Unknown authors · 2006
Researchers exposed female mice to 50 Hz, 1.2 mT electromagnetic fields for 8 hours per day throughout pregnancy. Exposed dams gained weight more slowly (29.0% vs 47.8%) and had a lower producing rate (60% of controls), with miscarriages, fetal loss, and malformed fetuses observed. The average number of offspring per mouse decreased (11 ± 1.6 vs 7 ± 2.0), and prenatally exposed offspring showed slower weight gain in the first two weeks and delayed eye opening and tooth eruption.
Nagaoka T et al. · 2006
Researchers had previously developed a whole-body numerical female model of an adult Japanese non-pregnant average figure. A new fetus model including inherent tissues of pregnant women was constructed based on abdominal MRI data of a 7-month pregnant woman. A whole-body pregnant woman model was developed by combining the new fetus and the female models. The anatomical details of the developed pregnant woman model and basic SAR characteristics for whole-body exposure to RF electromagnetic fields are demonstrated.
Finnie JW, Cai Z, Blumbergs PC, Manavis J, Kuchel TR. · 2006
Researchers exposed pregnant mice to 900 MHz fields at 4 W/kg for 60 minutes daily from gestation day 1 to 19. Control mice were sham-exposed or freely mobile without restraint. Fetal brains were examined for c-fos expression in multiple regions using immunohistochemistry. No difference in c-fos immunoreactivity was found between exposed and control fetal brains.
Finnie JW, Blumbergs PC, Cai Z, Manavis J, Kuchel TR. · 2006
Pregnant mice were exposed to 900 MHz radiofrequency fields at 4 W/kg for 60 minutes daily from gestational day 1 to day 19. Fetal brains were examined for albumin extravasation in multiple regions including cerebral cortex, thalamus, basal ganglia, hippocampus, cerebellum, midbrain and medulla. No albumin extravasation was found in exposed or control brains, indicating no increase in vascular permeability.
Ferreira AR et al. · 2006
Researchers used the micronucleus assay to assess chromosomal damage in erythrocytes from rat offspring exposed to non-thermal UHF-EMF from a cellular phone during embryogenesis. The irradiated group showed a significant increase in micronuclei occurrence. No significant differences were found in any oxidative parameter of offspring blood and liver. The average number of pups in each litter was not significantly altered.
Celik O, Hascalik S. · 2004
The study was planned to determine the effects of electromagnetic fields from cellular phones on baseline fetal heart rate, acceleration, and deceleration. Forty pregnant women undergoing non-stress testing were enrolled. Non-stress tests were recorded while subjects held a cellular phone in standby mode and dialing mode for five minutes each, and also with no phone present for ten minutes.
Panagopoulos DJ, Karabarbounis A, Margaritis LH · 2004
The study used GSM mobile phones with a carrier frequency at 900 MHz. Insects were exposed to the near field of the mobile phone antenna for 6 minutes per day during the first 2–5 days of adult life. Modulated radiation decreased reproductive capacity by 50–60% while nonmodulated radiation decreased it by 15–20%. The authors suggested the radiation decreases the rate of cellular processes during gonad development.
Pyrpasopoulou A et al. · 2004
Researchers exposed pregnant rats to pulsed GSM-like radiofrequency radiation at 9.4 GHz and 5 microW/cm2 during early gestation. They measured bone morphogenetic protein and receptor expression in newborn kidneys using semi-quantitative duplex RT-PCR. Exposure increased BMP-4 and BMPR-IA expression and decreased BMPR-II expression, with statistical significance depending on exposure timing. Immunohistochemistry and in situ hybridization revealed aberrant expression and localization of these molecules. The authors suggest these molecular changes do not affect renal organogenesis but may reflect a developmental delay, and that exposure timing influences effects.
Grigor'ev IuG. · 2003
The study aimed to investigate biological effects of mobile phone electromagnetic field on chick embryo using mortality rate as a risk assessment. Chicken embryos were exposed to EMF from a GSM mobile phone during the 21-day embryonic development. The embryo mortality rate in the incubation period increased to 75% versus 16% in the control group.
Weisbrot D, Lin H, Ye L, Blank M, Goodman R. · 2003
Researchers exposed fruit flies to a discontinuous RF signal from a GSM multiband phone at 900/1,900 MHz with SAR approximately 1.4 W/kg for 10 days from egg laying through pupation. The non-thermal radiation increased offspring numbers, elevated hsp70 levels, increased SRE DNA-binding, and induced ELK-1 phosphorylation.
Unknown authors · 2001
The study examined the effect of a sinusoidal 50 Hz magnetic field on preimplantation CBA/S mouse embryos in vitro. Embryos were exposed to a field of 10 A/m rms corresponding to 13 microT rms while cultured at 37°C in a CO2 incubator. Vitality and developmental stages were similar between groups, though slightly more dead embryos appeared on day 1 in the exposed group (P<0.05) and development was slightly impaired. The authors concluded that the exposure did not significantly disturb development up to the blastocyst stage.
Nelson BK, Snyder DL, Shaw PB · 2001
Researchers gave pregnant rats methanol at 0, 2, or 3 g/kg on gestation day 9 or 13, combined with RF radiation on day 9 or 2ME on day 13. On day 9, RF radiation or methanol increased fetal resorptions without interaction, and resorptions were highest when treatments were separated by 1.5 hours. The higher methanol dose also reduced fetal weights. On day 13, 2ME or methanol increased malformations with a positive interaction between them, while fetal weights were reduced by each agent alone without interaction.
Cheever KL et al. · 2001
Researchers exposed pregnant rats to 10 MHz radiofrequency radiation and measured metabolism and distribution of 2-methoxyethanol and its metabolite methoxyacetic acid. Radiofrequency exposure reduced total body clearance of radiolabeled 2-methoxyethanol but did not change methoxyacetic acid levels in serum, embryos, or extraembryonic fluid. Protein adduct formation in embryos did not differ in a way that would explain the reported synergy between radiofrequency radiation and 2-methoxyethanol.
Bastide M, Youbibier-Simoa BJ, Lebecq JC, Giaimis J. · 2001
Researchers investigated continuous exposure of chick embryos and young chickens to EMFs from video display units and GSM cell phone radiation, including radiation attenuated by copper gauze. Permanent exposure to VDU EMFs was associated with significantly increased fetal loss (47-68%) and markedly depressed levels of circulating specific antibodies (lgG), corticosterone and melatonin. Under chronic exposure, GSM cell phone radiation was harmful to chick embryos, stressful for healthy mice, and synergistic with cancer by depleting stress hormones in mice. The same pathological results occurred after substantial reduction of microwaves by copper gauze attenuation.
Unknown authors · 2000
Researchers cultured mouse pre-antral follicles for 5 days and exposed them to pulsed ELF-EMF at 33 Hz or 50 Hz. ELF-EMF did not affect follicular growth over 3 days, but on day 5 the 33 Hz exposure significantly reduced growth compared to controls, while 50 Hz did not. ELF-EMF severely impaired antrum formation at both frequencies, with control follicles forming antral cavities at 79% versus 30% at 33 Hz and 51.6% at 50 Hz. Oocytes from exposed follicles showed a reduced ability to resume meiotic maturation compared to controls.
Bornhausen M, Scheingraber H · 2000
Mezhevikina LM, Khramov RN, Lepikhov KA · 2000
Researchers cultured two-cell mouse embryos in vitro and exposed them to electromagnetic irradiation in the millimeter range. After 30 min of exposure, the embryos acquired the ability to develop on their own and could reach the stage of blastocyst in 150 microliters of Whitten cultural medium without serum or growth factors. The authors proposed that millimeter range electromagnetic waves activate metabolic processes and specifically the synthesis of factors controlling early embryonic development in culture.
Dasdag S; Akdag MZ; Ayy ld z O et al. · 2000
Researchers studied the effects of microwaves emitted by cellular phones on peripheral blood parameters and birth weights of rats. The birth weight of offspring in the experimental group was significantly lower than in the sham-exposed group (p < 0.001). No blood parameters differed following exposure, and rectal temperatures showed no significant differences between groups. All parameters investigated were normal in the next generation of rats.
Cobb BL et al. · 2000
Researchers exposed pregnant rats to UWB electromagnetic fields during gestation days 3-18, with some pups also exposed for 10 days after birth, then evaluated offspring for behavioral, functional, and morphological effects. UWB-exposed pups emitted significantly more stress vocalizations than sham-exposed pups, and the medial-to-lateral length of the hippocampus was significantly longer in UWB-exposed pups than in sham-exposed animals. Researchers noted there does not appear to be a unifying physiological or behavioral relationship among the significant differences observed.
Nelson BK, Snyder DL, Shaw PB · 1999
The purpose was to determine if synergistic effects of radiofrequency radiation and 2-methoxyethanol generalize to other chemicals. Rats received salicylic acid at 0, 250, or 350 mg/kg by gavage on gestation day 9 or 13. Rats given salicylic acid on day 9 were exposed to radiofrequency radiation sufficient to maintain colonic temperature at 41 degrees C for 60 minutes or received a sham exposure, while those given salicylic acid on day 13 also received 0 or 100 mg/kg 2-methoxyethanol by gavage. Fetuses were examined for external malformations on gestation day 20.
Galat VV et al. · 1999
Researchers investigated the effects of nonthermal millimeter-range electromagnetic radiation on early development of mouse and sea urchin embryos. An MRTA-01E-03 generator with a frequency of 54-78 GHz and radiation intensity of 0.06 mWt/cm2 was used, and embryos were irradiated for 30 minutes at the two-blastomere stage. More mouse embryos reached the blastocyst stage (97.3%) compared with controls (87.5%), and the total cultivation time to reach that stage was shorter (72 h) than in controls (96 h). For sea urchin embryos, the radiation had an effect only when embryos with weakened viability were tested.
Nelson BK, Conover DL, Krieg EF Jr, Snyder DL, Edwards RM · 1998
Researchers tested whether environmental temperature changes the interactive developmental toxicity of radiofrequency radiation and 2-methoxyethanol. Environmental temperature affected the specific absorption rate needed to maintain a given colonic temperature but did not affect the interactive developmental toxicity. The results add to evidence that developmental toxicity of radiofrequency radiation is associated with colonic temperature, not with specific absorption rate. Fetuses were examined for external malformations on gestation day 20.
Klug S, Hetscher M, Giles S, Kohlsmann S, Kramer K, · 1997
Researchers exposed 9.5-day-old rat embryos for up to 36 hours to radiofrequency electric and magnetic fields with modulation frequencies of 16, 60, and 120 Hz. The exposure included electric field strengths of 60 and 600 V/m, magnetic inductions of 0.2 and 2.0 microtesla, and specific absorption rates of 0.2, 1.0, and 5.0 W/kg. Neither the electric nor the magnetic fields interfered significantly with normal embryo growth and differentiation when assessed on day 11.5 using a scoring system, photographs, histology, and protein content.
Indulski JA, Makowiec-Dabrowska T, Zmyslony M, Siedlecka J · 1997
The authors reviewed epidemiological data on the relationship between reproductive disorders and electromagnetic field exposure from power lines, industrial devices, medical appliances, video display terminals, and household devices. The analyzed studies examined effects on female and male reproduction, including spontaneous abortion, stillbirth, premature birth, low birth weight, congenital malformations, and progeny gender proportion among occupationally exposed persons.
Nelson BK, Conover DL, Shaw PB, Snyder DL, Edwards RM · 1997
Researchers exposed pregnant rats to radiofrequency radiation that raised colonic temperature to 42.0°C for 10 minutes while administering various doses of 2-methoxyethanol on gestation day 13. Dose-related developmental toxicity from 2-methoxyethanol occurred both with and without the radiation exposure. However, the radiation changed the shape of the dose-effect curve for 2-methoxyethanol.
