not by rectal temperature, in the early part of RF exposure or at low-intensity RF exposure.
Lowden A et al. · 2011
Researchers investigated the effects of a double-blind radiofrequency exposure on sleepiness and EEG measures during sleep. Forty-eight subjects with a mean age of 28 years underwent three hours of controlled exposure prior to sleep, followed by a full-night polysomnographic recording in a sleep laboratory. Following exposure, slow-wave sleep decreased by 9.5 minutes and the latency to Stage 3 sleep was prolonged by 4.8 minutes compared to sham. No differences were found between subjects who had previously reported mobile phone-related symptoms and those who had not.
Liu ML, Wen JQ, Fan YB. · 2011
Researchers investigated whether green tea polyphenols could protect cultured rat cortical neurons from injury caused by 1800 MHz electromagnetic field exposure from a mobile phone. Mobile phone irradiation for 24 hours induced marked neuronal cell death, as measured by MTT and TUNEL assays. Green tea polyphenols significantly inhibited the radiation-induced increases in active Bax, while total Bax levels showed no marked changes.
Leung S et al. · 2011
This study examined sensory and cognitive processing in adolescents, young adults and older adults when exposed to 2G and 3G mobile phone signals. Forty-one 13–15 year olds, forty-two 19–40 year olds and twenty 55–70 year olds were tested using a double-blind cross-over design, where each participant received Sham, 2G and 3G exposures, separated by at least 4 days. On a memory task, adolescents performed less accurately during 3G exposure compared to Sham, and delayed brainwave responses were found in both 2G and 3G conditions across all age groups.
Kwon MS et al. · 2011
Researchers used positron emission tomography with an 18F-deoxyglucose tracer to investigate the effects of mobile phone radiation on cerebral glucose metabolism in humans. Thirteen young right-handed male subjects were exposed to a pulse-modulated 902.4 MHz Global System for Mobile Communications signal for 33 minutes while performing a simple visual vigilance task. The relative cerebral metabolic rate of glucose was significantly reduced in the temporoparietal junction and anterior temporal lobe of the right hemisphere, on the same side as the exposure. The exposure did not affect task performance, measured by reaction time and error rate.
